A generic biokinetic model for predicting the behaviour of the lanthanide elements in the human body

Abstract

Information on the biokinetics of the 15 elements of the lanthanide series, 57La to 71Lu, is too sparse to permit individual development of meaningful biokinetic models to describe the behaviour of each of the elements in humans. The lanthanides show a regular gradation in chemical properties across the series, and animal studies indicate that this is reflected in regular differences in their deposition in tissues such as the liver and skeleton. These regular differences in chemical and biological behaviour have been utilised to construct a generic lanthanide biokinetic model and to define element-specific parameters for each element in the series. This report describes the use of the available biokinetic data for humans and animals to derive the parameters for each of the elements.

Uncertainties in Cancer Risk Coefficients for Environmental Exposure to Radionuclides. An Uncertainty Analysis for Risk Coefficients Reported in Federal Guidance Report No. 13

“…Data on the systemic biokinetics of the lanthanide elements were reviewed by Taylor and Leggett (2003). Knowledge of the behavior of the lanthanide elements comes mainly from studies on laboratory animals, particularly rats.…”

3,4,3-LI(1,2-HOPO): In vitro formation of highly stable lanthanide complexes translates into efficacious in vivo europium decorporation

“…[6][7][8] In addition, 3,4,3-LI(1,2-HOPO) is known to act as an antenna that sensitizes the luminescence of Eu III , a feature that was used recently to determine the solution thermodynamic stability of the corresponding [Eu III (3,4,3-LI(1,2-HOPO))] ¬ complex. 9 In the work presented here, the photophysical properties of the complexes of 3,4,3-LI(1,2-HOPO) formed with metal ions from the whole lanthanide series were probed and characteristic emission sensitization was 30 observed in both the Visible and Near Infra-Red ranges, depending on the complexed metal ion. The use of the antenna effect as a spectroscopic tool was extended to spectrofluorimetric competition titrations, to determine the formation constants of these lanthanide complexes.…”

Updated Mortality Analysis of Radiation Workers at Rocketdyne (Atomics International), 1948–2008

“…updated versions of those models proposed for use in upcoming ICRP documents (2,5,6). The radionuclides with documented intakes included isotopes of uranium, plutonium, americium, calcium, cesium, cerium, zirconium, thorium, polonium, promethium, iodine, zinc, strontium and hydrogen (tritium).…”