A functional magnetic resonance imaging study of patients with secondary progressive multiple sclerosis

Rocca, Maria A.; Gavazzi, Cinzia; Mezzapesa, Domenico Maria; Falini, Andrea; Colombo, Bruno; Mascalchi, Mario; Scotti, Giuseppe; Comi, Giancarlo; Filippi, Massimo

doi:10.1016/s1053-8119(03)00242-8

Cited by 86 publications

(72 citation statements)

References 50 publications

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“…It is worth noting that in these studies Rocca et al, 2002Rocca et al, , 2003a, increased activation of the contralateral primary SMC was, however, not observed in isolation, but it occurred concomitantly to the recruitment of additional areas of the ''classical'' sensorimotor network, mainly located in the dominant (left) cerebral hemisphere. Conversely, in more disabled patients with RRMS and in those with SPMS, a more bilateral pattern of movementassociated activations has been described [Reddy et al, 2002;Rocca et al, 2003b]. Combined with the results of a cross-sectional study, which compared the brain patterns of activations between adult MS patients at different stages of the disease [Rocca et al, 2005a], these findings suggest that there might be a hierarchy in the adaptive response of the cerebral cortex to the underlying structural damage of MS, characterized, at the beginning of the disease, by an increased activation of areas selectively devoted to the performance of a given task (the contralateral primary SMC in case of motor performance), and later on, by a bilateral activation of the same areas, as well as by the progressive recruitment of additional, more distant areas [Rocca et al, 2005a].…”

Section: Discussionmentioning

confidence: 99%

Is a preserved functional reserve a mechanism limiting clinical impairment in pediatric MS patients?

Rocca¹,

Absinta²,

Ghezzi³

et al. 2008

Human Brain Mapping

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We evaluated the functional magnetic resonance imaging (fMRI) correlates of simple movement performance in patients with pediatric multiple sclerosis (MS) and their relation with the extent of T2 lesion volume (LV), to improve our understanding of the mechanisms leading to their short/medium term favorable clinical course. We obtained fMRI during repetitive flexion-extension of the last four fingers of the right hand and brain dual-echo scans from 17 right-handed patients with pediatric relapsing-remitting MS and 9 sex- and age-matched right-handed healthy controls. T2 LV was measured using a local thresholding segmentation technique. fMRI activations and functional connectivity analysis were performed using SPM2. Compared to controls, pediatric MS patients had an increased recruitment of the left (L) primary sensorimotor cortex (SMC). They also showed reduced functional connectivity between the L primary SMC and the L thalamus (P = 0.03), the L insula and the L secondary sensorimotor cortex (SII) (P = 0.02), the supplementary motor area and the L SII (P = 0.02), the L thalamus and the L insula (P = 0.01) and the L thalamus and the L SII (P = 0.003). In patients with pediatric MS, the activity of the L primary SMC was significantly correlated with brain T2 LV (r = 0.78). No correlation was found between coefficients of abnormal connectivity and structural MRI measures. The maintenance of a selective and strictly lateralized pattern of movement-associated brain activations and a modulation of its functional connections suggest a preserved functional reserve in patients with pediatric MS, which, in turn, might contribute to explain their favorable clinical evolution at short/medium term.

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Section: Discussionmentioning

confidence: 99%

Is a preserved functional reserve a mechanism limiting clinical impairment in pediatric MS patients?

Rocca¹,

Absinta²,

Ghezzi³

et al. 2008

Human Brain Mapping

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“…8,11,[15][16][17][18][19][20][21][22] An increased recruitment of several brain areas with increasing T2 lesion volume (LV) has been shown in patients with RRMS 9,11,23 and primary progressive (PP) MS. Also, the severity of intrinsic T2 lesion damage, measured using T1-weighted images, 24 magnetization transfer (MT), and diffusion tensor (DT) MRI, 19 has been found to modulate the activity of some brain areas. …”

Section: Correlations Between Brain Functional Reorganization and Smentioning

confidence: 99%

Functional MRI in investigating cognitive impairment in multiple sclerosis

Rocca

Meo²,

Filippi

2016

Acta Neurol Scand

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“…Both negative and positive correlations between the fMRI response to active and passive movements and the clinical or MRI measure were separately investigated. Statistical inferences were performed by correcting at voxel level for multiple comparisons within the volumes of interest (VOIs) chosen a priori [22], based on previous fMRI studies that reported significant correlations between the BOLD response to a motor task and clinical or MRI measures in patients with MS [6,8,12,24,28]. Seven VOIs for each hemisphere were selected (see Table 1).…”

Section: ■ Correlation Between Fmri and Clinical And Structural Mri Mmentioning

confidence: 99%

“…■ Key words fMRI · multiple sclerosis · brain · disability · passive movements functional activation with increasing brain pathology measured by MRI [3][4][5][6][7][8]. Since patients performed the motor task with clinically unimpaired limbs, the authors suggested that cortical reorganisation following MS tissue damage has an adaptive role.…”

Section: Introductionmentioning

confidence: 99%

Functional response to active and passive ankle movements with clinical correlations in patients with primary progressive multiple sclerosis

et al. 2006

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Patients with multiple sclerosis (MS) activate a more diffuse cortical network than do healthy subjects when they perform motor tasks. This brain functional reorganisation might contribute to the limiting of disability, but it is unclear whether there is a loss of regional activation in more advanced disease. The aim of this study was to assess whether functional reorganisation diminishes in more disabled patients with primary progressive (PP) MS. The differences in the fMRI response to active and passive movements of the dominant ankle of 13 patients and 16 controls were assessed. The relationships between functional activation and disability and brain lesion load and atrophy were investigated.Patients showed greater fMRI activation than controls with passive movements in the superior temporal gyrus, rolandic operculum, and putamen. The fMRI response to active and passive movements in the ipsilateral inferior frontal gyrus was lower in patients with greater disability and greater brain T2 lesion load, respectively. Furthermore, the fMRI activation with active movements in the contralateral cerebellum was lower in patients with worse mobility. The increased activity with passive movements in regions that participate in sensori-motor integration, such as the putamen, reflects true functional reorganisation, since passive movements induce brain activation through sensory afferents only. The inverse correlation between the fMRI response in regions that are associated with motor control, and clinical or MRI measures of disease progression, suggests that there is a loss of distributed activation in more disabled patients. This may inform future treatment strategies.

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A functional magnetic resonance imaging study of patients with secondary progressive multiple sclerosis

Cited by 86 publications

References 50 publications

Is a preserved functional reserve a mechanism limiting clinical impairment in pediatric MS patients?

Is a preserved functional reserve a mechanism limiting clinical impairment in pediatric MS patients?

Functional MRI in investigating cognitive impairment in multiple sclerosis

Functional response to active and passive ankle movements with clinical correlations in patients with primary progressive multiple sclerosis

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