A Further Report on the Cancer Family of Warthin

Hauser, I. Jerome; Weller, Carl Vernon

doi:10.1158/ajc.1936.434

Cited by 77 publications

(22 citation statements)

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“…Colectomy for ''familial polyposis of the colon'' was reported as early as 1901 and seems to have become standard colorectal cancer prevention by no later than 1948 (160,161) in this setting. The cancer history of family G was updated by Warthin in 1925 (162), by Weller and Hauser in 1936 (163), and by Lynch in 1971 (164). In 1977, Lynch first recommended prophylactic, organ-removing surgery based on his studies of heritable cancers (165).…”

Section: Surgical Preventionmentioning

confidence: 99%

Cancer Prevention: From 1727 to Milestones of the Past 100 Years

Lippman¹,

Hawk

2009

Cancer Research

115

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The rich, multidisciplinary history of cancer prevention recounted here begins with surgical and workplace recommendations of the 1700s and ends with 2009 results of the enormous (35,535 men) Selenium and Vitamin E [prostate] Cancer Prevention Trial (SELECT). This history comprises a fascinating array of chemopreventive, vaccine, surgical, and behavioral science research, both preclinical and clinical.

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Section: Surgical Preventionmentioning

confidence: 99%

Cancer Prevention: From 1727 to Milestones of the Past 100 Years

Lippman¹,

Hawk

2009

Cancer Research

115

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“…Warthin wrote a follow up report about cancer family G 12 years later [26], and noted that most of the cancers occurred in the stomach, colon, or uterus. Moreover, two of his colleagues provided additional follow up of this family in 1936 [27].…”

Section: Historical Backgroundmentioning

confidence: 99%

Evolution of the Nomenclature for the Hereditary Colorectal Cancer Syndromes

Boland

2005

Familial Cancer

113

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The hereditary forms of colorectal cancer have been given many names historically as the manifestations have been gradually understood. Lynch syndrome has had several names, most prominently 'Hereditary Nonpolyposis Colorectal Cancer' or HNPCC. Clarification of the genetic basis and full phenotypic expression of this disease mandates a more clinically useful name that clarifies the consideration of non-colonic cancers in a family history, and unifies the diagnosis around the germline mutation in a DNA mismatch repair (MMR) gene. The term 'Lynch syndrome' is proposed for the autosomal dominant disease caused by a germline mutation in a DNA MMR gene.

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“…More than a hundred such families can be collected from the world's literature, but many such reports lose part of their value in that often only affected individuals are indicated. Perhaps the most thoroughly studied cancer family is that twice reported by Dr. Warthin and recently brought up to date by Hauser and myself (6). Of 174 members of this family attaining an age of twenty-five years, 41 developed 43 malignant neoplasms.…”

Section: Clinical Evidence For and Against Intrinsic Factors In Thementioning

confidence: 99%

“…The significance of intrinsic factors, the part played by genes and by extrachromosomal factors, and the mendelian implications, if any, must be worked out separately for each kind of neoplasm. (6) In certain instances neoplasia develops upon morphological or functional abnormalities which are themselves intrinsic and inheritable. Some .…”

Section: Clinical Evidence For and Against Intrinsic Factors In Thementioning

confidence: 99%