A general method for the isolation of naturally occurring water-soluble bases

Ghosal, Shibnath; Banerjee, Putul; Banerjee, S.

doi:10.1016/s0031-9422(00)85157-2

Cited by 27 publications

(7 citation statements)

References 8 publications

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“…The aqueous layer, after extraction with ether and ethyl acetate, was treated with saturated solution of ammonium reineckate at pH ca. 8 [16]. The reineckate salt was collected by filtration.…”

Section: Treatment Of Aqueous Portionmentioning

confidence: 99%

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Alkaloid Constituents ofSida acuta,S. humilis,*S. rhombifoliaandS. spinosa

Prakash¹,

Varma²,

Ghosal³

1981

Planta Med

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Three types of alkaloidal constituents, viz., beta-phenethylamines, quinazolines and carboxylated tryptamines, in addition to choline and betaine have been isolated from Sida acuta Burm., S. humilis Willd., S. rhombifolia L., and S. spinosa L. and characterized by their physical and spectral properties, and by chemical transformations. The qualitative and quantitative variations in the alkaloidal constituents of roots and aerial portions at different stages of growth were also noted. Elaboration of the quinazoline alkaloids seems to be a characteristic feature of this genus. The favourable combination of sympathomimetic amines and vasicinone in these species would account for their major therapeutic uses in the Indian system of medicine.

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Section: Treatment Of Aqueous Portionmentioning

confidence: 99%

“…The aqueous filtrate from the above was acidified (pH ca. 2) and again treated with a saturated solution of ammonium reineckate [16]. The base reineckates were converted [8] to the corresponding hydrochlorides by stirring the EtOH solution with Amberlite IRA-400 (Cr) resin for 8 hrs.…”

Section: Hypaphorine Methyl Estermentioning

confidence: 99%

Alkaloid Constituents ofSida acuta,S. humilis,*S. rhombifoliaandS. spinosa

Prakash¹,

Varma²,

Ghosal³

1981

Planta Med

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“…T h e alkaloid mixture from the alcoholic extract was broadly divided into three categories, according to a previously described procedure (GHOSAL et al, 1970), viz., CHCl,rsolub!e acetates, CHC1,-soluble moderately strong bases, and water-soluble bases. light petrol.…”

Section: Methodsmentioning

confidence: 99%

“…Gradient-pH extraction (GHOSAL et al, 1970), fractionation into phenolic and non-phenolic bases over Amberlite IRA-400 resin columns (LUNDSTROM and AGURELL, 1967), precipitation of reineckate salts of water-solubie alkaloids under basic and acidic conditions, and regeneration of the bases over De-Acidite FF (GHOSAL et al, 1970), resulted in the isolation of seven 0-phenethylamines (I-VlI) and one tetrahydroisoquinoline ( derivatives with those reported in the literature, mixed melting points, co-TLC with authentic reference materials, by the usual chemical transformations into known compounds, and from the spectral (UV, IR, PMR,lMS) properties. Gradient-pH extraction (GHOSAL et al, 1970), fractionation into phenolic and non-phenolic bases over Amberlite IRA-400 resin columns (LUNDSTROM and AGURELL, 1967), precipitation of reineckate salts of water-solubie alkaloids under basic and acidic conditions, and regeneration of the bases over De-Acidite FF (GHOSAL et al, 1970), resulted in the isolation of seven 0-phenethylamines (I-VlI) and one tetrahydroisoquinoline ( derivatives with those reported in the literature, mixed melting points, co-TLC with authentic reference materials, by the usual chemical transformations into known compounds, and from the spectral (UV, IR, PMR,lMS) properties.…”

