A Focused Update on Tardive Dyskinesia

Blanchet, Pierre J.

doi:10.1017/cjn.2020.131

Cited by 2 publications

(2 citation statements)

References 75 publications

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“…These include diabetes mellitus, smoking, substance abuse including alcohol and cocaine, and anticholinergic co‐treatment 272 . Two novel vesicular monoamine transporter type 2 (VMAT2) function inhibitors, valbenazine and deutetrabenazine, have been approved in the US as add‐on therapy for persons with tardive dyskinesia 273 . VMAT2 inhibitors may be used to address tardive dyskinesia‐associated impairments and impact on psychosocial functioning 274 .…”

Section: Schizophreniamentioning

confidence: 99%

Mental health care for older adults: recent advances and new directions in clinical practice and research

et al. 2022

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The world's population is aging, bringing about an ever‐greater burden of mental disorders in older adults. Given multimorbidities, the mental health care of these people and their family caregivers is labor‐intensive. At the same time, ageism is a big problem for older people, with and without mental disorders. Positive elements of aging, such as resilience, wisdom and prosocial behaviors, need to be highlighted and promoted, both to combat stigma and to help protect and improve mental health in older adults. The positive psychiatry of aging is not an oxymoron, but a scientific construct strongly informed by research evidence. We champion a broader concept of geriatric psychiatry – one that encompasses health as well as illness. In the present paper, we address these issues in the context of four disorders that are the greatest source of years lived with disability: neurocognitive disorders, major depression, schizophrenia, and substance use disorders. We emphasize the need for implementation of multidisciplinary team care, with comprehensive assessment, clinical management, intensive outreach, and coordination of mental, physical and social health services. We also underscore the need for further research into moderators and mediators of treatment response variability. Because optimal care of older adults with mental disorders is both patient‐focused and family‐centered, we call for further research into enhancing the well‐being of family caregivers. To optimize both the safety and efficacy of pharmacotherapy, further attention to metabolic, cardiovascular and neurological tolerability is much needed, together with further development and testing of medications that reduce the risk for suicide. At the same time, we also address positive aging and normal cognitive aging, both as an antidote to ageism and as a catalyst for change in the way we think about aging per se and late‐life mental disorders more specifically. It is in this context that we provide directions for future clinical care and research.

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Section: Schizophreniamentioning

confidence: 99%

Mental health care for older adults: recent advances and new directions in clinical practice and research

et al. 2022

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“…The term “classic tardive dyskinesia” represents oro-bucco-lingual stereotypic movements [ 78 ]. Among the most common risk factors for tardive dyskinesia is long-term exposure to high-level dosages of antipsychotic drugs [ 79 ]. Other predisposing factors include African American ethnicity, older age, diabetes mellitus, and the co-occurrence of dystonia or parkinsonism [ 80 ].…”

Section: Tardive Syndromes and Dyskinesiasmentioning

confidence: 99%

Overview of Movement Disorders Secondary to Drugs

Rissardo,

Vora,

Mathew

et al. 2023

Clinics and Practice

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Drug-induced movement disorders affect a significant percentage of individuals, and they are commonly overlooked and underdiagnosed in clinical practice. Many comorbidities can affect these individuals, making the diagnosis even more challenging. Several variables, including genetics, environmental factors, and aging, can play a role in the pathophysiology of these conditions. The Diagnostic and Statistical Manual of Mental Disorders (DSM) and the International Statistical Classification of Diseases and Related Health Problems (ICD) are the most commonly used classification systems in categorizing drug-induced movement disorders. This literature review aims to describe the abnormal movements associated with some medications and illicit drugs. Myoclonus is probably the most poorly described movement disorder, in which most of the reports do not describe electrodiagnostic studies. Therefore, the information available is insufficient for the diagnosis of the neuroanatomical source of myoclonus. Drug-induced parkinsonism is rarely adequately evaluated but should be assessed with radiotracers when these techniques are available. Tardive dyskinesias and dyskinesias encompass various abnormal movements, including chorea, athetosis, and ballism. Some authors include a temporal relationship to define tardive syndromes for other movement disorders, such as dystonia, tremor, and ataxia. Antiseizure medications and antipsychotics are among the most thoroughly described drug classes associated with movement disorders.

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A Focused Update on Tardive Dyskinesia

Cited by 2 publications

References 75 publications

Mental health care for older adults: recent advances and new directions in clinical practice and research

Mental health care for older adults: recent advances and new directions in clinical practice and research

Overview of Movement Disorders Secondary to Drugs

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