A Gene of the Immunoglobulin H‐Chain Cluster Controls the Murine Antibody Response to Pneumococcal Polysaccharide Type 14

Abstract

Mice of various strains were immunized with pneumococcal polysaccharide type 14 (pneumo-14), and their anti-pneumo-14 antibodies were measured by the Farr test. Mice of strains BALB/c, ST/b, NZB and CBA (Ig allotypes a, e or j) had 300-1700 ng of antibody nitrogen per millilitre of serum on day 7. The corresponding values for C57BL/Ka, RF or AKR mice (allotypes b, c or d) were 40-300 ng/ml. Two families of congenic strains were tested, one with the C57BL and the other with the BALB/c background genome. Their response was either high or low depending on the VH genes, and other gene loci had little effect on the concentration of anti-pneumo-14 antibodies.

Antibody Response to Pneumococcal Polysaccharide Vaccine in Young, Adult and Old Mice

“…These results could explain why no significant reduction in the antibody level to the polyvalent vaccine was measured after neutralization with PnC. The immune response to various polysaccharide antigens has previously been studied in many strains of inbred mice [3][4][5][6][7][8]. Some mouse strains have been characterized as high responders to such antigens while others have been regarded as low responders.…”

“…Some mouse strains have been characterized as high responders to such antigens while others have been regarded as low responders. In our studies for characterizing the antipneumococcal antibody response in adult and young mice, we chose two different inbred mouse strains: BALB/c mice which have been reported to be high responders to polysaccharide antigens [4,5,8] and CBA/J mice which have been reported to give a good anti-polysaccharide immune response in some studies [6,8]. but a poor immune response in others [4].…”

Synthesis and physicochemical and immunological characterization of pneumococcus type 12F polysaccharide-diphtheria toxoid conjugates

“…Types 1, 2, 3, 4, 5, and 7F induce serum antibodies and confer protection against lethal challenge of mice with the homologous type of pneumococcus (26,30). Pnl4 induces serum antibodies in mice, but immunization-induced protection against lethal infection cannot be demonstrated because mice have a high background of "natural" antibodies and are immune to lethal infection with this type (27). Type 6A and type 19F, in contrast, do not elicit serum antibodies in mice (10).…”

ASSOCIATION BETWEEN MATERNAL Gm ALLOTYPE AND NEONATAL SEPTICAEMIA WITH GROUP B STREPTOCOCCI

“…It has been convincingly shown by experiments in mice that the immune responsiveness to dextran and to pneumococcal polysaccharide Type 14, respectively, is controlled by loci closely linked to Ig allotype loci (Blomberg et al, 1972;Makela et al, 1980). As mentioned in the introduction, several studies show that neonatal infections in man with GBS predominantly occurs in infants of mothers who have a low level of type-specific anti-carbohydrate IgG antibodies.…”