Section: Chemistrymentioning

confidence: 99%

THE ACTIVE PRINCIPLES OFALHAGI PSEUDALHAGI:β–PHENETHYLAMINE AND TETRAHYDROISOQUINOLINE BASES

Ghosal¹,

Srivastava²,

Bhattacharya³

et al. 1974

Planta Med

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From the stems of Alhagi pseudalhagi (BIEB.) DESV. (Leguminosae, Lotoidae), seven ,B-phenethylamines and one tetrahydro-isoquinoline were isolated. T h e compounds were identified by m.p. of the parent compounds and their derivatives, where possible, co-TLC with authentic markers, and spectral properties. T h e alkaloids are ,B-phenethylamine ( I ) , N-methyl-p-phenethylamine (Il), N-methyltyramine (Ill), hordenine (IV), 3 : 4-dihydroxy-p-phenethyltrirnethylammonicrm hydroxide (V), 3-methoxy-4-hydroxy-,!?-phenethyltrimethylammonium hydroxide (Vl), N-methylmescaline (VII), and salsolidine (VIII). This is the first report of occurrence of (VI) in nature and of any 3,4,5-trioxygenated ,B-phenethylamine, e.g., (VII), in the family Leguminosae. The roots afforded essentially the same alkaloids as the stems but in different quantities. The phylogenetic significance o f the cooccurrence o f the eight alkaloids in a single plant species, A. pseudalhagi, is appraised in the light of ,,parallelism" and complexities int/olved. Detailed pharmacological screening of the total alkaloids from the stems were conducted which showed essentially sympathotnimetic activity. The results would further seem to indicate that the therapeutic properies ascribed to the plant extracts are due to the contained alkaloids.In connection with search for active principles of Indian medicinal plants (GHOSAL, 1972), we had occasion to investigate the alkaloidal' constituents of Alhagi pseudalhagi (BIEB.) DESV. (Syn. A. camelorum FISCH., A. maurorum BAKER) Leguminosae: Lotoidae). A. psertdalhagi is a low erect shrub, widely distributed in the gangetic plains of India. The plant is bitter and acrid with a distinct flavour and finds uses in the Indian system of medicine for a variety of purposes (KIRTIKAR and BASU, 1932;CHOPRA et al., 1956). The extracts of the stems and roots are used as a refrigerant, an antipyretic, as a stimulant, laxative, diuretic, and in the treatment of certain brain affection and bronchitis. Interest for the detailed chemical and pharmacological evaluation of the plant was piqued Downloaded by: University of Illinois. Copyrighted material.

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“…β-sitosterol, acylsteryglycoside sitoindoside [5], ephedrine, [25], S-(+)-Nbmethyltryptophan methylester, hypaphorine [3], vasicinone [26], vascicine, and vasicinol [6]. The roots contain 0.06% of alkaloid.…”

Section: Rootmentioning

confidence: 99%

Phyto-Pharmacological Properties of Sida Cordifolia: A Review of Folklore Use and Pharmacological Activities

Khurana

Sharma

Patil

et al. 2016

Asian J Pharm Clin Res

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Plants have been considered to be useful as a medicine for treating different ailments and improving health conditions, since ancient times. The plants as herbal drugs lay down an important foundation of different, well recognized, ancient, and traditional healthcare systems in India as well as other parts of the world. In India, plants constitute an important and indispensable role in different ancient healthcare systems such as Ayurveda, Siddha, Unani, Naturopathy, and Homeopathy. In Ayurveda system of medicine, one of the Rasayana plants having a great medicinal importance is Sida cordifolia belonging to the family Malvaceae. It is an annual undershrub found throughout the tropical and subtropical regions of India. It has been used since ancient times for various ailments in Ayurveda system of medicine. It has numerous folklore uses in different pathological conditions. The plant also reported to possess a number of important pharmacological activities. The present review focused on all these folklore use of this herb along with its reported pharmacological activities.

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A general method for the isolation of naturally occurring water-soluble bases

Cited by 27 publications

References 8 publications

Alkaloid Constituents ofSida acuta,S. humilis,*S. rhombifoliaandS. spinosa

Alkaloid Constituents ofSida acuta,S. humilis,*S. rhombifoliaandS. spinosa

THE ACTIVE PRINCIPLES OFALHAGI PSEUDALHAGI:β–PHENETHYLAMINE AND TETRAHYDROISOQUINOLINE BASES

Phyto-Pharmacological Properties of Sida Cordifolia: A Review of Folklore Use and Pharmacological Activities

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A general method for the isolation of naturally occurring water-soluble bases

Cited by 27 publications

References 8 publications

Alkaloid Constituents ofSida acuta,S. humilis,S. rhombifoliaandS. spinosa*

Alkaloid Constituents ofSida acuta,S. humilis,S. rhombifoliaandS. spinosa*

THE ACTIVE PRINCIPLES OFALHAGI PSEUDALHAGI:β–PHENETHYLAMINE AND TETRAHYDROISOQUINOLINE BASES

Phyto-Pharmacological Properties of Sida Cordifolia: A Review of Folklore Use and Pharmacological Activities

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Alkaloid Constituents ofSida acuta,S. humilis,*S. rhombifoliaandS. spinosa

Alkaloid Constituents ofSida acuta,S. humilis,*S. rhombifoliaandS. spinosa