A genome-wide association study of immune response traits in Canadian Holstein cattle

Thompson-Crispi, K.A.; Sargolzaei, Mehdi; Ventura, Ricardo Vieira; Abo-Ismail, Mohammed; Miglior, F.; Schenkel, F. S.; Mallard, Bonnie A.

doi:10.1186/1471-2164-15-559

Cited by 68 publications

(57 citation statements)

References 57 publications

(63 reference statements)

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“…Moreover, adaptive immune response traits are heritable, and therefore it is possible to breed for improved immunity response and decreasing the occurrence of disease. In dairy cows with superior antibody-mediated (AMIR) and cellmediated immune responses (CMIR) a lower occurrence of many diseases including mastitis has been demonstrated ( Thompson-Crispi et al 2014). …”

Section: Resultsmentioning

confidence: 99%

Genomic response to natural selection within alpine cattle breeds

Moravčíková¹,

Simčić²,

Mészáros³

et al. 2018

CZECH J ANIM SCI

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Moravčíková N., Simčič M., Mészáros G., Sölkner J., Kukučková V., Vlček M., Trakovická A., Kadlečík O., Kasarda R.. (2018): Genomic response to natural selection within alpine cattle breeds. Czech J. Anim. Sci., 63, 136-143.The aim of this study was to analyse the genomic regions that have been target of natural selection with respect to identifying the loci responsible mainly for fitness traits across six alpine cattle breeds. The genome-wide scan for selection signatures was performed using genotyping data from totally 465 animals. After applying data quality control, overall 35 873 single nucleotide polymorphisms were useable for the subsequent analysis. The detection of genomic regions affected by natural selection was carried out using the approach of principal component analysis. The analysis was based on the assumption that markers extremely related to the population structure are also candidates for local adaptation potential of the population. Based on the expected false discovery rate equal to 10% up to 1138 loci were identified as outliers. The strongest signals of selection were found in genomic regions on BTA 1, 2, 3, 6, 9, 11, 13, and 22. Most genes located in the identified regions have been previously associated with immunity system as well as body growth and muscle formation that mainly reflect the pressure of both natural and artificial selection in respect to adaptation of analysed breeds to the local environmental conditions. The results also signalized that those regions represent a correlated selection response in way to maintain the fitness of analysed breeds.

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Section: Resultsmentioning

confidence: 99%

Genomic response to natural selection within alpine cattle breeds

Moravčíková¹,

Simčić²,

Mészáros³

et al. 2018

CZECH J ANIM SCI

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“…The BoLA-DQ complex plays a relevant role for enhanced immune response in dairy cows. The BoLA-DQ5 and BoLA-DQA5 map in the chromosome 23 (BTA23:25855146-25863045 and BTA23:25404020-25411642, respectively), within the 250,000-bp flank region (Hapmap44002-BTA-110636, 25178791 bp) of a SNP of the ELOVL5 gene, which was found highly associated with antibody-mediated immune response in Holstein cows (Thompson-Crispi et al, 2014). Aukrust et al (1995) working in humans reported the activation of the tumor necrosis factor system subsequent to the reduction of GSH in CD4+ lymphocytes.…”

Section: Pathway Interpretation In Is Cowsmentioning

confidence: 99%

Transcriptome profiles of whole blood in Italian Holstein and Italian Simmental lactating cows diverging for genetic merit for milk protein

