A fully integrated fast scan cyclic voltammetry electrochemical method: Improvements in reaction kinetics and signal stability for specific Ag(I) and Hg(II) analysis

Wang, Qi; Zhou, Huiqian; Hao, Tingting; Hu, Kai-Xin; Qin, Lingxia; Ren, Xinxin; Guo, Zhiyong; Wang, Sui; Hu, Yufang

doi:10.1016/j.jelechem.2022.116208

Cited by 7 publications

(3 citation statements)

References 60 publications

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“…The utilization of this technique has demonstrated significant value in the field of neuroscience research, providing valuable insights into fundamental elements of brain functioning regarding addiction and several neurological disorders [ 67 , 68 ]. Moreover, FSCV has been utilized in several fields, such as environmental monitoring, medicinal research, and materials science, wherein the comprehension of fast electrochemical phenomena holds substantial importance [ 69 , 70 ].…”

Section: Recent Advances In Electrochemical Nanobiosensors For Neurot...mentioning

confidence: 99%

An Updated Review on Electrochemical Nanobiosensors for Neurotransmitter Detection

Choi,

Yoon

2023

Biosensors

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Neurotransmitters are chemical compounds released by nerve cells, including neurons, astrocytes, and oligodendrocytes, that play an essential role in the transmission of signals in living organisms, particularly in the central nervous system, and they also perform roles in realizing the function and maintaining the state of each organ in the body. The dysregulation of neurotransmitters can cause neurological disorders. This highlights the significance of precise neurotransmitter monitoring to allow early diagnosis and treatment. This review provides a complete multidisciplinary examination of electrochemical biosensors integrating nanomaterials and nanotechnologies in order to achieve the accurate detection and monitoring of neurotransmitters. We introduce extensively researched neurotransmitters and their respective functions in biological beings. Subsequently, electrochemical biosensors are classified based on methodologies employed for direct detection, encompassing the recently documented cell-based electrochemical monitoring systems. These methods involve the detection of neurotransmitters in neuronal cells in vitro, the identification of neurotransmitters emitted by stem cells, and the in vivo monitoring of neurotransmitters. The incorporation of nanomaterials and nanotechnologies into electrochemical biosensors has the potential to assist in the timely detection and management of neurological disorders. This study provides significant insights for researchers and clinicians regarding precise neurotransmitter monitoring and its implications regarding numerous biological applications.

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Section: Recent Advances In Electrochemical Nanobiosensors For Neurot...mentioning

confidence: 99%

An Updated Review on Electrochemical Nanobiosensors for Neurotransmitter Detection

Choi,

Yoon

2023

Biosensors

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“…Theoretically, the reaction kinetics process is concentration dependent. 34 In order to gain a better understanding of the connection between the DPV response and the concentration of quercetin, we examined the DPV response of quercetin on the Pt/GCE electrode in a Britton−Robinson solution, employing various concentrations of quercetin. As depicted in Figure 3h, the current of the oxidation peak exhibits a gradual increment as the concentration of quercetin rises.…”

Section: Electrochemical Behaviormentioning

confidence: 99%

Insights in Electrochemical Determination of Quercetin in Peach Vinegar by the Hexagonal Platinum Nanocrystal

Zhang,

Peng,

Gao

2023

ACS Omega

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Peach vinegar is a popular condiment that is thought to have various health benefits. However, the low levels of quercetin and complex detection environment in peach vinegar make it difficult to detect using traditional methods. Electrochemical detection is a promising solution because it is sensitive, inexpensive, and provides real-time results. Herein, a hexagonal Pt nanocrystal was developed as an electrocatalyst for selective detection of quercetin in peach vinegar, and a comprehensive examination was given of the electrochemical characteristics of quercetin when applied to electrodes modified with platinum. The morphology and crystal properties of Pt nanocrystals were analyzed, and the Pt-modified electrode was found to exhibit strong electrocatalytic effects toward quercetin in peach vinegar with a high sensitivity of 58 μA μM–1. Furthermore, the investigation showcased exceptional specificity, consistency, sustained durability, and replicability of the Pt-modified electrode in identifying quercetin. The detection result of the Pt-modified electrode tested in three different peach vinegar samples demonstrated its practical utility in real-world applications. Overall, the findings of this study may have important implications for the development of more efficient and sensitive electrochemical sensors for the detection of quercetin and other analytes in vinegar.

