This paper presents a Hybrid NC Control System for Automatic line based onCyber-Physical-System (CPS) technology. Firstly, this paper describes the overall system hierarchical structure, which uses a variety of techniques, such as sensors, smart computing, and heterogeneous network integration. In order to improve the practical value, we study and solve some technical problems, such as heterogeneous systems integration, data storage, and real-time simulation. Finally, the prototype system is developed, which has been applied in a large State-owned enterprise in Wuxi, China.