A general method of detecting additive, dominance and epistatic variation for metrical traits I. Theory

Kearsey, M. J.; Jinks, J L

doi:10.1038/hdy.1968.52

Cited by 219 publications

(184 citation statements)

References 4 publications

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“…The first test (Test I a) is that given by Kearsey and Jinks (1968) and can be presented as a variance ratio (A)…”

Section: Tests Of Epistasismentioning

confidence: 99%

“…Tun triple test cross (Kearsey and Jinks, 1968) and its various modifications and extensions (Jinks, Perkins and Breese, 1969;Jinks and Perkins, 1970;Perkins and Jinks, 1970) are among the best designs available for the study of the genetical architecture of randomly breeding populations. These designs provide separate tests for, and estimates of the additive, dominance and epistatic components of variability but the presence of additive or dominance components can only be tested for unambiguously and unbiased estimates obtained in the absence of epistasis.…”

Section: Introductionmentioning

confidence: 99%

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The efficiency and optimal size of triple test cross designs for detecting epistatic variation

Pooni¹,

Jinks²

1976

Heredity

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“…The first test (Test I a) is that given by Kearsey and Jinks (1968) and can be presented as a variance ratio (A)…”

Section: Tests Of Epistasismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The efficiency and optimal size of triple test cross designs for detecting epistatic variation

Pooni¹,

Jinks²

1976

Heredity

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“…The breeding value of a cross in respect of its production of superior recombinant inbred lines by pedigree inbreeding, single seed descent and dihaploidy can be readily and reliably predicted (Jinks andPooni, 1976, 1980;Jinks, 1978, 1981) using the basic generations and triple test cross families (Mather and Jinks, 1982;Kearsey and Jinks, 1968;Pooni and Jinks, 1979). The best of these recombinant inbreds may themselves be the appropriate end product of the breeding programme.…”

Section: Introductionmentioning

confidence: 99%

Predicting the properties of second cycle hybrids produced by intercrossing random samples of recombinant inbred lines

1984

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SUMMARYDistributive properties of the second cycle hybrids that are produced by intercrossing the recombinant inbreds extractable from the F2 of a cross between two pure breeding lines can be predicted from the early generations of the original cross. Hence the frequency of such hybrids that will outperform the extreme recombinant inbreds or the original F1 can be predicted. Basic generations and triple test cross families provide the most reliable estimates of the predictors and therefore should be used whenever possible although, in the presence of linkage, randomly mated F2's may give improved predictions. Simpler experiments consisting of the parental varieties and their F1 and F2 generations, however, provide all the information that is likely to be necessary for most practical purposes.The predictive power of the new approach is demonstrated on material extracted from the cross of varieties I and 5 of Nicotiana rustica. The predictors were estimated from the means and variances of V1, V5, F1 and F2 raised in six environments between 1973 and 1983. The predicted frequencies of second cycle F1's which outperform the extreme recombinant inbred lines derived from this cross are compared with those observed among 190 second cycle hybrids in a diallel between 20 recombinant inbreds derived from the same cross.

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“…In all circumstances, however, it is a test of the adequacy of a simple additive-dominance model which assumes that there is no epistasis and that the testers have no common alleles. The confounding of epistasis and dominance when the testers do not satisfy this requirement does not apply to the more general test for epistasis in the full triple test-cross analysis of Kearsey and Jinks (1968).…”

Section: Theorymentioning

confidence: 99%

“…JINKS, PERKINS AND BREESE (1969) have described a simplified version of the triple test-cross of Kearsey and Jinks (1968) in which the L3 families (testcrosses to an F1 tester) are replaced by P families (selfs of the population under test). The use of this simplified version is restricted to populations of pure-breeding lines, so that the P families are the pure-breeding lines themselves, and the analysis yields unambiguous results only if the L1 and L2 pure-breeding testers differ at all the k loci at which individuals in the population may differ.…”

Section: Introductionmentioning

confidence: 99%

The consequences of using inadequate testers in the simplified triple test-cross

Virk

Jinks

1977

Heredity

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SUMMARYThe genetieal consequences of common alleles in the L1 and L5 testers of a simplified version of the triple test-cross which is applicable to populations of inbred lines are examined. The test for epistasis under these circnsnstances becomes ambiguous and can spuriously detect non-allelie interactions when they may not exist although it still provides a test for epistasis and the adequacy of the testers simultaneously. The tests of significance and the estimates of additive variation are biased to an extent related to the dominance and dominance x additive effects of the common mci while the significance and estimates of dominance variatinn are deflated because they reflect the dominance effects at the non-common loci only. The covariance of sums and differences is also underestimated for the same reasons. These expectations are illustrated by analysing the 190 simplified triple test-crosses that could be extracted from a 20 x 20 diallel set of crosses between pure-breeding lines of jVicotiana rustira.

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A general method of detecting additive, dominance and epistatic variation for metrical traits I. Theory

Cited by 219 publications

References 4 publications

The efficiency and optimal size of triple test cross designs for detecting epistatic variation

The efficiency and optimal size of triple test cross designs for detecting epistatic variation

Predicting the properties of second cycle hybrids produced by intercrossing random samples of recombinant inbred lines

The consequences of using inadequate testers in the simplified triple test-cross

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