Abstract-Multiple-patterning optical lithography is inevitable for technology scaling beyond the 22nm technology node. Multiple patterning imposes several counter-intuitive restrictions on layout and carries serious challenges for design methodology. This paper examines the role of design at different stages of the development and adoption of multiple patterning: technology development, design enablement, and process control. We discuss how explicit design involvement can enable timely adoption of multi-patterning with reduced costs both in design and manufacturing.