A fully-integrated semicircular canal processor for an implantable vestibular prosthesis

Constandinou, Timothy G.; Georgiou, Julius; Toumazou, C.

doi:10.1109/icecs.2008.4674796

Cited by 10 publications

(8 citation statements)

References 13 publications

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“…Phillips et al [14], Shkel et al [15], and Constandinou et al [16;17] have described efforts to develop vestibular prosthesis circuitry. Phillips et al [14] modified a commercially-available cochlear implant for use as a vestibular prosthesis.…”

Section: Introductionmentioning

confidence: 99%

“…Shkel et al [15] described a microelectromechanical system (MEMS) gyro and a circuit meant to emulate normal SCC dynamics described by Baird et al [18]. Constandinou et al [16;17] described an Application Specific Integrated Circuit intended for integration into a vestibular prosthesis. Neither Shkel et al nor Constandinou et al have reported in vivo results.…”

Section: Introductionmentioning

confidence: 99%

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Design and performance of a multichannel vestibular prosthesis that restores semicircular canal sensation in rhesus monkey

Chiang

Fridman

Dai

et al. 2011

IEEE Trans. Neural Syst. Rehabil. Eng.

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In normal individuals, the vestibular labyrinths sense head movement and mediate reflexes that maintain stable gaze and posture. Bilateral loss of vestibular sensation causes chronic disequilibrium, oscillopsia, and postural instability. We describe a new multichannel vestibular prosthesis (MVP) intended to restore modulation of vestibular nerve activity with head rotation. The device comprises motion sensors to measure rotation and gravitoinertial acceleration, a microcontroller to calculate pulse timing, and stimulator units that deliver constant-current pulses to microelectrodes implanted in the labyrinth. This new MVP incorporates many improvements over previous prototypes, including a 50% decrease in implant size, a 50% decrease in power consumption, a new microelectrode array design meant to simplify implantation and reliably achieve selective nerve-electrode coupling, multiple current sources conferring ability to simultaneously stimulate on multiple electrodes, and circuitry for in vivo measurement of electrode impedances. We demonstrate the performance of this device through in vitro bench-top characterization and in vivo physiological experiments with a rhesus macaque monkey.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Design and performance of a multichannel vestibular prosthesis that restores semicircular canal sensation in rhesus monkey

Chiang

Fridman

Dai

et al. 2011

IEEE Trans. Neural Syst. Rehabil. Eng.

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“…For example, when compared with systems using off-the-shelf components and processors [4, 6, 36], the signal processor ASIC has the advantage of energy-efficiency and small footprint without compromising the functionality. Our design advances the other custom design reported in [5, 37, 38] through a coordinate system transformation, which could potentially improve stimulation efficacy [13]. …”

Section: Resultsmentioning

confidence: 99%

A Low-Power ASIC Signal Processor for a Vestibular Prosthesis

Töreyin

Bhatti

2016

IEEE Trans. Biomed. Circuits Syst.

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A low-power ASIC signal processor for a vestibular prosthesis (VP) is reported. Fabricated with TI 0.35 μm CMOS technology and designed to interface with implanted inertial sensors, the digitally assisted analog signal processor operates extensively in the CMOS subthreshold region. During its operation the ASIC encodes head motion signals captured by the inertial sensors as electrical pulses ultimately targeted for in-vivo stimulation of vestibular nerve fibers. To achieve this, the ASIC implements a coordinate system transformation to correct for misalignment between natural sensors and implanted inertial sensors. It also mimics the frequency response characteristics and frequency encoding mappings of angular and linear head motions observed at the peripheral sense organs, semicircular canals and otolith. Overall the design occupies an area of 6.22 mm2 and consumes 1.24 mW when supplied with ± 1.6 V.

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“…4. This has been designed to provide an approximate bandpass transfer in preference to a biomimetic replica [6]. Using an OTA-C realisation, first order low pass (LP) and high pass (HP) stages have been cascaded to realise a bandpass response.…”

Section: B Semicircular Canal Processormentioning

confidence: 99%

A neural implant ASIC for the restoration of balance in individuals with vestibular dysfunction

Constandinou

Georgiou

Toumazou

2009

2009 IEEE International Symposium on Circuits and Systems

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Abstract-This paper describes an ASIC developed as part of a neural prosthesis to restore balance to individuals with a dysfunctional vestibular end-organ. The device interfaces with inertia sensors; sensing acceleration in five degrees of freedom (three radial and two linear axis), and then conditions, processes and converts the signals to provide the artificial stimulus to the vestibulocochlear nerve. The IC described herein has been realised as part of a board-level solution, also including the sensors, power source and DC blocking capacitors. It is envisaged that this can be later implemented in a System-in-Package (SiP) form to provide a totally implantable solution. We describe the design and implementation of the integrated circuit in a standard 0.35μm CMOS technology.

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A fully-integrated semicircular canal processor for an implantable vestibular prosthesis

Cited by 10 publications

References 13 publications

Design and performance of a multichannel vestibular prosthesis that restores semicircular canal sensation in rhesus monkey

Design and performance of a multichannel vestibular prosthesis that restores semicircular canal sensation in rhesus monkey

A Low-Power ASIC Signal Processor for a Vestibular Prosthesis

A neural implant ASIC for the restoration of balance in individuals with vestibular dysfunction

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