A geometric model for the myocardium: Biventricular wall stresses in normal and hypertrophied states

Mirsky, Israel; Laks, MM

doi:10.1007/bf02461060

Cited by 6 publications

(1 citation statement)

References 34 publications

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“…Collagens are the main fibrous component of the cardiac ECMs (Bashey et al., 1992 ; Nikolov & Popovski, 2022 ). In patients with heart failure, collagen accumulation is associated with the severity of ventricular diastolic dysfunction (Mirsky & Pasipoularides, 1980 ; Peterson et al., 1978 ). In particular, myocardial fibrosis, characterized by the excess deposition of ECMs, including abnormal collagen architectures, is observed in varying degrees in patients with HFpEF and is associated with a worse prognosis, as supported by a study using late gadolinium‐enhanced magnetic resonance imaging and autopsy (Shah et al., 2020 ).…”

Section: Elastic Components Of the Ventricular Myocardiummentioning

confidence: 99%

Comparative analysis of ventricular stiffness across species

Usui,

Hanashima,

Hashimoto

et al. 2024

Physiological Reports

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Investigating ventricular diastolic properties is crucial for understanding the physiological cardiac functions in organisms and unraveling the pathological mechanisms of cardiovascular disorders. Ventricular stiffness, a fundamental parameter that defines ventricular diastolic functions in chordates, is typically analyzed using the end‐diastolic pressure–volume relationship (EDPVR). However, comparing ventricular stiffness accurately across chambers of varying maximum volume capacities has been a long‐standing challenge. As one of the solutions to this problem, we propose calculating a relative ventricular stiffness index by applying an exponential approximation formula to the EDPVR plot data of the relationship between ventricular pressure and values of normalized ventricular volume by the ventricular weight. This article reviews the potential, utility, and limitations of using normalized EDPVR analysis in recent studies. Herein, we measured and ranked ventricular stiffness in differently sized and shaped chambers using ex vivo ventricular pressure‐volume analysis data from four animals: Wistar rats, red‐eared slider turtles, masu salmon, and cherry salmon. Furthermore, we have discussed the mechanical effects of intracellular and extracellular viscoelastic components, Titin (Connectin) filaments, collagens, physiological sarcomere length, and other factors that govern ventricular stiffness. Our review provides insights into the comparison of ventricular stiffness in different‐sized ventricles between heterologous and homologous species, including non‐model organisms.

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