Sandri

Stefanon

Loor

2015

Journal of Dairy Science

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The aim of the research was to investigate the variation of gene expression in the blood of lactating cows in relation to the genetic merit for productive traits. For the study, 24 Italian Holstein (IH) cows from a single farm and 24 Italian Simmental (IS) cows from a second farm were selected. Cows were in mid-lactation, and farms had similar management and feeding conditions. For each breed, cows were separated into 3 classes of estimated breeding value (EBV) for milk protein yield (EBVp), namely, 8 cows with low EBVp (low group, LG), 8 cows with high EBV (high group, HG), and the 8 cows closest to the median (medium group, MG). Gene expression was measured on blood with a whole-transcriptome bovine microarray, and data of LG and HG were expressed relative to MG. The number of differentially expressed genes between the low and high EBVp groups were 443 for IS and 281 for IH cows. The IS cows had a greater number of genes (398 vs. 241 in IH cows) with opposite expression in the high and low EBV groups, compared with the MG. In IS cows, the largest number of pathways affected were within the KEGG subcategories of "energy metabolism," "lipid metabolism," and "metabolism of cofactors and vitamins." Furthermore, the "glutathione metabolism" pathway was markedly affected, with GSTM1 (from glutathione-S-transferase family), GSS (glutathione synthetase), and G6PD (glucose-6-phosphate dehydrogenase) upregulated in the IS HG but downregulated in the IS LG group. The "intestinal immune network for IgA production" pathway had 2 bovine leukocytes antigen (BoLA-DQ) genes, and the B-cell activating factor of the TNF superfamily (TNFSF13B) upregulated in the IS LG group and downregulated in the IS HG group. The IH cows had the highest number of affected pathways in the "metabolism" and "organismal systems" categories, the latter with 5 out of 10 subcategories relative to the immune system. Within the "T cell receptor signaling pathway," the IH HG cows had upregulation of the CD1d, CD4, and CD3 antigens and downregulation of the NFkB subunit ReLa gene. This study revealed that specific metabolic and immunological pathways are directly related to genetic merit, and could be considered a signature of quantitative selection. Starting from these preliminary observations, the comparison of differentially expressed genes among animals with different EBVp seems a promising approach to unravel molecular response at a blood level associated with productive traits.

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“…Como parte do sistema imune inato, as barreiras físicas do úbere, incluindo a pele, o esfíncter do teto e a queratina, trabalham juntos para impedir a entrada de bactérias (Thompson-Crispi et al, 2014a).…”

Section: Defesas Anatômicasunclassified

“…O gene BoLA (Bovine Lymphocyte Antigen) tem sido amplamente estudado nos últimos 20 anos em razão de sua influência sobre as características produtivas e às relacionadas à saúde animal, localiza-se no Complexo Principal de Histocompatibilidade (MHCMajor Histocompatibility Complex) do genoma bovino e que são altamente polimórficos, estão envolvidos nos processos celulares de resistência ou suscetibilidade à mastite (Rupp et al, 2007), CCS (Pashmi et al, 2009;Chu et al, 2012), e resposta imunitária (Thompson-Crispi et al, 2014a).…”

Section: Busca Por Genes Candidatosunclassified

Melhoramento genético visando à resistência a mastite em bovinos leiteiros

et al. 2014

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ADDITIONAL KEYWORDSImmunity. Genetic parameters. RESUMOCom essa revisão, objetivou-se traçar a trajetória dos estudos sobre as características físicas, ambientais e genéticas de resistência à mastite. Uma característica complexa e multifatorial pode ser adquirida por traumas físicos, alterações fisiológicas e metabólicas, microrganismos patogênicos ambientais ou contagiosos e por componentes genéticos envolvidos na resposta imune. As maiores perdas estão relacionadas à diminuição da produção e qualidade do leite, menores ganhos genéticos anuais e baixa intensidade de seleção, sendo citada como a principal doença da bovinocultura leiteira.Diante disso, novos critérios de seleção foram estabelecidos para aumentar a produção de leite e a resistência à mastite, além da melhoria do ambiente. Estudos genômicos têm sido recomendados quando há dificuldade na coleta de dados fenotípicos e a herdabilidade da característica avaliada é baixa.Além do mais, eles são utilizados como ferramenta auxiliar ao melhoramento genético clássico para aumentar a resistência genética a doenças e desenvolver soluções tecnológicas inovadoras. Muitos trabalhos foram realizados para identificar e estudar genes candidatos envolvidos na resposta de resistência à mastite que estão correlacionadas com lócus de características quantitativas (QTL -Quantitative Trait Loci) em programas de seleção assistida por marcadores moleculares. Isto permite a seleção mais rápida e precisa de bovinos pelo seu valor genético genômico, estimado a partir de equações de predição, tornando o melhoramento genético um componente de uma estratégia de longo prazo para o aumento da resistência à mastite e melhoria da qualidade do leite.

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A genome-wide association study of immune response traits in Canadian Holstein cattle

Cited by 68 publications

References 57 publications

Genomic response to natural selection within alpine cattle breeds

Genomic response to natural selection within alpine cattle breeds

Transcriptome profiles of whole blood in Italian Holstein and Italian Simmental lactating cows diverging for genetic merit for milk protein

Melhoramento genético visando à resistência a mastite em bovinos leiteiros

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