2020
DOI: 10.1186/s40635-020-00331-1
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A functional observational battery for evaluation of neurological outcomes in a rat model of acute bacterial meningitis

Abstract: Background: Acute bacterial meningitis is a disease with a high mortality and a high incidence of neurological sequelae in survivors. There is an acute need to develop new adjuvant therapies. To ensure that new therapies evaluated in animal models are translatable to humans, studies must evaluate clinically relevant and patient-important outcomes, including neurological symptoms and sequelae. Methods: We developed and tested a functional observational battery to quantify the severity of a variety of relevant n… Show more

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“…A functional observational battery (FOB; a method used for over 20 years [ 43 , 44 ]) was employed in order to evaluate the oxaliplatin evoked PN and to give an overall characterization of the animals’ general condition ( Table 2 ). FOB is a neurobehavioral assessment tool, widely used in neurotoxicology studies, which consists of several variable tests and was used to investigate the extent and form (motor and/or sensory) of the evoked neuropathy and the possible effects of GPE administration.…”
Section: Methodsmentioning
confidence: 99%
“…A functional observational battery (FOB; a method used for over 20 years [ 43 , 44 ]) was employed in order to evaluate the oxaliplatin evoked PN and to give an overall characterization of the animals’ general condition ( Table 2 ). FOB is a neurobehavioral assessment tool, widely used in neurotoxicology studies, which consists of several variable tests and was used to investigate the extent and form (motor and/or sensory) of the evoked neuropathy and the possible effects of GPE administration.…”
Section: Methodsmentioning
confidence: 99%