A Genome-Wide Association Study in Koreans Identifies Susceptibility Loci for Allergic Nickel Dermatitis

Kim, Dae Suk; Kim, Dong Hyun; Lee, Hemin; Jee, Hyunseok; Lee, Young; Chang, Min Youl; Kwak, Taek Jong; Kim, Chul Hong; Shin, Young Ah; Lee, Jeung Hoon; Yoon, Tae Jin; Lee, Min Geol

doi:10.1159/000353235

Cited by 7 publications

(4 citation statements)

References 16 publications

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“…Kim et al. (2013) performed a genome‐wide study on susceptibility loci for allergic nickel dermatitis. NTN4 (encoding for and extracellular matrix molecule) and PELI1 (involved in TLR/IL‐1R signalling) seem to be involved in nickel sensitisation.…”

Section: Assessmentmentioning

confidence: 99%

“…This toxicity may be important in relation to the immune system or in terms of bacterial defence if the toxic concentrations could be achieved in vivo. Kim et al (2013) performed a genome-wide study on susceptibility loci for allergic nickel dermatitis. NTN4 (encoding for and extracellular matrix molecule) and PELI1 (involved in TLR/IL-1R signalling) seem to be involved in nickel sensitisation.…”

Section: Immunotoxic Activity Of Nickelmentioning

confidence: 99%

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Update of the risk assessment of nickel in food and drinking water

Schrenk¹,

Bignami²,

Bodin³

et al. 2020

EFS2

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The European Commission asked EFSA to update its previous Opinion on nickel in food and drinking water, taking into account new occurrence data, the updated benchmark dose (BMD) Guidance and newly available scientific information. More than 47,000 analytical results on the occurrence of nickel were used for calculating chronic and acute dietary exposure. An increased incidence of postimplantation loss in rats was identified as the critical effect for the risk characterisation of chronic oral exposure and a BMDL 10 of 1.3 mg Ni/kg body weight (bw) per day was selected as the reference point for the establishment of a tolerable daily intake (TDI) of 13 lg/kg bw. Eczematous flare-up reactions in the skin elicited in nickel-sensitised humans, a condition known as systemic contact dermatitis, was identified as the critical effect for the risk characterisation of acute oral exposure. A BMDL could not be derived, and therefore, the lowest-observed-adverse-effect-level of 4.3 lg Ni/kg bw was selected as the reference point. The margin of exposure (MOE) approach was applied and an MOE of 30 or higher was considered as being indicative of a low health concern. The mean lower bound (LB)/upper bound (UB) chronic dietary exposure was below or at the level of the TDI. The 95th percentile LB/UB chronic dietary exposure was below the TDI in adolescents and in all adult age groups, but generally exceeded the TDI in toddlers and in other children, as well as in infants in some surveys. This may raise a health concern in these young age groups. The MOE values for the mean UB acute dietary exposure and for the 95th percentile UB raises a health concern for nickel-sensitised individuals. The MOE values for an acute scenario regarding consumption of a glass of water on an empty stomach do not raise a health concern.

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Section: Assessmentmentioning

confidence: 99%

Section: Immunotoxic Activity Of Nickelmentioning

confidence: 99%

Update of the risk assessment of nickel in food and drinking water

Schrenk¹,

Bignami²,

Bodin³

et al. 2020

EFS2

View full text Add to dashboard Cite

show abstract

“…Regarding the HLA system in asthma, the most frequently associated haplotype in Spanish population is DRB1*01 [ 59 ]. In contact dermatitis, various loci conferring susceptibility to nickel dermatitis have been described [ 60 ].…”

Section: Discussionmentioning

confidence: 99%

Comorbidity of Narcolepsy Type 1 With Autoimmune Diseases and Other Immunopathological Disorders: A Case-Control Study

Martínez-Orozco

Vicário²,

Andrés

et al. 2016

J Clin Med Res

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BackgroundSeveral evidences suggest that autoimmune diseases (ADs) tend to co-occur in an individual and within the same family. Narcolepsy type 1 (NT1) is a chronic sleep disorder caused by a selective loss of hypocretin-producing neurons due to a mechanism of neural destruction that indicates an autoimmune pathogenesis, although no evidence is available. We report on the comorbidity of ADs and other immunopathological diseases (including allergy diseases) in narcolepsy.MethodsWe studied 158 Caucasian NT1 patients (60.7% male; mean age 49.4 ± 19.7 years), in whom the diagnosis was confirmed by polysomnography followed by a multiple sleep latency test, or by hypocretin-1 levels measurements.ResultsThirty out of 158 patients (18.99%; 53.3% female; 29 sporadic and one familial cases) had one or more immunopathological diseases associated. A control group of 151 subjects were matched by gender and age with the narcolepsy patients. Results demonstrated that there was a higher frequency of ADs in our series of narcolepsy patients compared to the sample of general population (odds ratio: 3.17; 95% confidence interval: 1.01 - 10.07; P = 0.040). A temporal relationship with the age at onset of the diseases was found.ConclusionsCataplexy was significantly more severe in NT1 patients with immunopathological diseases, and immunopathological diseases are a risk factor for severe forms of cataplexy in our series (odds ratio: 23.6; 95% confidence interval: 5.5 - 100.1).

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“…3 Our current knowledge regarding the impact of genetic polymorphisms on contact dermatitis is largely a result of multiple candidate gene-specific studies, with limited wholegenome expression analyses and genome-wide association study approaches. 3,4 Importantly, most previous studies have addressed the genetic susceptibility in sensitization, but the ensuing development of dermatitis has seldom been interrogated. Determining the underlying genetics of the subsequent inflammatory response is of particular relevance, because this is directly responsible for patients' symptoms.…”

Section: To the Editormentioning

confidence: 99%