A four-year observation of HIV and sexually transmitted infections among men who have sex with men before and during pre-exposure prophylaxis in Tokyo

Mizushima, Daisuke; Takano, Misao; Ando, Naokatsu; Uemura, Haruka; Yanagawa, Yasuaki; Aoki, Takeshi; Watanabe, Kôji; Ishizuka, Naoki; Oka, Shinichi

doi:10.1016/j.jiac.2022.02.013

Cited by 10 publications

(13 citation statements)

References 21 publications

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“…We previously reported that, in a feasibility study in Tokyo, the adherence to PrEP was as high as 95%. [23] The reason for this high adherence rate is possibly attributable to the limited access to PrEP and increased awareness of PrEP among MSM in Japan. As of March 2022, PrEP had not been approved in Japan and there was no public provision for PrEP.…”

Section: Discussionmentioning

confidence: 99%

Effect of tenofovir-based HIV pre-exposure prophylaxis against HBV infection in men who have sex with men

et al. 2023

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Background and Aims: Men who have sex with men (MSM) are vulnerable to contracting HBV as a sexually transmitted infection. We evaluated the incidence of HBV infection (HBI) and the prophylactic effect of tenofovir-based pre-exposure prophylaxis (PrEP) on HBI in an MSM cohort. Methods and Results: MSM who were older than 16 years were enrolled from January 2018 and followed up until June 2021 and tested for HIV, bacterial sexually transmitted infections, and HBsAg/ HBsAb and HBcAb every 3 months based on inclusion criteria, including HBsAg, HBcAb, HBsAb, and HIV negativity at enrollment. HBI was defined as seroconversion of HBsAg or HBcAb status. The log-rank test was used to evaluate the prophylactic effect of PrEP against HBI. As a substudy, individuals excluded from the main study due to HBs Ab positivity were evaluated for HBI incidence. Among 1577 MSM, 786 participants (546 PrEP nonusers, 131 daily PrEP users, and 109 event-driven PrEP users) met the criteria and were included. The annual incidence of HBV among PrEP nonusers (3.8%, 21 infections, with 559.5 person-years) was significantly higher (p = 0.018, log-rank test) than that among daily PrEP users [0.77%, 1 infection (admitted nonadherence), with 129.3 person-years] and event-driven PrEP users (no infection with 93.8 person-years). Although the incidence of HBI and HIV infection decreased with PrEP use, the incidence of other sexually transmitted infections was higher in both daily and event-driven PrEP users. The annual incidence of HBV among HBsAb-positive and HBcAb-negative PrEP nonusers was 1.8% (3 infections, with 167.5 person-years). Conclusions: Tenofovir-based PrEP prevented HBI among MSM in a real-world setting.

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Section: Discussionmentioning

confidence: 99%

Effect of tenofovir-based HIV pre-exposure prophylaxis against HBV infection in men who have sex with men

et al. 2023

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“…Data from prior epidemic areas show that it is particularly common among MSM who are PWH and users of pre-exposure prophylaxis against HIV, who may be more likely to be diagnosed with mpox because they have better access to medical services that can manage mpox [ 3 , 4 ]. Hence, as with other STDs common among Japanese MSM [ 5 ], there are probably many undiagnosed cases of mpox, however reports examining the extent to which mpox is underdiagnosed in Western countries are scarce. On the other hand, it has been suggested that there may be many undiagnosed cases in Asian countries, where the incidence is currently low, due to a lack of diagnostic resources [ 6 , 7 ].…”

Section: Discussionmentioning

confidence: 99%

Mpox associated with Panton-Valentin leucocidin-producing methicillin-resistant Staphylococcus aureus among people with HIV

Adachi

Ikeuchi

Otani

et al. 2023

Journal of Infection and Chemotherapy

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“…Not only for HCV, but likewise for all STDs, sexually active MSM are at the same increased risk of STDs regardless of whether or not they are PWH, and are likely to remain undiagnosed 8,9 . HIV postexposure prophylaxis (PrEP) is becoming more widespread worldwide, and the number of HIV‐PrEP users is increasing in Japan 10 . Increasing opportunities for hospital visits and testing for STDs would lead to the uncovering of undiagnosed STDs 9–11 .…”

Section: Total Group 1 (2009–2019) Group 2 (2019–2023) P Valuementioning

confidence: 99%

“…8,9 HIV postexposure prophylaxis (PrEP) is becoming more widespread worldwide, and the number of HIV-PrEP users is increasing in Japan. 10 Increasing opportunities for hospital visits and testing for STDs would lead to the uncovering of undiagnosed STDs. [9][10][11] Therefore, physicians need to be made widely aware of the need to consider HCV as an STD.…”

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confidence: 99%

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Incidence of sexually transmitted hepatitis C virus infection among men who have sex with men in Japan from 2009 to 2023

Adachi,

Saito,

Kikuchi

et al. 2023

Journal of Medical Virology

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Although the prevalence of hepatitis C virus (HCV) infection has decreased significantly with the advent of direct‐acting antiviral agents, HCV is known to spread as a sexually transmitted disease among men who have sex with men (MSM), and this study aims to provide a perspective on the future prevalence of HCV in Japan. We examined incidence in two groups of MSM with HIV attending our institution in this retrospective cohort study, from 2009 to 2019 and from 2020 to May 2023 and investigated their background factors. Twenty‐two cases were newly confirmed to be HCV infection in 2009–2019 and a total of 9 cases in 2020–2023, with an incidence rate of 5.04 per 1000 person‐years in 2009–2019 and 5.55 per 1000 person‐years in 2020–2023. All of them were diagnosed at routine outpatient visits for HIV, and few cases were considered to have symptoms of suspected hepatitis that led to a visit to the hospital and a diagnosis of HCV. Although HCV is still prevalent among MSM in Japan, it is possible that it would not have been diagnosed without testing at regular visits as in the case of people with HIV, and that the true prevalence rate among MSM, including non‐HIV‐infected persons, may be much higher.

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A four-year observation of HIV and sexually transmitted infections among men who have sex with men before and during pre-exposure prophylaxis in Tokyo

Cited by 10 publications

References 21 publications

Effect of tenofovir-based HIV pre-exposure prophylaxis against HBV infection in men who have sex with men

Effect of tenofovir-based HIV pre-exposure prophylaxis against HBV infection in men who have sex with men

Mpox associated with Panton-Valentin leucocidin-producing methicillin-resistant Staphylococcus aureus among people with HIV

Incidence of sexually transmitted hepatitis C virus infection among men who have sex with men in Japan from 2009 to 2023

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