2013
DOI: 10.1016/j.jbi.2012.12.002
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A genetic algorithm–support vector machine method with parameter optimization for selecting the tag SNPs

Abstract: SNPs (Single Nucleotide Polymorphisms) include millions of changes in human genome, and therefore, are promising tools for disease-gene association studies. However, this kind of studies is constrained by the high expense of genotyping millions of SNPs. For this reason, it is required to obtain a suitable subset of SNPs to accurately represent the rest of SNPs. For this purpose, many methods have been developed to select a convenient subset of tag SNPs, but all of them only provide low prediction accuracy. In … Show more

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Cited by 46 publications
(29 citation statements)
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“…Miranda et al [19] proposed a prototype in which multi-objective PSO (MOPSO) and crowding distance mechanism (CDR) was used to select the values of two SVM parameters for classification problems. İlhan et al [20] optimized C and γ parameters of SVM by using PSO algorithm to predict single nucleotide polymorphisms (SNPs).…”
Section: Particle Swarm Optimization (Pso)mentioning
confidence: 99%
“…Miranda et al [19] proposed a prototype in which multi-objective PSO (MOPSO) and crowding distance mechanism (CDR) was used to select the values of two SVM parameters for classification problems. İlhan et al [20] optimized C and γ parameters of SVM by using PSO algorithm to predict single nucleotide polymorphisms (SNPs).…”
Section: Particle Swarm Optimization (Pso)mentioning
confidence: 99%
“…To develop an efficient SVM model, C and r must be carefully predetermined. C determines the trade-offs between the minimization of the fitting error and minimization of the model complexity, and a is the bandwidth of the radial basis function (RBF) kernel (Wu et al 2007;Khazaee and Ebrahimzadeh 2010;Ilhan and Tezel 2013). The PSO method, based on an analogy with the collective motion of biological organisms, is considered a promising research tool worldwide (Lins et al 2012).…”
Section: Previous Workmentioning
confidence: 99%
“…Won et al [35] combined a novel GA-SVM to find features from biological sequences. A particle swarm optimization (PSO) [36] to optimize a GA-SVM method to predict single nucleotide polymorphisms (SNPs) and to select tag SNPs as pointed by Ilhan and Tezel [37] or to solve the heating system planning problem is presented [38]. Zhang et al combined PSO with SVM for classifying magnetic resonance imaging (MRI), brain images [39].…”
Section: State Of the Artmentioning
confidence: 99%