A genetic linkage map of the human genome

Donis-Keller, Helen; Green, Philip; Helms, Cynthia; Cartinhour, Samuel; Weiffenbach, Barbara; Stephens, Karen; Keith, Tim P.; Bowden, Donald W.; Smith, Douglas R.; Lander, Eric S.; Botstein, David; Akots, Gita; Rediker, Kenneth; Gravius, Thomas C.; Brown, Valerie A.; Rising, Marcia; Parker, Carol E.; Powers, Jody A.; Watt, D.; Kauffman, Erick; Bricker, Angela L.; Phipps, P.; Müller-Kahle, Hans; Fulton, Thomas R.; Ng, Siu Kin; Schumm, James W.; Braman, Jeffrey C.; Knowlton, Robert G.; Barker, David F.; Crooks, Steven M.; Lincoln, S E; Daly, Mark J.; Abrahamson, Jeff

doi:10.1016/0092-8674(87)90158-9

Cited by 771 publications

(194 citation statements)

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“…Finally, it must be noted that sex differences of the scale found in Arabidopsis are to be taken into account in genetic mapping. Perhaps, in cases like these it is advisable to calculate both rf and rf9 along with the average estimate (rf=1-/(1-rf)(1-rf) or rf=v'rfrf9) derived from the F2 analysis (see also Lalouel, 1977;Donis-Keller et a!., 1987). When evaluating the meaning of recombination dependence on sex it is necessary to ascertain mechanisms and genetic control of this phenomenon, its role in population adaptation and possible ways of its evolutionary formation.…”

Section: Discussionmentioning

confidence: 99%

Sex difference in recombination frequency in Arabidopsis

Vizir¹,

Korol²

1990

Heredity

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Sex differences for rf have been studied in all five chromosomes of the Arabidopsis genome. These differences are strongly segment-specific: in some cases the level of crossing over in male and female meiosis was about the same, though for the majority of segments the rfd is significantly higher than rf9. The data are discussed in the light of the hypothesis about the possible mechanisms of plant sex differences for recombination. The necessity of taking into account the rf sex differences in recombination experiments is called for by the fact that male and female meiocytes can react differentially to the same factor.

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Section: Discussionmentioning

confidence: 99%

Sex difference in recombination frequency in Arabidopsis

Vizir¹,

Korol²

1990

Heredity

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“…Indeed, the first large scale effort to produce a human genetic map, was performed mainly using RFLP markers, the best known genetic markers at the time [20]. However, with the generalisation of PCR and the demonstration of Mendelian inheritance of the multiple alleles due to variations in the number of short nucleotide repeats observed at microsatellite loci [50,81], a change in strategy was quickly made and all the successive genetic maps in humans [14,18,82] were based mainly on this new type of marker.…”

Section: Introduction: Older Types Of Molecular Genetic Markersmentioning

confidence: 99%

A review on SNP and other types of molecular markers and their use in animal genetics

et al. 2002

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-During the last ten years, the use of molecular markers, revealing polymorphism at the DNA level, has been playing an increasing part in animal genetics studies. Amongst others, the microsatellite DNA marker has been the most widely used, due to its easy use by simple PCR, followed by a denaturing gel electrophoresis for allele size determination, and to the high degree of information provided by its large number of alleles per locus. Despite this, a new marker type, named SNP, for Single Nucleotide Polymorphism, is now on the scene and has gained high popularity, even though it is only a bi-allelic type of marker. In this review, we will discuss the reasons for this apparent step backwards, and the pertinence of the use of SNPs in animal genetics, in comparison with other marker types.SNP / microsatellite / molecular marker / genome / polymorphism

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“…Probes p5-23, pFSA63, TG38, and CRI-R944 have been described previously (Donis-Keller et al, 1987;Rommens et al, 1988;Jobs et al, 1990;Vortkamp et al, 1991a). The GLI3 cDNA clone was kindly provided by B. Vogelstein (Johns Hopkins University).…”

Section: Methodsmentioning

confidence: 99%