A Flexible Stent with Small Intestinal Submucosa Covering for Direct Intrahepatic Portocaval Shunt: Experimental Pilot Study in Swine

Niyyati, Mahtab; Petersen, Bryan D.; Pavčnik, Dušan; Uchida, Barry T.; Timmermans, Hans A.; Hiraki, Takao; Wu, Reng Hong; Brountzos, Elias; Keller, Frederick S.; Rösch, Josef

doi:10.1007/s00270-003-0261-0

Cited by 7 publications

(6 citation statements)

References 21 publications

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“…Notable advantages of xenogeneic ECMs in this setting are their non‐immunogenic nature and ability to stimulate a constructive tissue remodeling response after implantation. However, the absence of a confluent host‐derived endothelium throughout the ECM after long‐term in vivo implantation has delayed the progress of this novel surgical concept …”

Section: Introductionmentioning

confidence: 99%

Development of a rotational cell‐seeding system for tubularized extracellular matrix (ECM) scaffolds in vascular surgery

et al. 2013

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Tubularized porcine extracellular matrices (ECMs) are under investigation as adjuvant scaffolds for endovascular aneurismal repair (EVAR). Limitations with tubularized ECMs in this setting include difficulties in achieving a confluent endothelium on the scaffold's luminal surface prior to in vivo implantation. In this in vitro study a rotational "cell-seeding rig" (RCR) was constructed to assess the potential for endothelialization of tubular ECM constructs. Human aortic endothelial cells (HAECs) were cultured onto the luminal surfaces of tubular porcine urinary bladder matrix (UBM) scaffolds and rotated in the RCR at experimental rotational speeds. Results showed that endothelial attachment occurred at a rotation speed of six revolutions per hour. HAECs continued to proliferate after the initial attachment period of 24 h and formed a confluent endothelial monolayer after 14 days of growth. Our results demonstrate that RCRs facilitate attachment of HAECs in vitro at a speed of six revolutions per hour. The endothelialization technique presented in the current study may be important for advancing tissue-engineering approaches to address some of the current limitations in endovascular treatments of abdominal aortic aneurysms.

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Section: Introductionmentioning

confidence: 99%

Development of a rotational cell‐seeding system for tubularized extracellular matrix (ECM) scaffolds in vascular surgery

et al. 2013

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“…(Schoder et al, 2004) In 2005 Niyyati et al assessed the potential for SIS as an intrahepatic protocaval shunt. Only one device remained functional in 6 animals after a 14 day experimental time period (Niyyati et al 2005). Intuitively, the authors discouraged SIS in this setting.…”

Section: Configurations Of Ecm Stent Grafts For Evarmentioning

confidence: 99%

“…6 A and B. Histological assessment of the luminal surface after follow up demonstrated a smooth neointima on the surface of the functional stent. (Niyyati et al 2005) A more recent study investigated the effects of different stent grafts on the portal vein of canine models (Ishii et al, 2005). In this study, four different stents were assessed, bare metal stent, PTFE covered stent, Dacron covered stent and an SIS covered stent.…”

Section: Configurations Of Ecm Stent Grafts For Evarmentioning

confidence: 99%

“…A reliable method that prevents these complications from occurring is an attractive option. (Brown et al 2006, Schoder et al, 2004, Niyyati et al 2005, Yavuz et al 2006 suggest that tissue-engineered extracellular matrix (ECM) scaffolds derived from xenogenic sources may have the potential to overcome limitations that are associated with traditional mechanical solutions.…”

Section: Complications Associated With Evarmentioning

confidence: 99%

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Tissue-Engineered Extracellular Matrices (ECMs) as Adjuvant Scaffolds for Endovascular Aneurysmal Repair (EVAR)

Callanan¹,

Davis²,

Walsh³

et al. 2011

Regenerative Medicine and Tissue Engineering - Cells and Biomaterials

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“…Finally, a recent study by Niyyati et al (19) described the use of intravascular US and a self-expanding stent with a submucosal covering to create a portacaval shunt.…”

Section: Percutaneous Extrahepatic Portosystemic Shuntsmentioning

confidence: 99%

Evaluation of MR/Fluoroscopy–guided Portosystemic Shunt Creation in a Swine Model

Arepally

Karmarkar

Qian

et al. 2006

Journal of Vascular and Interventional Radiology

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RESULTS: Successful MR-guided IVC/SMV punctures were performed in all 20 procedures (100%). All three shunts were deployed. Stent-grafts had the poorest mechanism for securing a shunt. The vascular anastomotic device and the bridging stent had more secure anchoring mechanisms but also had higher technical failure rates (50% and 40%, respectively). When deployed successfully, the vascular anastomotic device resulted in no bleeding at the sites of punctures at necropsy. CONCLUSION: Percutaneous shunts and vascular anastomoses between the portal mesenteric venous system and IVC were successfully created with use of a combination of MR imaging and conventional fluoroscopy for guidance.

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A Flexible Stent with Small Intestinal Submucosa Covering for Direct Intrahepatic Portocaval Shunt: Experimental Pilot Study in Swine

Cited by 7 publications

References 21 publications

Development of a rotational cell‐seeding system for tubularized extracellular matrix (ECM) scaffolds in vascular surgery

Development of a rotational cell‐seeding system for tubularized extracellular matrix (ECM) scaffolds in vascular surgery

Tissue-Engineered Extracellular Matrices (ECMs) as Adjuvant Scaffolds for Endovascular Aneurysmal Repair (EVAR)

Evaluation of MR/Fluoroscopy–guided Portosystemic Shunt Creation in a Swine Model

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