A genetic risk tool for obesity predisposition assessment and personalized nutrition implementation based on macronutrient intake

Abstract

There is little evidence about genetic risk score (GRS)-diet interactions in order to provide personalized nutrition based on the genotype. The aim of the study was to assess the value of a GRS on obesity prediction and to further evaluate the interactions between the GRS and dietary intake on obesity. A total of 711 seekers of a Nutrigenetic Service were examined for anthropometric and body composition measurements and also for dietary habits and physical activity. Oral epithelial cells were collected for the identification of 16 SNPs (related with obesity or lipid metabolism) using DNA zip-coded beads. Genotypes were coded as 0, 1 or 2 according to the number of risk alleles, and the GRS was calculated by adding risk alleles with such a criterion. After being adjusted for gender, age, physical activity and energy intake, the GRS demonstrated that individuals carrying >7 risk alleles had in average 0.93 kg/m(2) of BMI, 1.69 % of body fat mass, 1.94 cm of waist circumference and 0.01 waist-to-height ratio more than the individuals with ≤7 risk alleles. Significant interactions for GRS and the consumption of energy, total protein, animal protein, vegetable protein, total fat, saturated fatty acids, polyunsaturated fatty acids, total carbohydrates, complex carbohydrates and fiber intake on adiposity traits were found after adjusted for confounders variables. The GRS confirmed that the high genetic risk group showed greater values of adiposity than the low risk group and demonstrated that macronutrient intake modifies the GRS association with adiposity traits.

Cholesteryl Ester Transfer Protein Variant (RS1800777) with Liver Histology in Non-Alcoholic Fatty Liver Disease Patients

“…Environmental determinants of HDL-cholesterol levels (e.g., hormonal status, exercise and dietary fat intake) have been described in the literature [31]. Another hypothesis to explain the association of this SNP with liver damage independently of HDL levels is the lipid postprandial changes, and this is another limitation in our design.…”

Gene-Gene Interplay and Gene-Diet Interactions Involving the <b><i>MTNR1B </i></b>rs10830963 Variant with Body Weight Loss

“…The current study enrolled men and women of Caucasian ancestry, who voluntarily attended community pharmacies in 7 cities of Spain (Barcelona, Zaragoza, La Coruña, Pontevedra, Madrid, Granada and Málaga) [22]. A total of 465 individuals complied with the first follow-up visit.…”

Guide for Current Nutrigenetic, Nutrigenomic, and Nutriepigenetic Approaches for Precision Nutrition Involving the Prevention and Management of Chronic Diseases Associated with Obesity

“…Additionally, studies using genetic risk scores (GRS) have examined the cumulative effect of SNPs on diet interactions and disease susceptibility. Thus, macronutrient intake was shown to modify the association of an obesity GRS with greater values of adiposity [27]. Significant interactions between saturated fat intake and obesity GRS were also found to modulate BMI in two American populations [28].…”