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SNPs (Single Nucleotide Polymorphisms) include millions of changes in human genome, and therefore, are promising tools for disease-gene association studies. However, this kind of studies is constrained by the high expense of genotyping millions of SNPs. For this reason, it is required to obtain a suitable subset of SNPs to accurately represent the rest of SNPs. For this purpose, many methods have been developed to select a convenient subset of tag SNPs, but all of them only provide low prediction accuracy. In the present study, a brand new method is developed and introduced as GA-SVM with parameter optimization. This method benefits from support vector machine (SVM) and genetic algorithm (GA) to predict SNPs and to select tag SNPs, respectively. Furthermore, it also uses particle swarm optimization (PSO) algorithm to optimize C and γ parameters of support vector machine. It is experimentally tested on a wide range of datasets, and the obtained results demonstrate that this method can provide better prediction accuracy in identifying tag SNPs compared to other methods at present.

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Electroencephalogram (EEG) is used routinely for diagnosis of diseases occurring in the brain. It is a very useful clinical tool in the classification of epileptic seizures and the diagnosis of epilepsy. In this study, epilepsy diagnosis has been investigated using EEG records. For this purpose, an artificial neural network (ANN), widely used and known as an active classification technique, is applied. The particle swarm optimization (PSO) method, which does not need gradient calculation, derivative information, or any solution of differential equations, is preferred as the training algorithm for the ANN. A PSO-based neural network (PSONN) model is diversified according to PSO versions, and 7 PSO-based neural network models are described. Among these models, PSONN3 and PSONN4 are determined to be appropriate models for epilepsy diagnosis due to having better classification accuracy. The training methods-based PSO versions are compared with the backpropagation algorithm, which is a traditional method. In addition, different numbers of neurons, iterations/generations, and swarm sizes have been considered and tried. Results obtained from the models are evaluated, interpreted, and compared with the results of earlier works done with the same dataset in the literature.