A genetic variant in pre-miR-27a is associated with a reduced breast cancer risk in younger Chinese population

Zhang, Ning; Huo, Qiang; Wang, Xiaolong; Chen, Xi; Li, Long; Jiang, Liyu; Ma, Tingting; Yang, Qifeng

doi:10.1016/j.gene.2013.07.041

Cited by 41 publications

(36 citation statements)

References 36 publications

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“…Twenty-five abstracts were retrieved through the search "miR-27a", "polymorphism" and "cancer", and eleven articles were identified as eligible studies (Sun et al, 2010;Yang et al, 2010;Catucci et al, 2012;Hezova et al, 2012;Shi et al, 2012;Zhang et al, 2012;Zhou et al, 2012;Wei et al, 2013;Zhang et al, 2013;Xiong et al, 2014;Yang et al, 2014). Out of the Twenty-five, seven articles were pooled analysis, commentary and review papers (Wang et al, 2012;Yang and Burwinkel, 2012;Ma et al, 2013;Wang et al, 2013;Xu et al, 2013b;Zhong et al, 2013;Chen et al, 2014), and four reports were cancer biology experimental studies (Hirota et al, 2012;Jahid et al, 2012;Zanetti et al, 2012;Yuan et al, 2013).…”

Section: Characteristics Of Studiesmentioning

confidence: 99%

“…As a result, a total of seventeen studies met the inclusion criteria and were identified as eligible studies (Figure 1). Totally, 7,813 cases and 9,602 controls were included from seventeen studies, including five studies for breast cancer with 3,099 cases and 3,697 controls (Yang et al, 2010;Zhang, 2011;Catucci et al, 2012;Zhang et al, 2012;Zhang et al, 2013), five for gastric cancer with 1,776 cases and 2,350 controls (Sun et al, 2010;Zhou et al, 2012;Xu et al, 2013b;Kupcinskas et al, 2014;Yang et al, 2014), two for colorectal cancer with 660 cases and 680 controls (Hezova et al, 2012;Zhang, 2012), and one for esophageal cancer (Wei et al, 2013), live cancer (Li, 2011), nasopharyngeal cancer (Li, 2011), renal cancer (Shi et al, 2012) or cervical cancer (Xiong et al, 2014). For ethnic distribution, in addition to four studies on Caucasian descent, including two for breast cancer (Yang et al, 2010;Catucci et al, 2012), one for gastric cancer (Kupcinskas et al, 2014) and one for colorectal cancer (Hezova et al, 2012), there were thirteen studies of Asian origin.…”

Section: Characteristics Of Studiesmentioning

confidence: 99%

“…Due to limited studies and data presented in original reports, however, these meta-analysis studies did not calculate the pooled odd ratio (OR) for different subgroups of breast cancers or other types of cancers. Furthermore, recent studies showed controversial results on the association of rs895819 with cancer risk (Wei et al, 2013;Zhang et al, 2013;Kupcinskas et al, 2014;Xiong et al, 2014;Yang et al, 2014). To clarify the association between rs895819 and cancer risk, in this study, we performed additional pooling analyses by including more recent publications to improve the efficiency of meta-analysis.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association of a Pre-miR-27a Polymorphism with Cancer Risk: an Updated Meta-analysis

Bai

Weng²,

Su³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Section: Characteristics Of Studiesmentioning

confidence: 99%

Section: Characteristics Of Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association of a Pre-miR-27a Polymorphism with Cancer Risk: an Updated Meta-analysis

Bai

Weng²,

Su³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…A research promulgated that chicken gga-miR-202 * was involved in regulating the development of embryonic gonad in chickens [22]. An SNP in pre-miR-27a (rs895819) affects miRNA expression, serves as a risk factor for breast cancer and reduces breast cancer risk in younger Chinese population through genetic variants [23]. The SNP rs2910164 in pre-miR-146 affects the coronary artery disease incidence through a common variant [24].…”

Section: Introductionmentioning

confidence: 99%

Effect of pre-miRNA-1658 gene polymorphism on chicken growth and carcass traits

Jian-zhou

Sun

2016

Asian-Australas J Anim Sci

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ObjectivePolymorphisms occurring in the precursor region of microRNAs (miRNAs) affect the target gene and alter the biogenesis of miRNAs, resulting in phenotypic variation. The purpose of the study was to investigate the genetic effects of rs16681031 (C>G) mutation in the precursor region of gga-miR-1658 on the economic traits of the Gushi-Anka chicken F2 resource population.MethodsTo explore the effect of miR-1658 polymorphisms on chicken economic traits, the SNP was genotyped by MassArray matrix-assisted laser desorption/ionization-time of flight mass spectrometry. The association between the SNP and chicken body size, growth and carcass traits was determined by linear mixed models.ResultsThe SNP was not only significantly associated with body weight at the age of 6, 8, 10, 12 weeks, respectively, but also with the breadth of the chicken chest, body slanting length and pelvic breadth at 4 weeks, chest depth at 8 weeks of age, and body slanting length at 12 weeks (p<0.05), respectively.ConclusionOur data serve as a useful resource for further analysis of miRNA function, and represent a molecular genetic basis for poultry breeding.

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“…Its occurrence and development involves oncogene activation, tumor suppressor gene inactivation and many other related factors. In recent years, many microRNA polymorphisms have been identified as risk factors for breast cancer [29, 30]. …”

Section: Discussionmentioning

confidence: 99%

Association between three functional microRNA polymorphisms (miR-499 rs3746444, miR-196a rs11614913 and miR-146a rs2910164) and breast cancer risk: a meta-analysis

Zhang

Yan

et al. 2016

Oncotarget

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Three functional microRNA polymorphisms (miR-499 rs3746444 A > G, miR-196a rs11614913 C > T and miR-146a rs2910164 G > C) have been reported to be associated with breast cancer (BC) risk. However, the results of the published studies are inconsistent. In order to obtain a more credible result, we conducted this meta-analysis. We searched PubMed, EMBASE and Web of Science databases to identify relevant studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the association. Thirty-eight eligible studies with 17,417 cases and 18,988 controls were included in this meta-analysis. Our results showed that the rs3746444 was associated with an increased breast cancer risk in the four genetic models (G vs. A: OR = 1.17, P = 0.008; GG vs. AA: OR = 1.41, P < 0.001; AG vs. AA: OR = 1.10, P = 0.036; GG+AG vs. AA: OR = 1.16, P = 0.001). In the subgroup analysis by ethnicity, significant correlation remained in Asians but not in Caucasians. For rs11614913, obvious decreased breast cancer risk was observed in Caucasian populations (T vs. C: OR = 0.93, P = 0.044). However, we couldn't detect an association between rs2910164 and breast cancer risk. This meta-analysis demonstrates that rs3746444 could increase breast cancer risk in Asians and in general populations, while rs11614913 could decrease the risk of breast cancer in Caucasians. The rs2910164 polymorphism has no association with breast cancer risk. More multicenter studies with larger sample sizes are required to verify our results.

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A genetic variant in pre-miR-27a is associated with a reduced breast cancer risk in younger Chinese population

Cited by 41 publications

References 36 publications

Association of a Pre-miR-27a Polymorphism with Cancer Risk: an Updated Meta-analysis

Association of a Pre-miR-27a Polymorphism with Cancer Risk: an Updated Meta-analysis

Effect of pre-miRNA-1658 gene polymorphism on chicken growth and carcass traits

Association between three functional microRNA polymorphisms (miR-499 rs3746444, miR-196a rs11614913 and miR-146a rs2910164) and breast cancer risk: a meta-analysis

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