A flexible and biocompatible bombyx mori silk fibroin/wool keratin composite scaffold with interconnective porous structure

Tian, Yan; Wu, Qinting; Li, Fang; Zhou, Yuhang; Huang, Di; Xie, Ranhong; Wang, Xiaoqin; Zheng, Zhaozhu; Li, Gang

doi:10.1016/j.colsurfb.2021.112080

Cited by 19 publications

(17 citation statements)

References 36 publications

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“…It has been intensively used as sutures due to its high biocompatibility with the human organism. There are numerous reports that have confirmed this extraordinary property of SF [ 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ].…”

Section: Sf Key Propertiesmentioning

confidence: 92%

The Contribution of Silk Fibroin in Biomedical Engineering

Lujerdean

Baci

Cucu

et al. 2022

Insects

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Silk fibroin (SF) is a natural protein (biopolymer) extracted from the cocoons of Bombyx mori L. (silkworm). It has many properties of interest in the field of biotechnology, the most important being biodegradability, biocompatibility and robust mechanical strength with high tensile strength. SF is usually dissolved in water-based solvents and can be easily reconstructed into a variety of material formats, including films, mats, hydrogels, and sponges, by various fabrication techniques (spin coating, electrospinning, freeze-drying, and physical or chemical crosslinking). Furthermore, SF is a feasible material used in many biomedical applications, including tissue engineering (3D scaffolds, wounds dressing), cancer therapy (mimicking the tumor microenvironment), controlled drug delivery (SF-based complexes), and bone, eye and skin regeneration. In this review, we describe the structure, composition, general properties, and structure–properties relationship of SF. In addition, the main methods used for ecological extraction and processing of SF that make it a green material are discussed. Lastly, technological advances in the use of SF-based materials are addressed, especially in healthcare applications such as tissue engineering and cancer therapeutics.

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Section: Sf Key Propertiesmentioning

confidence: 92%

The Contribution of Silk Fibroin in Biomedical Engineering

Lujerdean

Baci

Cucu

et al. 2022

Insects

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“…However, in this eld, materials need to be used in the physiological environment, which requires that they maintain a certain water absorption rate to ensure the diffusion and exchange of nutrients and metabolic waste during the repair process. [5][6][7] Moreover, they must retain specic mechanical properties to ensure adequate resistance to damage and deformation aer implantation. [8][9][10][11] During the synthesis of WPU materials, high-molecular-weight prepolymers are required to enhance the mechanical properties of the material.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of completely solvent-free biomedical waterborne polyurethane with excellent mechanical property retention and satisfactory water absorption

Zhen,

Zhang,

Wang

et al. 2024

J. Mater. Chem. A

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“…CS is anti‐bacterial and has good biocompatibility with its structure similar to amino polysaccharides in extracellular matrix (ECM) and its degradation product chitooligosaccharide can inhibit neuronal apoptosis, support cell adhesion, and promote injured axonal regeneration 18,19 . SF has been widely studied due to its good physical properties, chemical properties, biocompatibility, and controllable degradability into polypeptides 20–22 . Interestingly, free amino acids can be further absorbed by human body to promote the growth of nerve cells.…”

Section: Introductionmentioning

confidence: 99%

“…18,19 SF has been widely studied due to its good physical properties, chemical properties, biocompatibility, and controllable degradability into polypeptides. [20][21][22] Interestingly, free amino acids can be further absorbed by human body to promote the growth of nerve cells. Magnesium metals have been reported in the biomedical research, such as bone repair, 23 cardiovascular stents, 24 and nerve repair.…”

mentioning

confidence: 99%

Preparation and mechanical optimization of a two‐layer silk/magnesium wires braided porous artificial nerve guidance conduit

Zhao

Zhang

Duan

et al. 2022

J Biomedical Materials Res

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Peripheral nerve injures have long been a tricky problem in surgery and a feasible treatment is the transplantation of nerve guidance conduits (NGCs). This study presents a two‐layer composite NGC with fair mechanical properties and good biocompatibility. The inner layer was made of degummed silk yarns/magnesium wires using braiding technology, and the outer layer was made from mixed solution of silk fibroin/chitosan (SF/CS) using freeze‐drying treatment. Orthogonal experimental design was applied to rationally design the braided structural layer and obtain the optimal combination of technical process parameters. Meanwhile, the SF/CS porous outer layer was optimized from three concentrations of SF/CS solution. In vitro and in vivo study suggested that the textile‐forming scaffold exhibited good biocompatibility and no toxicity. During 4 weeks' degradation, the skeleton of conduits retained its shape, and magnesium ions released from degraded magnesium wires contributed to sustainable release and uniform dispersion, proliferation and adhesion of Schwann cells, indicating potential approach in the development of NGCs.

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A flexible and biocompatible bombyx mori silk fibroin/wool keratin composite scaffold with interconnective porous structure

Cited by 19 publications

References 36 publications

The Contribution of Silk Fibroin in Biomedical Engineering

The Contribution of Silk Fibroin in Biomedical Engineering

Synthesis of completely solvent-free biomedical waterborne polyurethane with excellent mechanical property retention and satisfactory water absorption

Preparation and mechanical optimization of a two‐layer silk/magnesium wires braided porous artificial nerve guidance conduit

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