A focused review on three-dimensional bioprinting technology for artificial organ fabrication

Panda, Sudhansu Sekhar; Hajra, Sugato; Mistewicz, Krystian; Nowacki, Bartłomiej; In-na, Pichaya; Krushynska, Anastasiia O.; Mishra, Yogendra Kumar; Kim, Hoe Joon

doi:10.1039/d2bm00797e

Cited by 33 publications

(33 citation statements)

References 194 publications

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“…Repairing the cartilage defects in the rabbit model by aligned PLLA-polydopamine chondroitin sulfate fibers was facilitated, and cartilage defects were regenerated by hyaline cartilage-like tissue [89]. In light of the foregoing, the application of nanoscaffolds for cartilage restoration is an auspicious approach with a high application potential, which can gain from recent breakthroughs in biomedical engineering [90][91][92][93].…”

Section: The Effect Of Architectural Features Of Scaffolds On Cartila...mentioning

confidence: 99%

Nanofiber scaffolds based on extracellular matrix for articular cartilage engineering: A perspective

Ahmadian¹,

Eftekhari²,

Janas³

et al. 2023

Nanotheranostics

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Articular cartilage has a low self-repair capacity due to the lack of vessels and nerves. In recent times, nanofiber scaffolds have been widely used for this purpose. The optimum nanofiber scaffold should stimulate new tissue's growth and mimic the articular cartilage nature. Furthermore, the characteristics of the scaffold should match those of the cellular matrix components of the native tissue to best merge with the target tissue. Therefore, selective modification of prefabricated scaffolds based on the structure of the repaired tissues is commonly conducted to promote restoring the tissue. A thorough analysis is required to find out the architectural features of scaffolds that are essential to make the treatment successful. The current review aims to target this challenge. The article highlights different optimization approaches of nanofibrous scaffolds for improved cartilage tissue engineering. In this context, the influence of the architecture of nanoscaffolds on performance is discussed in detail. Finally, based on the gathered information, a future outlook is provided to catalyze development in this promising field.

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Section: The Effect Of Architectural Features Of Scaffolds On Cartila...mentioning

confidence: 99%

Nanofiber scaffolds based on extracellular matrix for articular cartilage engineering: A perspective

Ahmadian¹,

Eftekhari²,

Janas³

et al. 2023

Nanotheranostics

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“…However, the same strategy is not suitable for different formulations. The use of a 3D cancer model instead of an animal model is also an emerging field that could be used for siRNA treatment efficacy [ 230 , 231 ]. The efficacy of RNA therapeutics also depends on the formulation strategies and disease of interest.…”

Section: Future Perspectivesmentioning

confidence: 99%

Oral delivery of RNAi for cancer therapy

Afrin

Bai

Kumar

et al. 2023

Cancer Metastasis Rev

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Cancer is a major health concern worldwide and is still in a continuous surge of seeking for effective treatments. Since the discovery of RNAi and their mechanism of action, it has shown promises in targeted therapy for various diseases including cancer. The ability of RNAi to selectively silence the carcinogenic gene makes them ideal as cancer therapeutics. Oral delivery is the ideal route of administration of drug administration because of its patients’ compliance and convenience. However, orally administered RNAi, for instance, siRNA, must cross various extracellular and intracellular biological barriers before it reaches the site of action. It is very challenging and important to keep the siRNA stable until they reach to the targeted site. Harsh pH, thick mucus layer, and nuclease enzyme prevent siRNA to diffuse through the intestinal wall and thereby induce a therapeutic effect. After entering the cell, siRNA is subjected to lysosomal degradation. Over the years, various approaches have been taken into consideration to overcome these challenges for oral RNAi delivery. Therefore, understanding the challenges and recent development is crucial to offer a novel and advanced approach for oral RNAi delivery. Herein, we have summarized the delivery strategies for oral delivery RNAi and recent advancement towards the preclinical stages.

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“…Currently available bioprinting methods can be categorized as extrusion-based [ 16 ], jetting-based (or droplet-based) [ 17 ], and vat photopolymerization-based (or light-based bioprinting) [ 18 ], according to ASTM standards. The basic principles, along with their advantages and limitations, have been published elsewhere [ 16 , 19 , 20 ]. Since the advent of 3D bioprinting, it has become extensively explored as a promising method to create functional organs or tissues because it allows to fabrication of precisely controlled functional organs, which have been desperately needed for end-stage treatment of diseased organs [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Biocompatibility of Functional Bioinks for 3D Bioprinting

Kim

2023

Bioengineering

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Three-dimensional (3D) bioprinting with suitable bioinks has become a critical tool for fabricating 3D biomimetic complex structures mimicking physiological functions. While enormous efforts have been devoted to developing functional bioinks for 3D bioprinting, widely accepted bioinks have not yet been developed because they have to fulfill stringent requirements such as biocompatibility and printability simultaneously. To further advance our knowledge of the biocompatibility of bioinks, this review presents the evolving concept of the biocompatibility of bioinks and standardization efforts for biocompatibility characterization. This work also briefly reviews recent methodological advances in image analyses to characterize the biocompatibility of bioinks with regard to cell viability and cell-material interactions within 3D constructs. Finally, this review highlights a number of updated contemporary characterization technologies and future perspectives to further advance our understanding of the biocompatibility of functional bioinks for successful 3D bioprinting.

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A focused review on three-dimensional bioprinting technology for artificial organ fabrication

Abstract: Three-dimensional (3D) bioprinting technology has put forward a great deal of interest in the current time by facilitating easy adaptability in many industries and research sectors such as biomedical, manufacturing,...

Cited by 33 publications

References 194 publications

Nanofiber scaffolds based on extracellular matrix for articular cartilage engineering: A perspective

Nanofiber scaffolds based on extracellular matrix for articular cartilage engineering: A perspective

Oral delivery of RNAi for cancer therapy

Characterization of Biocompatibility of Functional Bioinks for 3D Bioprinting

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