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“…23 Herein, TIP60 (60 kDa, KAT5) is employed as a model to develop a novel label-free electrochemical FSCV assay, which leverages the redox properties of Cu(II) within a coenzyme A (CoA)-Cu(II) coordination polymer on a graphene oxide (GO)modified indium−tin oxide electrode (ITO). The detection mechanism incorporates three key innovations: (1) CoA, a byproduct of acetylation, comprising cysteine, pantothenate, and adenosine, 24,25 forms a chain-like (-CoA-Cu(II)−) structure that overcomes the limitations of unamplified enzyme/protein signals; (2) FSCV with ohmic drop compensation, a self-established system (Figure S1) recognized for its ultrafast scanning capabilities as outlined in previous research, 20,26 can rapidly alternate Cu(II) between its reduced (Cu(0)) and oxidized states, maintaining Cu within the nanostructure and preserving signal integrity; the special time−voltage curve is acquired through the current/voltage (I/V) conversion circuit; (3) a mini electrochemical system that requires less than 50 μL of sample has been constructed to optimize space for trace analysis; in this system, the ITO substrate serves dual functions as both the electrochemical cell and electrode, facilitating the miniaturization of the biosensor. This approach enables the precise quantification of TIP60 activity and has implications for investigating acetylation in lung cancer cells.…”

Section: ■ Introductionmentioning

confidence: 99%

Portable Detection of Lysine Acetyltransferase Activity in Lung Cancer Cells Based on a Miniature Electrochemical Sensor

Liu,

Lu,

et al. 2024

Anal. Chem.

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The detection of lysine acetyltransferases is crucial for diagnosing and treating lung cancer, highlighting the necessity for highly efficient detection methods. We developed a portable, highly accurate, and sensitive technique using fast-scan cyclic voltammetry (FSCV) to determine the activity of the lysine acetyltransferase TIP60, employing a novel miniature electrochemical sensor. This approach involves a compact electrochemical cell, merely 3 mm in diameter, that holds solutions up to 50 μL, equipped with a conductive indium tin oxide working electrode. Uniquely, this system operates on a two-electrode model compatible with the FSCV, obviating the traditional requirement for a reference electrode. The system detects TIP60 activity through the continuous generation of CoA molecules that engage in reactions with Cu(II), thereby significantly improving the accuracy of the acetylation analysis. Remarkably, the detection limit achieved for TIP60 is notably low at 3.3 pg/mL (S/N = 3). The results show that the reversible dynamic acetylation can be effectively regulated by inhibitor incubation and glucose stimulation. This cutting-edge strategy enhances the analysis of a broad spectrum of biomarkers by modifying the responsive unit, and its miniaturization and portability significantly amplify its applicability in biomedical research, promising it to be a versatile tool for early diagnostic and therapeutic interventions in lung cancer.

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A fully integrated fast scan cyclic voltammetry electrochemical method: Improvements in reaction kinetics and signal stability for specific Ag(I) and Hg(II) analysis

Cited by 7 publications

References 60 publications

An Updated Review on Electrochemical Nanobiosensors for Neurotransmitter Detection

An Updated Review on Electrochemical Nanobiosensors for Neurotransmitter Detection

Insights in Electrochemical Determination of Quercetin in Peach Vinegar by the Hexagonal Platinum Nanocrystal

Portable Detection of Lysine Acetyltransferase Activity in Lung Cancer Cells Based on a Miniature Electrochemical Sensor

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