Multi-Layered Matrix Tablets with Various Tablet Designs and Release Profiles

Abstract

− Tablet dosage forms have been preferred over other formulations for the oral drug administration due to their low manufacturing costs and ease of administrations, especially controlled-release applications. Controlled-release tablets are oral dosage forms from which the active pharmaceutical ingredient (API) is released over an intended or extended period of time upon ingestion. This may allow a decrease in the dosing frequency and a reduction in peak plasma concentrations and hence improves patient compliance while reducing the risk of undesirable side effects. Conventional singlelayered matrix tablets have been extensively utilized to deliver APIs into the body. However, these conventional single-layered matrix tablets present suboptimal delivery properties, such as non-linear drug delivery profiles which may cause higher side effects. Recently, a multi-layered technology has been developed to overcome or eliminate the limitations of the singlelayered tablet with more flexibility. This technology can give a good opportunity in formulating new products and help pharmaceutical companies enhancing their life cycle management. In this review, a brief overview on the multi-layered tablets is given focusing on the various tablet designs, manufacturing issues and drug release profiles.

Orally Fast Disintegrating Cyclodextrin/Prednisolone Inclusion-Complex Nanofibrous Webs for Potential Steroid Medications

“…It is obvious that the nanofibrous webs of HPβCD/prednisolone−IC and pullulan/prednisolone have identical characteristic peaks of drug molecules, suggesting the protection of the chemical structure of prednisolone during the entire period of the electrospinning process. 1 H-NMR might also be a convenient method to calculate the amount of drug molecules existing in the nanofibrous matrix. For this, prednisolone and the nanofibrous samples are dissolved in DMSO-d 6 to ensure the full dissolution of all components.…”

“…For the conformity of patients, oral drug delivery is a desirable way for the administration of drugs . In recent decades, orally disintegrating tablets (ODTs) have aroused growing interest in the pharmaceutical industry as an oral dosage form .…”

“…For the conformity of patients, oral drug delivery is a desirable way for the administration of drugs. 1 In recent decades, orally disintegrating tablets (ODTs) have aroused growing interest in the pharmaceutical industry as an oral dosage form. 2 ODTs represent acceptable safety and convenience compared to conventional tablet formulations since they can dissolve/ disintegrate in the oral cavity rapidly upon the contact with saliva, so there is no need of further liquid or chewing process during the administration.…”

A Potential Alternative Orodispersible Formulation to Prednisolone Sodium Phosphate Orally Disintegrating Tablets

“…Oral drug delivery is a preferable route of drug administration due to high patient compliance and ease of administration [ 1 ]. One particular oral dosage form, which showed a considerable potential in the last two decades is an orally disintegrating tablet (ODT), owing to its acceptability and safety profiles compared to the conventional tablets [ 2 ].…”

The effect of layer thickness ratio on the drug release behavior of alternating layered composite prepared by layer-multiplying co-extrusion

“…Many strategies have been developed to fabricate drug delivery systems with desirable drug release behaviors, such as stimulus-responsive drug delivery systems (Antoniou et al, 2021), nano drug delivery systems (Birk et al, 2021) and multi-layered drug delivery systems (Abdul and Poddar, 2004). Among these, multi-layered drug delivery (MLDD) systems are garnering increasing attention due to their inherent flexibility and controllability in drug release, extensive applicability, and the potential for continuous preparation (Abdul and Poddar, 2004;Choi and Jeong, 2011;Choi et al, 2013). Nowadays, MLDD systems can be prepared by layer-bylayer (LBL) self-assembly technology (Alkekhia et al, 2020), microfluidic technology (Liu et al, 2018), electrospinning technology (Laha et al, 2017) and lamination (Mazel and Tchoreloff, 2021).…”