Myocardial Dysfunction in Experimental Septic Shock

Krösl, P.; Pretorius, Jannie

doi:10.1007/978-3-642-76736-4_56

Cited by 1 publication

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“…Unfortunately, all of these parameters are significantly altered in sepsis. Circulating blood volume and preload decrease as a result of "capillary leak", afterload is profoundly altered by pronounced vasodilatation induced in part by nitric oxide (Thiemermann 1997 (Krosl and Pretorius, 1993). One of the first groups to investigate this problem demonstrated increased contractility following the induction of sepsis in the dog and related cardiac failure to circulatory deficits (for review see Raymond, 1990).…”

Section: Does the Heart Fail In Sepsis?mentioning

confidence: 99%

Alterations in intrinsic heart rate in endotoxemia

Wearden¹

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After much early debate, it is now well recognized that the origin of the heart beat is myogenic, or intrinsic, to the heart. It has been felt that the intrinsic heart rate (IHR) is constant and that the observed heart rate is controlled by tonal alterations in the activity of the autonomic nervous system in response to various stimuli. Some investigators have recognized, however, that the intrinsic heart rate (IHR) can be altered in certain conditions. Sepsis, or the host response to bacterial infection, is recognized as a stress to the host that results in decreased myocardial contractility and tachycardia. Some previous work has suggested that this tachycardia may exist outside the tonal regulation of the autonomic nervous system, raising the possibility of an elevation of the IHR. Utilizing an E. coli lipopolysaccharide (LPS) endotoxin model of sepsis in the rat, this work demonstrates an elevation of the IHR in sepsis. The experimental evidence further suggests that the β-adrenoceptor participates in the induction of the elevation in IHR early in the septic process. By sixteen hours after LPS administration the β-adrenoceptor is, however, no longer required for the ongoing elevation of IHR. It is also demonstrated that the elevation in IHR is more prolonged than the contractile dysfunction induced by LPS. iii Dedication To Andrea, Andrew, Mara and Luke Without your support this would not have been possible Without your unconditional love this would all be meaningless

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Section: Does the Heart Fail In Sepsis?mentioning

confidence: 99%

Alterations in intrinsic heart rate in endotoxemia

Wearden¹

View full text Add to dashboard Cite

show abstract

Myocardial Dysfunction in Experimental Septic Shock

Cited by 1 publication

References 47 publications

Alterations in intrinsic heart rate in endotoxemia

Alterations in intrinsic heart rate in endotoxemia

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