A gamma-detecting probe for radioimmune detection of CEA-producing tumors

Abstract

The detection of tumors with radiolabeled antibodies against CEA is possible; however, current nuclear medicine scanning cameras rarely detect tumors smaller than 2 cm in diameter. One of the limitations to tumor detection is the inability to place a detecting camera near a deeply seated intra-abdominal tumor. A hand-held gamma-detecting probe, suitable for intraoperative use, was designed to locate radioactive tumors. Experimental work with CEA-producing colon tumor xenografts in nude mice suggests this probe is more sensitive than external scanners in detecting small tumors. A case report documents the clinical use of this new intraoperative probe.

Role of radioimmunoguided surgery using Iodine-125-labeled B72.3 monoclonal antibody in gastric cancer surgery

“…The properties of this GDP have been extensively described elsewhere [3][4][5][6][7][8]. Patients underwent surgery when counts at the precordial area were ≤10 per second; the mean interval required to reach this level was 19 days from MoAb injection, with a range of 14 to 30 days.…”

“…In 1984, Aitken et al introduced the clinical practice of radioimmunoguided surgery (RIGS) technology for the intraoperative diagnosis and staging of colorectal cancer [3]. They proposed the RIGS system to overcome the many technical limits of immunoscintigraphy and were convinced that this method would improve the intraoperative assessment of tumor staging.…”

“…The first satisfactory results were obtained by using MoAb B72.3 labeled with Iodine-125 (I 125 ). This isotope's long half-life and its low energy emission were thought to provide the optimal conditions for obtaining a measurable high intraoperative tumor-to-normal-tissue (T/NT) count ratio at the tumor sites [3][4][5][6][7][8].…”

Star Trek Meets the Operating Room: Nurse Scotty, Beam Me Up—A Tricorder

“…11 Smaller gamma probes were shown to be capable of localizing tumor foci that accumulated radiolabeled monoclonal antibodies in some instances. 12 Although the monoclonal antibody approaches did not work as well as had been hoped, the probe technology was well adapted to localize, at the time of surgery, sentinel lymph nodes that accumulated 99m Tc sulfur colloid injected in the skin or around tumors, in both melanoma and in breast cancers. This approach is now widely applied clinically by using probe systems specifically designed for the 140-keV photons of 99m Tc.…”

Intraoperative Use of a Portable Large Field of View Gamma Camera and Handheld Gamma Detection Probe for Radioguided Localization and Prediction of Complete Surgical Resection of Gastrinoma: Proof of Concept

“…Our institution has long been on the forefront of radioguided surgery technology [22][23][24][25][26][27][28][29][30][31][32][33] and ZES. 1,2 In the current report, we bring these two together as a proof of concept, describing the use of a LFOVGC and HGDP for realtime intraoperative identification and verification of complete removal of all site of disease in 5 patients (6 cases) presenting with symptomatic ZES.…”