Spare parts are key operational assets in order to minimize the unexpected equipment downtimes that may significantly impact the company results.Accordingly, the spare parts supply chain network supports the entire spare parts operations and it is essential to achieve the planned goals. However, traditional literature on spare parts management has not focused on the underlying supply chain network. Thus, this paper studies the integration of supply chain network design and control with traditional spare parts management. In particular, this paper proposes a generic network optimization modelling structure, with simultaneous decisions for warehouse locations and inventory control, allowing to optimize the total costs of the spare parts supply chain network. The generic model is specified based on three inventory control policies widely used in industrial sites, i.e. (s, Q), (R, s, S) and (S-1, S), which are suitable for managing a great variety of spare parts. Furthermore, a decomposition-based solution approach is also proposed based on generalized Benders decomposition. Finally, numerical results obtained from a real-world case of application on the process industry are shown and discussed.