A general strategy towards personalized nanovaccines based on fluoropolymers for post-surgical cancer immunotherapy

Xu, Jun; Lv, Jia; Zhuang, Qi; Yang, Zongjin; Cao, Zhiqin; Xu, Ligeng; Pei, Pei; Wang, Chao; Wu, Hanfei; Dong, Ziliang; Chao, Yu; Yang, Kai; Peng, Rui; Cheng, Yiyun; Liu, Zhuang

doi:10.1038/s41565-020-00781-4

Cited by 389 publications

(314 citation statements)

References 39 publications

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“…However, the main problem associated with the release of this protein is its instability and cytotoxicity following systemic administration in rodents and in clinical studies. Therefore, gene delivery systems based on nanoparticles could be effective in this sense, both for the high penetrability of the tissues and for their cellular uptake [99].…”

Section: Nanotechnologies and Immunotherapy In Melanomamentioning

confidence: 99%

Recent Advances in Nanotechnology for the Treatment of Melanoma

et al. 2021

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Melanoma is one of the most aggressive forms of skin cancer, with few possibilities for therapeutic approaches, due to its multi-drug resistance and, consequently, low survival rate for patients. Conventional therapies for treatment melanoma include radiotherapy, chemotherapy, targeted therapy, and immunotherapy, which have various side effects. For this reason, in recent years, pharmaceutical and biomedical research has focused on new sito-specific alternative therapeutic strategies. In this regard, nanotechnology offers numerous benefits which could improve the life expectancy of melanoma patients with very low adverse effects. This review aims to examine the latest advances in nanotechnology as an innovative strategy for treating melanoma. In particular, the use of different types of nanoparticles, such as vesicles, polymers, metal-based, carbon nanotubes, dendrimers, solid lipid, microneedles, and their combination with immunotherapies and vaccines will be discussed.

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Section: Nanotechnologies and Immunotherapy In Melanomamentioning

confidence: 99%

Recent Advances in Nanotechnology for the Treatment of Melanoma

et al. 2021

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“…Comparing to traditional cancer vaccines, this strategy is flexible to different types of tumors and more effective in triggering anti-tumor immune responses. More recently, we also took advantage of the antigens on tumor cell membranes to develop personalized anti-tumor immunotherapy for inhibit post-surgery tumor metastasis [70]. B16-OVA cancer cell membrane was collected from tumor bearing mice, then mixed with fluoroalkane-grafted polyethyleneimine (F-PEI) to produce personalized cancer nanovaccines.…”

Section: Tumor Cell Membrane Coated Nanoparticlesmentioning

confidence: 99%

Biological membrane derived nanomedicines for cancer therapy

et al. 2021

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The development of nanomedicine systems for applications in cancer therapies has been widely explored in the last decade. With inherent biocompatibility, nanomedicine devices derived from biological membranes have shown many unique advantages compared with traditional artificial nanomaterials for biomedical applications. Herein, we present a comprehensive review of the recent development of cell membrane derived nanomedicines in cancer treatment. We firstly outline the advantages of biological membranes in nanomedicine design derived from their intrinsic characteristics, and then discuss the applications of biological membrane derived nanomedicines. For the first major category of membrane-derived nanomedicine, synthetic nanoparticles are usually camouflaged with cell membranes to acquire additional functionalities. The other type of membrane-based nanomedicine is directly using the engineered cell membrane-derived vesicles or nanovesicles secreted by cells for tumor treatment. At last, we discuss the challenges of membrane-derived nanomedicines towards future clinical applications, following with perspectives on possible solutions to the current problems.

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“…[29] Other than these methods, fluorination is a widely accepted method that significantly improves the transfection efficacy of DNA, siRNA, miRNA, proteins, and peptides owing to the presence of a unique fluorine effect during transfection. [20,[30][31][32][33][34] In this study, heptafluorobutyric anhydride was used to modify the dendrimer PAMAM to synthesize a derivative fluoropolymer (FP), which was then used for miR-23b delivery to examine the efficacy of regulation of osteogenic differentiation Emerging evidence suggests that microRNAs (miRNAs) play key roles in the regulation of multiple biological processes, including the differentiation of osteoblasts. Although miRNA-based gene therapy holds immense potential in the treatment of a variety of diseases, the intracellular delivery of miRNA remains challenging owing to the lack of efficient and safe gene carriers.…”

Section: Doi: 101002/mabi202100024mentioning

confidence: 99%

“…Notably, FP/miR-23b nanoparticles exhibited a higher transfection efficiency compared to PAMAM/miR-23b that was attributed to the unique fluorine effect during gene transfection. [20,[30][31][32][33][34] Further, the intracellular distribution of FP/ miR-23b nanoparticles was investigated using confocal laser scanning microscopy (CLSM) to test their capability of endosomal escape, which is important for execution of the miR-23b functions in the cytosol (Figure 2). Clear, co-location pattern of green and red fluorescence was observed after miR-23b transfection for 3 and 6 h, indicating that the FP/miR-23b nanoparticles were internalized by the cells and trapped in the lysosomes.…”

Section: Fp-mediated Mir-23b Delivery In Mg-63 Cellsmentioning

confidence: 99%

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Fluoropolymer‐Mediated Intracellular Delivery of miR‐23b for the Osteocyte Differentiation in Osteoblasts

Wang

Xing

Xiong

et al. 2021

Macromolecular Bioscience

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Emerging evidence suggests that microRNAs (miRNAs) play key roles in the regulation of multiple biological processes, including the differentiation of osteoblasts. Although miRNA‐based gene therapy holds immense potential in the treatment of a variety of diseases, the intracellular delivery of miRNA remains challenging owing to the lack of efficient and safe gene carriers. In this study, a fluoropolymer (FP) is constructed through the modification of polyamidoamine (PAMAM) using heptafluorobutyric anhydride and then is used as a carrier for miR‐23b transfection to induce osteocyte differentiation of osteoblasts. The derivative FP is found to facilitate miR‐23b transfection due to its favorable endosomal escape from the "proton sponge" effect. Compared to PAMAM/miR‐23b, the FP/miR‐23b nanocomplex efficiently promotes the differentiation of osteoblasts and formation of calcified nodules, attributable to enhanced expression of various osteogenesis genes (runt‐related transfection factor 2 [RUNX2], alkaline phosphatase [ALP], osteopontin [OPN], and osteocalcin [OCN]). Thus, FP‐mediated miR‐23b transfection may be used as an effective strategy to facilitate osteogenic differentiation.

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A general strategy towards personalized nanovaccines based on fluoropolymers for post-surgical cancer immunotherapy

Cited by 389 publications

References 39 publications

Recent Advances in Nanotechnology for the Treatment of Melanoma

Recent Advances in Nanotechnology for the Treatment of Melanoma

Biological membrane derived nanomedicines for cancer therapy

Fluoropolymer‐Mediated Intracellular Delivery of miR‐23b for the Osteocyte Differentiation in Osteoblasts

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