A global dataset for prevalence of Salmonella Gallinarum between 1945 and 2021

Abstract

Pullorum disease and fowl typhoid are among the most significant poultry diseases worldwide. However, the global burden of these diseases remains unknown. Most importantly, the parameters contributing to the prevalence of Salmonella Gallinarum variants are not well documented. Therefore, in this study, we present a systematic review and meta-analysis of the global prevalence of Salmonella Gallinarum during 1945–2021. In total, 201 studies were identified for qualitative analysis (>900 million samples). The meta-analysis was subjected to over 183 screened studies. The global prevalence of S. Gallinarum (percentage of positive samples in total samples) was 8.54% (95% CI: 8.43–8.65) and showed a V-shaped recovery over time. Pullorum disease is most common in Asia, particularly in eastern China. Further investigations on chicken origin samples revealed significant differences in S. Gallinarum prevalence by gender, breed, raising mode, economic use, and growth stage, indicating a critical role of vertical transmission. Together, this study offered an updated, evidence-based dataset and knowledge regarding S. Gallinarum epidemics, which might significantly impact decision-making policy with targeted interventions.

Comprehensive Assessment of Subtyping Methods for Improved Surveillance of Foodborne Salmonella

“…Our results showed a high level of contamination along the poultry production chain, especially in the market, which could be a potential risk for consumers. No isolate was found in the samples collected from breeding farms, possibly because positive samples were few, and most of the contaminations were caused by Salmonella Gallinarum biovar Pullorum, which are highly avian-adapted and grew too slow to be isolated in selective enrichment medium used during the sampling periods ( 22 ). Due to dominance of S .…”

Characterization of Two-Component System CitB Family in Salmonella Pullorum

“…S. Pullorum, causing Pullorum disease in poultry, is an important pathogen in great need of control and disease eradication [ 3 , 5 , 9 ]. Nevertheless, the mechanism of how S. Pullorum targets and continuously colonizes the host’s organs remains obscure.…”

“…Our previous meta-analysis showed that S . Pullorum is still very common in many regions, especially in developing countries [ 9 ], although it has been the target of disease eradication schemes in most industrialized countries [ 2 , 10 , 11 , 12 ].…”

Chemistry and bioactivity of lindenane sesquiterpenoids and their oligomers

“…38,39 Thus, the diverse LSs also show various and signicant biological activities, such as anti-inammation, [40][41][42][43] antitumor, [44][45][46] and anti-infection. [47][48][49][50] In particular, 13 ′ -Omethyl succinylshizukaol C has been reported to show about 1000-fold stronger antimalarial activity than that of artemisinin. 48,50 Considering their diverse skeletons and strong bioactivities, [5][6][7][8][9][10]44,45,[47][48][49][50] the total synthesis of LSs and their oligomers has also attracted signicant interest from organic chemists, and thus far, complex and bioactive oligomers with seven types of skeletons have been synthesized by several groups.…”