A functional polymorphism in UGT1A1 related to hyperbilirubinemia is associated with a decreased risk for Crohn's disease

Abstract

The homozygous state of the UGT1A1*28 polymorphism, associated with higher serum bilirubin levels, may be protective for the development of Crohn's disease, suggesting that the anti-oxidant capacity of bilirubin may play a part.

Bilirubin suppresses Th17 immunity in colitis by upregulating CD39

“…Jaundiced patients with concomitant ulcerative colitis and PSC seem to manifest milder or asymptomatic colitis when compared with patients with normal bilirubin levels (10). Similarly, patients with Gilbert syndrome, who have higher levels of UCB because of defective UDP glucuronosyl transferase 1 (UGT1A1), are less likely to develop IBD, further supporting the immunoprotective role of UCB in this condition (11,12). Gunn rats with pronounced defects in UGTA1, an experimental model of Crigler-Najjar syndrome, are likewise relatively resistant to induction of experimental colitis (13).…”

PEGylated bilirubin nanoparticle as an anti-oxidative and anti-inflammatory demulcent in pancreatic islet xenotransplantation

“…Bilirubin has potent anti-oxidant activity by scavenging ROS molecules [24e27]. It also shows anti-inflammatory capability in multiple sclerosis [28], asthma [29], Crohn's disease [30], allergic pneumonitis [31], and autoimmune encephalomyelitis [32]. Based on these cytoprotective effects of bilirubin, previous studies revealed that treatment with bilirubin could not only protect islet cells against oxidative damage during the isolation process, but also induce tolerance to islet cells in syngeneic or allogeneic transplantation [33e35].…”

Синдром Жильбера: Термінологія, Епідеміологія, Генетика, Патогенез (Частина I)

“…Однак останнім часом отримані дані, що пере-конливо свідчать про гетерогенність СЖ, оскільки у хворих із цим захворюванням є ознаки порушен-ня практично всіх етапів обміну білірубіну -від його продукції до виведення з організму [16]:…”