A fluorometric and colorimetric dual-mode sensor based on nitrogen and iron co-doped graphene quantum dots for detection of ferric ions in biological fluids and cellular imaging

Gao, Xue; Zhou, Xi; Feng, Yongjin; Wang, Chun Peng; Chu, Fu Xiang

doi:10.1039/c8nj01805g

Cited by 35 publications

(23 citation statements)

References 40 publications

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“…Hydrothermal method is a simple and rapid method for preparing GQDs [47][48][49][50]. GQDs can be finally obtained using a variety of macromolecular or small molecular substances [51] as the starting materials through high temperature and pressure [52][53][54][55]. The principle is to break the bonds between carbon materials to form GQDs via high temperature under high pressure [56][57][58][59].…”

Section: Hydrothermal Methodsmentioning

confidence: 99%

Synthesis of graphene quantum dots and their applications in drug delivery

et al. 2020

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This review focuses on the recent advances in the synthesis of graphene quantum dots (GQDs) and their applications in drug delivery. To give a brief understanding about the preparation of GQDs, recent advances in methods of GQDs synthesis are first presented. Afterwards, various drug delivery-release modes of GQDs-based drug delivery systems such as EPR-pH delivery-release mode, ligand-pH delivery-release mode, EPR-Photothermal delivery-Release mode, and Core/Shell-photothermal/magnetic thermal delivery-release mode are reviewed. Finally, the current challenges and the prospective application of GQDs in drug delivery are discussed.

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Section: Hydrothermal Methodsmentioning

confidence: 99%

Synthesis of graphene quantum dots and their applications in drug delivery

et al. 2020

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“…Moreover, the pH-dependent fluorescence emission of these GQDs also allowed the ratiometric detection of healthy (HEK-293 cell) and tumor cells (HeLa and MCF-7 cell). Similarly, heteroatom co-doped GQDs such as P,N and Fe,N co-doped GQDs were also demonstrated for cellular imaging by different research groups (Ananthanarayanan et al, 2015;Gao et al, 2018). Besides in vitro cellular imaging, Wang's group developed red fluorescent GQDs and demonstrated NIR-I in vivo imaging (Ge et al, 2014).…”

Section: Fluorescence Imagingmentioning

confidence: 99%

Recent Advances on Graphene Quantum Dots for Bioimaging Applications

et al. 2020

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Being a zero-dimensional (0D) nanomaterial of the carbon family, graphene quantum dots (GQDs) showed promising biomedical applications owing to their ultra-small size, non-toxicity, biocompatibility, excellent photo stability, tunable fluorescence, and water solubility, etc., thus capturing a considerable attention in biomedical field. This review summarizes the recent advances made in the research field of GQDs and place special emphasis on their bioimaging applications. We briefly introduce the synthesis strategies of GQDs, including top-down and bottom-up strategies. The bioimaging applications of GQDs are also discussed in detail, including optical [fluorescence (FL)], two-photon FL, magnetic resonance imaging (MRI), and dual-modal imaging. In the end, the challenges and future prospects to advance the clinical bioimaging applications of GQDs have also been addressed.

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“…When using the colorimetric method, a remarkable increase in absorbance peak (color changes) was observed with increasing Fe 3+ concentrations up to 450 μM. The detection limit was 1340 nM [42].…”

Section: Incorporation Of Graphene Quantum Dots With Optical Sensomentioning

confidence: 99%

Development of Graphene Quantum Dots-Based Optical Sensor for Toxic Metal Ion Detection

Anas

Fen

Omar

et al. 2019

Sensors

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About 71% of the Earth’s surface is covered with water. Human beings, animals, and plants need water in order to survive. Therefore, it is one of the most important substances that exist on Earth. However, most of the water resources nowadays are insufficiently clean, since they are contaminated with toxic metal ions due to the improper disposal of pollutants into water through industrial and agricultural activities. These toxic metal ions need to be detected as fast as possible so that the situation will not become more critical and cause more harm in the future. Since then, numerous sensing methods have been proposed, including chemical and optical sensors that aim to detect these toxic metal ions. All of the researchers compete with each other to build sensors with the lowest limit of detection and high sensitivity and selectivity. Graphene quantum dots (GQDs) have emerged as a highly potential sensing material to incorporate with the developed sensors due to the advantages of GQDs. Several recent studies showed that GQDs, functionalized GQDs, and their composites were able to enhance the optical detection of metal ions. The aim of this paper is to review the existing, latest, and updated studies on optical sensing applications of GQDs-based materials toward toxic metal ions and future developments of an excellent GQDs-based SPR sensor as an alternative toxic metal ion sensor.

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A fluorometric and colorimetric dual-mode sensor based on nitrogen and iron co-doped graphene quantum dots for detection of ferric ions in biological fluids and cellular imaging

Abstract: A dual-mode sensing strategy based on N, Fe-GQDs for effective and selective detecting of Fe3+ and cellular imaging was developed.

Cited by 35 publications

References 40 publications

Synthesis of graphene quantum dots and their applications in drug delivery

Synthesis of graphene quantum dots and their applications in drug delivery

Recent Advances on Graphene Quantum Dots for Bioimaging Applications

Development of Graphene Quantum Dots-Based Optical Sensor for Toxic Metal Ion Detection

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