A flavonoid with cytotoxic activity and other constituents from Centaurea africana

Seghiri, Ramdane; Boumaza, Ouahiba; Mekkiou, R.; Benayache, Samir; Mosset, Paul; Quintana, José; Estévez, Francisco; León, Francisco; Bermejo, Jaime; Benayache, Fadila

doi:10.1016/j.phytol.2009.03.002

Cited by 31 publications

(20 citation statements)

References 23 publications

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“…Many Centaurea species are used traditionally for medicinal purposes, including Centaurea pulchella, Centaurea drabifolia, Centaurea triumfettii, Centaurea depressa, and Centaurea virgate. Various biological activities of the members of the genus Centaurea L. have been reported previously, such as cytogenetic (Radic et al, 2005), antiinflammatory (Garbacki et al, 1999;Erel et al, 2011Erel et al, , 2014, anticancer , and cytotoxic activities (Seghiri et al, 2009;Ahmed and Kamel, 2014). The chemical composition of the members of this genus was also reported in other studies (Dural et al, 2003;Beltagy, 2015).…”

Section: Introductionsupporting

confidence: 52%

Cytotoxic and apoptotic effects of endemic Centaurea fenzlii Reichardt on the MCF-7 breast cancer cell line

Yırtıcı¹,

Göğer²,

Sarimahmut³

et al. 2017

Turk J Biol

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Section: Introductionsupporting

confidence: 52%

Cytotoxic and apoptotic effects of endemic Centaurea fenzlii Reichardt on the MCF-7 breast cancer cell line

Yırtıcı¹,

Göğer²,

Sarimahmut³

et al. 2017

Turk J Biol

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“…found to exhibit of antitumor and cytotoxic activity. [18,[20][21][22] Methanolic and aqueous extracts were tested for their cytotoxic activity on HeLa and Vero cell line by the MTT assay. The results indicate that aqueous extracts exhibit very low cytotoxic activity.…”

Section: Referencesmentioning

confidence: 99%

“…[4,6] Members of Centaurea species were proposed to have antimicrobial, [5,[7][8][9][10] antifungal, [8,11] anti-inflammatory, [12] anti-ulcerogenic, [13] antioxidant, [14][15][16][17] antiplasmodial, [18] antiprotozoal, [8] antiviral [19] and cytotoxic [18,[20][21][22] activities. C. calcitrapa which grows up on northwestern Anatolia is used (2-6% infusion) as a fever reducer.…”

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confidence: 99%

Total Phenolic Contents, Antioxidant Activities Cytotoxicity of Three Centaurea Species: C. calcitrapa subsp. calcitrapa, C. ptosimopappa C. spicata

Erol-Dayi

Pekmez

Bona

et al. 2011

Free Radicals and Antioxidants

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Background: Many species of the genus Centaurea have been reported to be used in Anatolian folk medicine. In the present study, methanolic and aqueous extracts of three species of Centaurea L. (C. calcitrapa subsp. calcitrapa, C. ptosimopappa and C. spicata) have been assessed for antioxidant and cytotoxic activities. Materials and Methods: Antioxidant activity was investigated by DPPH and superoxide anion scavenging and anti-lipid peroxidation assays. Cytotoxic effect on HeLa and Vero cells were investigated by MTT assay. Results: Superoxide anion scavenging activities of aqueous extracts were higher than those of methanolic extracts, and the highest activity was detected in the aqueous extracts of C. calcitrapa subsp. calcitrapa with the IC 50 value of 25.91 µg/mL. The methanolic extract of C. ptosimopappa showed the strongest anti-lipid peroxidation activity. Total phenolic contents (mg gallic acid equivalent per gram) were ranged between 17.25 and 120.50 and the highest value was detected in aqueous extract of C. ptosimopappa. The highest cytotoxic activity was observed in the methanolic extract of C. calcitrapa subsp. calcitrapa on both cell lines with the IC 50 values of <100 µg/mL. Conclusions: According to the results of activity tests, the selected Centaurea species, especially C. calcitrapa subsp. calcitrapa can be regarded as a potential source of natural antioxidants in the prevention and treatment of diseases in which oxidants or free radicals are implicated.Key-words: Antioxidant activity; Centaurea; Cytotoxicity; Free radical scavenging.Key Messages: The selected Centaurea species showed an antioxidant activity and very low cytotoxic activity. Thus, Centaurea species might be a good candidate for further studies targeting the development of new antioxidants.

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“…Around 13 species of Centaurea are growing in Egypt. Centaurea species, have been the object of various phytochemical studies, with a diversity of bioactive phytochemicals and prevalence of flavonoids (Flamini et al, 2001;Shoeb et al, 2007;Seghiri et al, 2009) and sesquiterpene lactones . Centaurea species are claimed for their uses in gastrointestinal and inflammatory disorders, hypotensive and cytotoxic activities, in addition to the anti-bacterial impacts alone or when mixed with different plants (Farrag et al, 1993;Kargıoglu et al, 2010; Köse et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

PHENOLIC PROFILE OF Centaurea aegyptiaca L. GROWING IN EGYPT AND ITS CYTOTOXIC AND ANTIVIRAL ACTIVITIES

Bakr¹,

Mohamed²,

Ayoub³

2016

Afr J Tradit Complement Altern Med

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Background: Centaurea aegyptiaca L (Asteraceae), is one of the most attractive plants growing wildly in Sinai, and is not well investigated for its phytochemical constituents. This study represents the first in-depth characterization of the phenolic profile of the aerial parts of C. aegyptiaca methanolic extract utilizing liquid chromatography (LC) combined with electrospray ionization (ESI) tandem mass spectrometry (MS/MS). Material and Methods: Phenolic profile was researched utilizing LC-HRESI-MS-MS. Assessment of cytotoxic activity against four human cancer cell lines (Hep-G2; hepatocellular carcinoma cells, MCF-7; breast adenocarcinoma cells, and HCT-116; colon carcinoma and HELA; cervical carcinoma cells) was performed using 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay. Antiviral activity was surveyed utilizing cytopathic effect inhibition assay. Results: A total of sixty-one compounds were tentatively distinguished (twenty-one phenolic acids and their derivatives, thirty-one flavonols and nine flavones) in the negative and positive modes. Centaurea aegyptiaca demonstrated outstanding results against Hep-G2, MCF-7, HCT-116 and HELA cell lines with IC 50 of 12.1, 30.9, 11.7 and 19.5 µg/mL respectively compared and doxorubicin as a reference drug. Weak antiviral activity was seen against hepatitis A virus (HAV) and no impact against herpes simplex virus type 1 (HSV 1). Conclusion:This study provides a better understanding of the chemistry of C. aegyptiaca that announces itself as a promising cytotoxic agent.

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A flavonoid with cytotoxic activity and other constituents from Centaurea africana

Cited by 31 publications

References 23 publications

Cytotoxic and apoptotic effects of endemic Centaurea fenzlii Reichardt on the MCF-7 breast cancer cell line

Cytotoxic and apoptotic effects of endemic Centaurea fenzlii Reichardt on the MCF-7 breast cancer cell line

Total Phenolic Contents, Antioxidant Activities Cytotoxicity of Three Centaurea Species: C. calcitrapa subsp. calcitrapa, C. ptosimopappa C. spicata

PHENOLIC PROFILE OF Centaurea aegyptiaca L. GROWING IN EGYPT AND ITS CYTOTOXIC AND ANTIVIRAL ACTIVITIES

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