A fully-coupled fluid-structure interaction simulation of cerebral aneurysms

Bazilevs, Yuri; Hsu, Ming‐Chen; Zhang, Yongjie; Wang, W.; Liang, Xinghua; Kvamsdal, Trond; Brekken, Reidar; Isaksen, Jørgen Gjernes

doi:10.1007/s00466-009-0421-4

Cited by 217 publications

(108 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This assumption of rigid wall is found in the majority of published studies. While neglecting the compliance of the geometry will have an effect on the velocity and WSS fields [35], it can be expected that the essential features of the flow are similar. For the inlet and outlet, physiologically realistic boundary conditions are obtained using @neufuse (www.…”

Section: Boundary Conditionsmentioning

confidence: 99%

Transitional flow in aneurysms and the computation of haemodynamic parameters

Poelma

Watton

Ventikos

2015

J. R. Soc. Interface.

View full text Add to dashboard Cite

Haemodynamic forces appear to play an influential role in the evolution of aneurysms. This has led to numerous studies, usually based on computational fluid dynamics. Their focus is predominantly on the wall shear stress (WSS) and associated derived parameters, attempting to find correlations between particular patterns of haemodynamic indices and regions subjected to disease formation and progression. The indices are generally determined by integration of flow properties over a single cardiac cycle. In this study, we illustrate that in some cases the transitional flow in aneurysms can lead to significantly different WSS distributions in consecutive cardiac cycles. Accurate determination of time-averaged haemodynamic indices may thus require simulation of a large number of cycles, which contrasts with the common approach to determine parameters using data from a single cycle. To demonstrate the role of transitional flow, two exemplary cases are considered: flow in an abdominal aortic aneurysm and in an intracranial aneurysm. The key differences that are observed between these cases are explained in terms of the integral timescale of the transitional flows in comparison with the cardiac cycle duration: for relatively small geometries, transients will decay before the next cardiac cycle. In larger geometries, transients are still present when the systolic phase produces new instabilities. These residual fluctuations serve as random initial conditions and thus seed different flow patterns in each cycle. To judge whether statistics are converged, the derived indices from at least two successive cardiac cycles should be compared.

show abstract

Section: Boundary Conditionsmentioning

confidence: 99%

Transitional flow in aneurysms and the computation of haemodynamic parameters

Poelma

Watton

Ventikos

2015

J. R. Soc. Interface.

View full text Add to dashboard Cite

show abstract

“…This article addresses one of these shortcoming by introducing flexible wall modeling in Fontan surgery simulations. Including arterial fluid-structure interaction (FSI) has been found to be important for modeling other parts of the cardiovascular system (see, e.g., [5,46,47,51]), and the Fontan surgery, as will be shown in this article, presents no exception. It should be noted that an idealized Fontan configuration without pulmonary branching was studied using flow-structure interaction in [27].…”

mentioning

confidence: 99%

Computational fluid–structure interaction: methods and application to a total cavopulmonary connection

et al. 2009

Self Cite

View full text Add to dashboard Cite

The Fontan procedure is a surgery that is performed on single-ventricle heart patients, and, due to the wide range of anatomies and variations among patients, lends itself nicely to study by advanced numerical methods. We focus on a patient-specific Fontan configuration, and perform a fully coupled fluid-structure interaction (FSI) analysis of hemodynamics and vessel wall motion. To enable physiologically realistic simulations, a simple approach to constructing a variable-thickness blood vessel wall description is proposed. Rest and exercise conditions are simulated and rigid versus flexible vessel wall simulation results are compared. We conclude that flexible wall modeling plays an important role in predicting quantities of hemodynamic interest in the Fontan connection. To the best of our knowledge, this paper presents the first three-dimensional patientspecific fully coupled FSI analysis of a total cavopulmonary connection that also includes large portions of the pulmonary circulation.

show abstract

“…A lot of attention has gone to biomedical applications in the FSI community because of the many interactions taking place in the human body. FSI simulations of the blood flow running through large, elastic arteries and the interaction with heart valves [17,86,153,223,243,283] can be used to predict ruptures of aneurysms [19,246,248] or to improve the design of artificial heart valves and stents [9,70,263]. Also applications for the respiratory system are developed with FSI, e.g.…”

Section: Numerical Modelsmentioning

confidence: 99%

“…The integral length scale L x u ′ e.g. is a measure for the longitudinal (x-direction) size of the vortices associated with the longitudinal velocity fluctuations u ′ (x, t) and is defined as [229]: 19) where…”

Section: Atmospheric Turbulencementioning

confidence: 99%