2007
DOI: 10.1534/genetics.107.075739
|View full text |Cite
|
Sign up to set email alerts
|

A Genetic Screen Identifies Novel Polycomb Group Genes in Drosophila

Abstract: Polycomb group (PcG) genes encode evolutionarily conserved transcriptional repressors that are required for the long-term silencing of particular developmental control genes in animals and plants. PcG genes were first identified in Drosophila as regulators that keep HOX genes inactive in cells where these genes must remain silent during development. Here, we report the results of a genetic screen aimed at isolating novel PcG mutants in Drosophila. In an EMS mutagenesis, we isolated 82 mutants that show Polycom… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

6
68
0

Year Published

2009
2009
2018
2018

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 83 publications
(74 citation statements)
references
References 56 publications
(64 reference statements)
6
68
0
Order By: Relevance
“…It is also possible that at these loci Jarid2 has a more transient association or even that it is less accessible to interact with the antibodies that we have generated. However, our findings are also in agreement with modifier screens that have been performed in Drosophila to identify major regulators of Polycomb group-mediated phenotypes but that were unable to capture Jarid2 (11).…”
Section: Discussionsupporting
confidence: 90%
“…It is also possible that at these loci Jarid2 has a more transient association or even that it is less accessible to interact with the antibodies that we have generated. However, our findings are also in agreement with modifier screens that have been performed in Drosophila to identify major regulators of Polycomb group-mediated phenotypes but that were unable to capture Jarid2 (11).…”
Section: Discussionsupporting
confidence: 90%
“…A recent systematic genetic screen aimed at isolating Drosophila mutants with PcG phenotypes, identified multiple alleles in most of the already known PcG loci [64]. However, the screen also resulted in the isolation of mutant alleles of genes previously not known to be involved in PcG repression.…”
Section: Still More To Discover: Other Pcg Proteinsmentioning
confidence: 99%
“…7 Like Sce, PR-DUB is required for repression of HOX genes both during embryogenesis and during larval development. 7,44 Given that removal of the Sce E3 ligase that catalyzes H2Aub formation results in loss of HOX gene repression, it may seem paradoxical that removal of PR-DUB and the concomitant increase in H2Aub levels results in the same phenotype. In this context, it is important to note that the level of Sce protein itself is unaffected in embryos that lack PR-DUB.…”
Section: The H2a Deubiquitinase Pr-dub Is Essential For Repression Ofmentioning
confidence: 99%