A flexible technology for modified release of drugs: multi layered tablets

Abdul, Shajahan; Poddar, Sushilkumar S.

doi:10.1016/j.jconrel.2004.03.034

Cited by 63 publications

(72 citation statements)

References 59 publications

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“…The difference of drug release characteristic of multilayered tablets depended on hydrophilicity of lower and upper barriers (35). In general, a constant drug release should be achieved when both barrier layers are hydrophilic and the core is hydrophobic (36)(37)(38). However, other factors also need to be considered to attain a zero-order drug release.…”

Section: Discussionmentioning

confidence: 99%

Double-Layered Matrix of Shellac Wax-Lutrol in Controlled Dual Drug Release

Phaechamud

Choncheewa

2015

AAPS PharmSciTech

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Abstract. Double-layered matrix tablets prepared from shellac wax-lutrol were fabricated using a molding technique, and the release of hydrochlorothiazide and propranolol HCl from the inner tablet or outer layer was studied. The simultaneous determination of dual drug release was measured with first derivative UV spectrophotometry. The tablet containing shellac wax as the outer tablet and lutrol as the inner tablet showed more appropriate drug release and the size of the inner layer influenced the rate of drug release. In addition, the aqueous solubility of the drug and the components of the inner tablet or outer layer affected the drug release behavior. Most of the double-layered tablets exhibited the drug-release pattern which fitted well with zero-order kinetic due to the restriction of the release surface. Biphasic drug release pattern was found in the tablet of which the outer layer rapidly eroded. The drug dissolution data from drug-loaded-outer layer could predict the dissolution time for the outer layer of drug-loaded inner part of double-layered matrix tablet. Incorporation of lutrol increased the drug release from shellac wax matrix, and the zero-order release was attained by fabricating it into a double-layered tablet.

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Section: Discussionmentioning

confidence: 99%

Double-Layered Matrix of Shellac Wax-Lutrol in Controlled Dual Drug Release

Phaechamud

Choncheewa

2015

AAPS PharmSciTech

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“…The swellable polymer relaxation and drug diffusion depend initially on the rate at which water may enter the device. Therefore, design of multi-layered matrix tablets is based on a rate factor (matrix hydration rate and diffusion rate) and a modulation factor (modulation of the surface and inner of matrix through which the drug can be delivered) (Abdul and Poddar, 2004). With these considerations, multi-layered matrix tablets may result in a linearization of the release profiles, which can help to facilitate the development process.…”

Section: Current Issues and Challenges Of Multi-layered Tabletsmentioning

confidence: 99%

“…Typical matrix-forming polymers are HPMC (hydroxypropyl methylcellulose), Na-CMC (sodium carboxymethyl cellulose), HPC (hydroxypropyl cellulose), MC (methylcellulose), Eudragit ® and natural gums. Among the various polymers, hydrophilic polymers are preferred in the modified release matrix tablets (Abdul and Poddar, 2004). The matrix tablet or capsule formulation can prolong the drug release profile relatively over a long period of time effectively with low cost and ease of manufacturing (Lee, 1992;Peppas, 1988).…”

mentioning

confidence: 99%

“…5 (2011) showed initial high release rate and followed by near firstorder diffusion due to the dissolution of the drug present at the surface of the matrix (Figure 1). The initial high release rate observed in the beginning of the release process is known as burst effect, which is often undesirable as it may have negative therapeutic effects (Abdul and Poddar, 2004). After the burst effect hydration and consequent swelling and/or erosion of the polymer occur.…”

mentioning

confidence: 99%

“…In other words, the polymer coated layers delay the interaction of active solute with dissolution medium, by limiting the surface available for the solute release and at the same time controlling solvent pen- Figure 1. Effect of the application of polymeric layers (barriers) on the drug release from a matrix core in a multi-layered tablet compared to a matrix tablet (modified from Abdul and Poddar, 2004).…”

mentioning

confidence: 99%

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Multi-Layered Matrix Tablets with Various Tablet Designs and Release Profiles

Choi¹,

Jeong²

2011

Journal of Pharmaceutical Investigation

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− Tablet dosage forms have been preferred over other formulations for the oral drug administration due to their low manufacturing costs and ease of administrations, especially controlled-release applications. Controlled-release tablets are oral dosage forms from which the active pharmaceutical ingredient (API) is released over an intended or extended period of time upon ingestion. This may allow a decrease in the dosing frequency and a reduction in peak plasma concentrations and hence improves patient compliance while reducing the risk of undesirable side effects. Conventional singlelayered matrix tablets have been extensively utilized to deliver APIs into the body. However, these conventional single-layered matrix tablets present suboptimal delivery properties, such as non-linear drug delivery profiles which may cause higher side effects. Recently, a multi-layered technology has been developed to overcome or eliminate the limitations of the singlelayered tablet with more flexibility. This technology can give a good opportunity in formulating new products and help pharmaceutical companies enhancing their life cycle management. In this review, a brief overview on the multi-layered tablets is given focusing on the various tablet designs, manufacturing issues and drug release profiles.

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Introduction and Overview of Oral Controlled Release Formulation Design

Wen

Park

2010

Oral Controlled Release Formulation Design and Drug Delivery

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A flexible technology for modified release of drugs: multi layered tablets

Cited by 63 publications

References 59 publications

Double-Layered Matrix of Shellac Wax-Lutrol in Controlled Dual Drug Release

Double-Layered Matrix of Shellac Wax-Lutrol in Controlled Dual Drug Release

Multi-Layered Matrix Tablets with Various Tablet Designs and Release Profiles

Introduction and Overview of Oral Controlled Release Formulation Design

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