Intrinsic Factors in the Etiology of Neoplasms

Weller, Carl Vernon

doi:10.1158/ajc.1937.39

Cited by 6 publications

(3 citation statements)

References 14 publications

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“…For instance, retinoblastoma was one of the first malignancies to be recognized as having hereditary features, and it engendered the characterization of one of the first tumor suppressors genes to be cloned, RB1 (Weller, 1937; Friend et al, 1986). In turn, the retinoblastoma protein, Rb, was found to have crucial roles in cell cycle control and differentiation, and to govern a signaling pathway that is inactivated in most if not all human cancers (Weinberg, 1995; Cobrinik, 2005; Skapek et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Retinoblastoma Has Properties of a Cone Precursor Tumor and Depends Upon Cone-Specific MDM2 Signaling

Fang

Lee

et al. 2009

Cell

205

286

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SUMMARY Retinoblastomas develop due to the loss of the Rb protein, yet the cell type in which Rb suppresses retinoblastoma, and the cellular circuitry that underlies the need for Rb are undefined. Here, we show that retinoblastoma cells express markers of post-mitotic cone precursors, but not markers of other retinal cell types. We also demonstrate that human cone precursors prominently express MDM2 and N-Myc, that retinoblastoma cells require both of these proteins for proliferation and survival, and that MDM2 is specifically needed to suppress ARF-induced apoptosis in cultured retinoblastoma cells. Interestingly, retinoblastoma cell MDM2 expression was regulated by the cone-specific RXRγ transcription factor and a human-specific RXRγ consensus binding site, and proliferation required RXRγ as well as the cone-specific thyroid hormone receptor-β2. These findings provide support for a cone precursor origin of retinoblastoma and suggest that human cone-specific signaling circuitry sensitizes to the oncogenic effects of RB1 mutations.

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Section: Introductionmentioning

confidence: 99%

Retinoblastoma Has Properties of a Cone Precursor Tumor and Depends Upon Cone-Specific MDM2 Signaling

Fang

Lee

et al. 2009

Cell

205

286

View full text Add to dashboard Cite

show abstract

“…Lacassagne, working with various inbred strains of mice of known genetic susceptibility or re¬ fractoriness to cancer, achieved results which varied consistently with the strain, in respect both to the degree to which mammary cancer might be induced by injections of estrogen and to the age at which it was produced. 3. Cancer of the breast in inbred strains of mice with a high spontaneous incidence of mam¬ mary cancer (72 per cent) could be developed in all male and female mice by treatments with estrogen, with tumors appearing at an early age (4 to 10 months).…”

Section: Cancerogenic Agentsmentioning

confidence: 99%

“…3. Added to these are fully indexed data collected from separates and information sent in by individual research workers, approached by a wide correspondence plan.…”

mentioning

confidence: 99%