A Further Study of the Influence of Alcohol and Alcoholic Drinks Upon Digestion, With Special Reference to Secretion

Chittenden, R. H.; Mendel, Lafayette B.; Jackson, H.

doi:10.1152/ajplegacy.1898.1.2.164

Cited by 39 publications

(11 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…They confirmed the original report of Chittenden et al (1898), that is, the introduction of alcohol into the stomach resulted in the secretion of acid gastric juice. We also showed the stimulatory effect of ethanol administered intragastrically on gastric acid secretion in dogs.…”

Section: Discussionsupporting

confidence: 84%

Effects of intragastric ethanol administration on gastric acid secretion and gastrointestinal hormone release in dogs.

Imamura

Sasaki

Tsuchiya

et al. 1985

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Dogs with a vagally denervated (Heidenhain) pouch and a gastric fistula were used to investigate the humoral mechanism which would affect the gastric acid secretion following acute intragastric ethanol administration. Ethanol solutions induced a doserelated secretion of gastric acid. Although plasma gastrin levels increased after the loading of both 20% and 30% ethanol solutions, there was a discrepancy between total acid output and the integrated gastrin response. Plasma secretin levels also augmented after the administration of ethanol solutions, with a delay of about one hour after the onset of acid secretion. The response of gastric inhibitory polypeptide (GIP) to ethanol was very slight, similar to that of insulin. There was a significant rise in plasma glucose levels after the instillation of 30% ethanol solution as in the case of liquid meal. It is concluded that gastrin may be merely one of the factors which stimulate acid secretion after ethanol administration, and that gastric acid would have a close relationship with secretin release. It is also probable that acid is not an effecitve stimulant to the release of GIP.intragastric ethanol administration ; gastric acid secretion ; gastrin ; secretin ; GIP Since 1898 (Chittenden et al. ), many investigators have reported the relationship between alcohol intake and gastric acid secretion. However, their results did not always agree. Some persons showed the stimulatory effect of alcohol on gastric acid secretion (Hirschowitz et al. 1956;Woodward et al. 1957;Lenz et al. 1983), others reported the opposite (Cooke 1972;Kuo and Shanbour 1983). Regarding the mechanism by which alcohol affects acid secretion, many factors (such as species differences, route of administration, etc.) have been pointed out by those researchers. Moreover, as remarkable advances in the study of gastrointestinal hormones have been made, some hormones (e.g. gastrin and secretin) have been referred to as substances which mediate the action of alcohol on gastric acid

show abstract

Section: Discussionsupporting

confidence: 84%

Effects of intragastric ethanol administration on gastric acid secretion and gastrointestinal hormone release in dogs.

Imamura

Sasaki

Tsuchiya

et al. 1985

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

show abstract

“…It is about 100 years ago that a stimulatory effect on gastric acid secretion was suggested after uncontrolled experiments with alcohol [57,58] . Beginning in the early 1980s and using systematic and controlled examinations on the effect of pure ethanol and commonly ingested alcoholic beverages on gastric acid secretion, Singer and co-workers [59][60][61][62][63][64][65][66][67] found that the effect of ethanol and alcoholic beverages on gastric acid secretion in healthy humans is differentiated after all.…”

Section: Gastric Acid Secretionmentioning

confidence: 99%

Alcohol-Related Diseases of the Esophagus and Stomach

Franke

Teyssen²,

Singer³

2005

Dig Dis

175

104

View full text Add to dashboard Cite

The present review summarizes the clinically relevant effects of acute and chronic alcohol consumption on motility, mucosal inflammation and cancer of the esophagus and the stomach. Alcohol consumption results in a significant increase in the morbidity of these two organs, the most important probably being the significant increase in the development of esophageal cancer. This review refers to epidemiologic and systematic experimental data to elucidate the clinical impact of alcohol consumption as well as the underlying alcohol-induced pathophysiologic mechanisms for these esophageal and gastric diseases. Much research is still needed to clarify the effects of alcohol itself and the byproducts that result during the production of the different types of alcoholic beverages on dismotility and mucosal injury to the esophagus and stomach.

show abstract

“…Indeed, since the end of the last century [3], it has been accepted that the ingestion of ethanol stimulates gastric secretion. The excitatory mechanism is not entirely clear but several studies suggest that at least two main paths are involved.…”

Section: Abstract the Effects Of Intragastric Administration Of Ethamentioning

confidence: 99%

The Effects of Intragastric Ethanol Administration upon Canine Exocrine Pancreatic Secretion

Tiscornia¹,

Gullo²,

Mott³

et al. 1973

Digestion

View full text Add to dashboard Cite

The effects of intragastric administration of ethanol on exocrine pancreatic secretion were assessed in 11 mongrel dogs provided with gastric and pancreatic fistulae (Thomas cannula). The gastric fistula was left open throughout the experiments to prevent gastric content from entering the duodenum. Ethanol (12% in saline) decreased the protein concentration and the output of basal pancreatic secretion. Ethanol (40% in saline) showed no effect upon pancreatic secretion stimulated by a continuous intravenous injection of GIH secretin (1.0 U/kg/h) but produced a significant increase in protein concentration and output when pancreatic secretion was stimulated by a continuous intravenous injection of Boots secretin (4.0 U/kg/h). Intragastric infusion of 80-percent (v/v) ethanol under intravenous injection of GIH secretin (1.0 U/kg/h) produced an inhibition of the flow rate and alkaline secretion and a significant increase in protein concentration and output. The latter response was suppressed by previous antrectomy.

show abstract

A Further Study of the Influence of Alcohol and Alcoholic Drinks Upon Digestion, With Special Reference to Secretion

Cited by 39 publications

References 0 publications

Effects of intragastric ethanol administration on gastric acid secretion and gastrointestinal hormone release in dogs.

Effects of intragastric ethanol administration on gastric acid secretion and gastrointestinal hormone release in dogs.

Alcohol-Related Diseases of the Esophagus and Stomach

The Effects of Intragastric Ethanol Administration upon Canine Exocrine Pancreatic Secretion

Contact Info

Product

Resources

About