“…Therefore, risk factors for this outcome measure may be used to arrive at individualized treatment strategies (van der Helm-van Mil et al, 2010). It has been shown that genetic variants of IL-15 (Knevel et al 2012), IL4R (Krabben et al, 2013), IL2RA (Knevel et al, 2013a), GZMB (Knevel et al, 2013b), Dkk-1 (de Rooy et al, 2013), MMP-9 (de Rooy et al, 2014), MMP-3 (Knevel et al, 2014a), OPG (Knevel et al, 2014b), PTGER4 (Rodriguez-Rodriguez et al, 2015), TRAF1/C5 as well as the rs2833522 SNP (De Rooy et al, 2013) are associated with RA severity as reflected by radiological damage and joint destruction appeared in RA patients. Moreover, it has been reported that RA patients with the Blimp-1 risk allele show more synovial inflammation than those without this allele (Herenius et al, 2011).…”