A fructan from Anemarrhena asphodeloides Bunge showing neuroprotective and immunoregulatory effects

The central nervous system (CNS) regulates and coordinates an extensive array of complex processes requiring harmonious regulation of specific genes. CNS disorders represent a large burden on society and cause enormous disability and economic losses. Traditional Chinese medicine (TCM) has been used for many years in the treatment of neurological illnesses, such as Alzheimer's disease, Parkinson's disease, stroke, and depression, as the combination of TCM and Western medicine has superior therapeutic efficacy and minimal toxic side effects. Mangiferin (MGF) is an active compound of the traditional Chinese herb rhizome anemarrhenae, which has antioxidant, anti-inflammation, anti-lipid peroxidation, immunomodulatory, and antiapoptotic functions in the CNS. MGF has been demonstrated to have therapeutic effects in CNS diseases through a multitude of mechanisms. This review outlines the latest research on the neuroprotective ability of MGF and the diverse molecular mechanisms involved.

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“…Much work has focused on exploring whether TCM promotes neural regeneration (Zhang, Shen, & So, 2014;Zhang et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective mechanisms of mangiferin in neurodegenerative diseases

Liu

Song

2021

Drug Development Research

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“…According to its retention time on the HPGPC system, the M w of AABP-2B was determined to be 5800 Da, which was different from the reported polysaccharides isolated from Anemarrhena asphodeloides Bunge (AAP70-1). 7 The different molecular weight distributions indicated significant differences between polysaccharides, indicating that AABP-2B was a novel polysaccharide from Anemarrhena asphodeloides Bunge. 16 HPLC was applied to analyse the monosaccharide composition of AABP-2B.…”

Section: Physicochemical Property Analysismentioning

confidence: 96%

“…5,6 Polysaccharides, one of the main active ingredients of Anemarrhena asphodeloides Bunge, exhibit various pharmacological effects, such as antioxidant, neuroprotective, and hypoglycaemic effects. 7,8 A novel polysaccharide containing glucose and fructose was isolated from Anemarrhena asphodeloides Bunge (A. asphodeloides), and this polysaccharide possesses strong neuroprotective and immunomodulatory effects. 7 Four glycans (anamerans A, B, C and D) and crude polysaccharides isolated from Anemarrhenae rhizoma display excellent hypoglycaemic activity, reducing blood glucose levels in STZ-induced diabetic rats.…”

Section: Introductionmentioning

confidence: 99%

“…7,8 A novel polysaccharide containing glucose and fructose was isolated from Anemarrhena asphodeloides Bunge (A. asphodeloides), and this polysaccharide possesses strong neuroprotective and immunomodulatory effects. 7 Four glycans (anamerans A, B, C and D) and crude polysaccharides isolated from Anemarrhenae rhizoma display excellent hypoglycaemic activity, reducing blood glucose levels in STZ-induced diabetic rats. 9,10 However, to date, little information is available on the structure and potential hypoglycaemic mechanisms of polysaccharides from A. asphodeloides.…”

Section: Introductionmentioning

confidence: 99%

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Structural characterization and in vitro hypoglycaemic activity of glucomannan from Anemarrhena asphodeloides Bunge

et al. 2022

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“…A structural analysis revealed that it is a branched polysaccharide with a molecular weight of 2.72 kDa. The treatment of RAW264.7 cells with AAP70-1 promoted phagocytic activity and the secretion of proinflammatory cytokines [ 158 ].…”

Section: Natural Products That Enhance Immunitymentioning

confidence: 99%

Development of Broad-Spectrum Antiviral Agents—Inspiration from Immunomodulatory Natural Products

Zhang

Xiong

Song

et al. 2021

Viruses

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Developing broad-spectrum antiviral drugs remains an important issue as viral infections continue to threaten public health. Host-directed therapy is a method that focuses on potential targets in host cells or the body, instead of viral proteins. Its antiviral effects are achieved by disturbing the life cycles of pathogens or modulating immunity. In this review, we focus on the development of broad-spectrum antiviral drugs that enhance the immune response. Some natural products present antiviral effects mediated by enhancing immunity, and their structures and mechanisms are summarized here. Natural products with immunomodulatory effects are also discussed, although their antiviral effects remain unknown. Given the power of immunity and the feasibility of host-directed therapy, we argue that both of these categories of natural products provide clues that may be beneficial for the discovery of broad-spectrum antiviral drugs.

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A fructan from Anemarrhena asphodeloides Bunge showing neuroprotective and immunoregulatory effects

Cited by 61 publications

References 75 publications

Neuroprotective mechanisms of mangiferin in neurodegenerative diseases

Neuroprotective mechanisms of mangiferin in neurodegenerative diseases

Structural characterization and in vitro hypoglycaemic activity of glucomannan from Anemarrhena asphodeloides Bunge

Development of Broad-Spectrum Antiviral Agents—Inspiration from Immunomodulatory Natural Products

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