A follow-up study of nutrient intake, nutritional status, and growth in infants with cow milk allergy fed either a soy formula or an extensively hydrolyzed whey formula

Abstract

Both nutritional status and growth were well within reference values in the 2 groups, and the selection of a formula can largely be made on the basis of infant tolerance to the formulas.

Soy‐Based Infant Formula Supplemented with DHA and ARA Supports Growth and Increases Circulating Levels of these Fatty Acids in Infants

“…Rates of study discontinuation and adverse events were similar between formula groups and incidence of serious adverse events was low and deemed unrelated to the study products by participating physicians. Previous clinical evidence also indicates infant tolerance of soy-based formulas, with favorable comparison to cow's milk-based formula [22,30,31]. Our study demonstrated that the soy-based control formula and soy-based formula supplemented with DHA and ARA were equally well tolerated by infants, with very low incidence of allergic manifestations.…”

An antibody response to cholera toxin, but not soy proteins, following oral administration of adjuvanted soybean formulations

“…Such oral formulations would likely contain a mucosal adjuvant (Freytag & Clements, 2005), which raises the important consideration of immune responses developing against soy proteins. The safety of soy proteins in foodstuffs is well documented (Messina, 1999;Motil, 2000;Seppo et al, 2005;Slavin, 1991) with only a small percentage of the population having food allergies against this agricultural product (Cordle, 2004;Friedman & Brandon, 2001). In fact, soy milk formulations are so safe that they are routinely fed to infants (Badger, Ronis, Hakkak, Rowlands, & Korourian, 2002).…”

“…However, most human diets (Messina, 1999;Motil, 2000;Seppo et al, 2005;Slavin, 1991), and many standard laboratory rodent chows, contain significant amounts of soy protein. One previous study suggested that mice fed normal diets did not mount a specific IgE response against soy proteins given intragastrically with pertussis toxin (Bozelka et al, 1987).…”

“…When formulating these immunogens into oral vaccines, it was not altogether clear whether it would be necessary to purify the transgenic proteins from seeds prior to use, or whether seed preparations containing normal soy proteins might also be innocuous if present in vaccines. Soy protein is present in the diets of most individuals (Messina, 1999;Motil, 2000;Seppo et al, 2005;Slavin, 1991), and only a small percentage have adverse reactions following consumption of soy proteins (Cordle, 2004;Friedman & Brandon, 2001). Soy protein is also a staple in livestock feeds (Friedman & Brandon, 2001).…”

Processing Foods Free from Dairy Proteins

“…In another study, Moughan et al [185] reported that it is unlikely that replacement of milk protein with soy -based formulae will cause any major differences in the digestive process. Seppo et al [186] compared nutrient intake, nutritional status, and growth of cow ' s milk -allergic infants fed with soy formulae and extensively hydrolyzed whey formulae from cow ' s milk supplemented with vitamin D and calcium for 2 years. The study revealed no signifi cant difference in the growth (% weight for length) of infants consuming soy formulae and whey -hydrolyzed formulae during the 2 years.…”