A follow-up study of children born after intracytoplasmic sperm injection (ICSI) with epididymal and testicular spermatozoa and after replacement of cryopreserved embryos obtained after ICSI

Bonduelle, M; Wilikens, Ann; Buysse, Andrea; Assche, Elvire Van; Devroey, Paul; Steirteghem, A.C. Van; Liebaers, Ingeborg

doi:10.1093/humrep/13.suppl_1.196

Cited by 81 publications

(26 citation statements)

References 34 publications

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“…Earlier studies did not fi nd a rise in the malformation rate after ICSI [10,11,30,38,40] . However, the number of cases was either very low or there was no control group or the investigation technique was not performed in a standard fashion.…”

Section: Fetal Malformations After Artmentioning

confidence: 84%

Perinatal risks after IVF and ICSI

Zollner

Dietl

2012

Journal of Perinatal Medicine

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Pregnancies that occur after infertility treatment, particularly after assisted reproduction, constitute high-risk pregnancies. Occurrences of conditions such as high blood pressure, preeclampsia, growth retardations and bleeding are higher in comparison with the norm of spontaneously entered pregnancies. The rate of premature births and the frequency of intrauterine deaths are much higher than the average for all pregnancies. Furthermore, pregnancies resulting from in -vitro fertilisation (IVF) have signifi cantly higher rates of requiring induced labour or caesarean section. However, it is to be assumed that these complications and unfortunate developments are not caused by extracorporeal fertilisation itself, but rather are due to the frequency of multiples and to the risk factors of the women involved. These women are, on average, older and there are often more problems with cycle irregularities, uterine anomalies and obesity than in the total collective of all pregnancies. The methods of modern reproductive medicine often bring a higher rate of multiple pregnancies. The clinical problem of multiple pregnancies is, above all, the raised rate of premature births and intrauterine growth retardations that contribute to the signifi cantly higher rate of morbidity and mortality for these children. The slightly higher rate of congenital defects after IVF and intracytoplasmic sperm injection (ICSI) are also attributed more to the risk profi le of the parents and less to the techniques themselves. The most important and easy-to-avoid complication is the multiple pregnancy, and it should be our goal to lower this rate even further.

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Section: Fetal Malformations After Artmentioning

confidence: 84%

Perinatal risks after IVF and ICSI

Zollner

Dietl

2012

Journal of Perinatal Medicine

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“…Several studies have demonstrated that there is no increase in the incidence of congenital anomalies in children born after ICSI compared with standard IVF or with the general population [29][30][31][32][33][34][35][36]. However, others showed that infants born after ICSI might indeed have an excess of major birth defects [37][38][39] and an increased incidence of chromosomal abnormalities [31,35]. It is possible that the increases in congenital abnormalities observed in some ICSI children, such as hypospadias or sex chromosome abnormalities, are due to factors related to paternal infertility and the use of suboptimal male gametes.…”

Section: Discussionmentioning

confidence: 99%

Comparison of embryo quality between intracytoplasmic sperm injection and in vitro fertilization in sibling oocytes

Yoeli

Orvieto

Ashkenazi

et al. 2008

J Assist Reprod Genet

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Background The aim of the present study was to compare the quality of embryos derived from sibling oocytes by in vitro fertilization (IVF) or ICSI. Methods Consecutive patients with a less than 40% fertilization rate in a previous standard IVF cycle or with relative male factor infertility were recruited for the study. The oocytes retrieved from each patient were divided into two groups for either conventional insemination (group A) or ICSI (group B). Power analysis showed that to detect a 25% difference in the rate of high-quality embryos between the groups with a power of 0.8, at least 1,200 oocytes were needed in each group. Results One hundred seventy-seven patients were included in the study. Group A was comprised of 1,526 oocytes and group B of 1,480 sibling oocytes. As expected, the fertilization rate was significantly higher in group B than group A (67.1 vs. 43.6%, p < 0.001). No significant between-group differences were observed in cleavage rate (92.7 and 89.7%, respectively) and the rate of either grade A embryos (22.6 and 23.9%, respectively) or grade A 1 embryos (37.3 and 33.5%, respectively).However, in the subgroup of patients with relative malefactor infertility (n=36), the rate of grade A 1 embryos was significantly higher in the IVF than the ICSI group (46.4 vs. 29.0%, respectively, p=0.02). Conclusions Embryo quality does not seem to be influenced by the mode of fertilization (IVF or ICSI). We assume that embryo quality depends on intrinsic factors of the gametes involved rather than on the fertilization process per se.

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“…32 Bonduelle and colleagues 33 found that the sex ratio of children born after intracytoplasmic sperm injection (ICSI) with testicular or epididymal spermatozoa was modified to 0·40 and 0·60, for males and females, respectively. Additional data from Bonduelle (personal communication) show a significant difference (p=0·05).…”

Section: Discussionmentioning

confidence: 99%

Paternal concentrations of dioxin and sex ratio of offspring

et al. 2000

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SummaryBackground 2, 3,7,, is commonly considered the most toxic man-made substance. We have previously shown that high serum concentrations of TCDD in parents from Seveso, Italy, were linked to their having a relative increase in the number of female births after the parents exposure to a release of dioxin in 1976. We have continued the study to determine whether the parents' sex and/or age at exposure affected the sex ratio of their children. MethodsWe measured the TCDD concentrations in serum samples from potentially exposed parents collected in 1976 and 1977, and investigated the sex ratio of their offspring.Findings Serum samples were collected from 239 men and 296 women. 346 girls and 328 boys were born to potentially exposed parents between 1977 and 1996, showing an increased probability of female births (lower sex ratio) with increasing TCDD concentrations in the serum samples from the fathers (p=0·008). This effect starts at concentrations less than 20 ng per kg bodyweight. Fathers exposed when they were younger than 19 years of age sired significantly more girls than boys (sex ratio 0·38 [95% CI 0·30-0·47]).Interpretation Exposure of men to TCDD is linked to a lowered male/female sex ratio in their offspring, which may persist for years after exposure. The median concentration of dioxin in fathers in this study is similar to doses that induce epididymal impairments in rats and is about 20 times the estimated average concentration of TCDD currently found in human beings in industrialised countries. These observations could have important public-health implications.

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A follow-up study of children born after intracytoplasmic sperm injection (ICSI) with epididymal and testicular spermatozoa and after replacement of cryopreserved embryos obtained after ICSI

Cited by 81 publications

References 34 publications

Perinatal risks after IVF and ICSI

Perinatal risks after IVF and ICSI

Comparison of embryo quality between intracytoplasmic sperm injection and in vitro fertilization in sibling oocytes

Paternal concentrations of dioxin and sex ratio of offspring

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