A genetic perspective on the association between exercise and mental health

Geus, Eco J. C. de; Moor, Marleen H. M. de

doi:10.1016/j.mhpa.2008.09.005

Cited by 38 publications

(31 citation statements)

References 115 publications

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“…Genetic pathways, such as pleiotropy or gene-by-exercise interactions, also appear to be possible explanations related to the antidepressant effects of exercise (de Geus and de Moor, 2008).…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Exercise and severe major depression: Effect on symptom severity and quality of life at discharge in an inpatient cohort

Schuch

Vasconcelos-Moreno

Borowsky

et al. 2015

Journal of Psychiatric Research

110

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Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Exercise and severe major depression: Effect on symptom severity and quality of life at discharge in an inpatient cohort

Schuch

Vasconcelos-Moreno

Borowsky

et al. 2015

Journal of Psychiatric Research

110

View full text Add to dashboard Cite

“…The mechanism may be that the gene codes for a product that is, for example, used by various cells, or has a signaling function with respect to various targets. Regular exercise behavior and health outcomes may be partly due to underlying genetic factors that have a favourable effect on both traits [14,28,29]. This explains why some of the associations between baseline physical activity and future occurrence of disease seen in observational studies may be due to genetic pleiotropy (see Fig.…”

Section: Heritability and Genetic Selection In Modifying Relationshipmentioning

confidence: 99%

Physical activity, genes, and lifetime predisposition to chronic disease

Kujala

2011

Eur Rev Aging Phys Act

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This mini-review summarizes the main associations between physical activity and chronic diseases and discusses the basic concepts related to the role of genetic factors in studies evaluating the effects of physical activity/exercise therapy on chronic disease prevention/ treatment during the life course. Many observational cohort studies have shown that high physical activity during young adulthood or middle age is associated with reduced later life morbidity, mobility limitations and mortality. Physical activity or exercise therapy has a positive effect on health via many disease-specific mechanisms. The most consistent finding of the various randomized controlled studies conducted to date is that aerobic/functional capacity and/or muscle strength can be improved by exercise training among patients with different chronic diseases. Genes are known to play a role in chronic disease predisposition and to contribute to physical fitness levels, physical activity participation and ageing. Physical fitness, physical activity and health outcomes may be partly due to underlying genetic factors that have a favourable effect on all these traits (genetic pleiotropy). This means that in observational studies, the relationship between baseline activity and the later occurrence of diseases may not be interpreted entirely as causal. Increased knowledge on the role of nuclear genome, mitochondrial genome, epigenetics, telomeres and regulation of gene expression will increase our understanding of their relationships with physical activity and morbidity.

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“…Mediated moderation can help us find an answer to these questions as it evaluates potential mediators of moderated effects (Baron & Kenny, 1986). Given the commonness of heterogeneous effects of physical activity on mental health (Cerin et al, 2009;Ekkekakis et al, 2005;de Geus & de Moor, 2008), it is important to identify why and how such levels of heterogeneity exist through the application of mediated moderation models.…”

Section: Mediated Moderation and Moderated Mediationmentioning

confidence: 99%

“…Let us assume that genetic characteristics moderate the relationship of physical activity with mental wellbeing, and mood is a hypothetical mediator of such moderated effect (de Geus & de Moor, 2008). It is possible that genetic characteristics modify the effects of physical activity on mental wellbeing by modifying its effect on mood.…”

Section: Mediated Moderation and Moderated Mediationmentioning

confidence: 99%

Ways of unraveling how and why physical activity influences mental health through statistical mediation analyses

Cerin

2010

Mental Health and Physical Activity

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A genetic perspective on the association between exercise and mental health

Cited by 38 publications

References 115 publications

Exercise and severe major depression: Effect on symptom severity and quality of life at discharge in an inpatient cohort

Exercise and severe major depression: Effect on symptom severity and quality of life at discharge in an inpatient cohort

Physical activity, genes, and lifetime predisposition to chronic disease

Ways of unraveling how and why physical activity influences mental health through statistical mediation analyses

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