A flavonoid compound from<i>Chrysosplenium nudicaule</i>inhibits growth and induces apoptosis of the human stomach cancer cell line SGC-7901

Luo, Yanping; Yu, Hongbin; Yang, Yun‐Shang; Tian, Weihua; Dong, Kaizhong; Shan, Jinyu; Ma, Xingming

doi:10.3109/13880209.2015.1055634

Cited by 18 publications

(11 citation statements)

References 30 publications

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“…The most distinctive marker of MMP is the dissipation of the mitochondrial transmembrane potential (Δψ). Δψ results from the asymmetric distribution of protons and other ions on both sides of the inner mitochondrial membrane, thus creating a chemical (pH) and electric gradient that is essential for mitochondrial function (13). Cells undergoing apoptosis exhibit a decreased Δψ (14).…”

Section: Discussionmentioning

confidence: 99%

Ultrasound hyperthermia induces apoptosis in head and neck squamous cell carcinoma: an in vitro study

Ren¹,

Jv²,

Tian³

et al. 2017

Med Oral

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BackgroundHyperthermia is considered an efficient complement in the treatment of head and neck squamous cell carcinoma (HNSCC). Hyperthermia induces cell apoptosis in a temperature- and time-dependent manner. However, the molecular mechanism of hyperthermia remains unclear. The aim of this study was to investigate the mechanism of apoptosis induced by ultrasound hyperthermia in HNSCC cell lines HN-30 and HN-13.Material and MethodsWe examined the dynamic changes of early apoptosis and secondary necrosis in HN-30 and HN-13 cells treated by hyperthermia at 42°C for 10 min. We further examined mitochondrial membrane potential in vitro by ultrasound hyperthermia for different heating temperatures (38-44°C, 10 min) and heating times (42°C, 10-50 min). After heating by ultrasound at 42°C for 10 min, the apoptosis index achieved its highest level at 8 h after treatment, decreased rapidly and remained constant at a reduced level at 12 h.ResultsThe level of secondary necrosis increased with the level of early apoptosis but remained at a higher level until 14 h. The level of secondary necrosis correlated with the level of early apoptosis (HN-13: r=0.7523, P=0.0030; HN-30: r=0.6510, P=0.016). The fractions of cells with low mitochondrial membrane potential (Δψ) in the heating-temperature grads group and heating-time grads group decreased significantly over time. Therefore, HN-30 and HN-13 cells developed apoptosis after ultrasound hyperthermia treatment with decreases in the mitochondrial transmembrane potential level.ConclusionsUltrasound hyperthermia induces apoptosis in HN-30 and HN-13 cells, possibly via the mitochondrial caspase pathway. Key words:Head and neck squamous cell carcinoma, apoptosis, mitochondrial membrane potential, ultrasound hyperthermia.

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Section: Discussionmentioning

confidence: 99%

Ultrasound hyperthermia induces apoptosis in head and neck squamous cell carcinoma: an in vitro study

Ren¹,

Jv²,

Tian³

et al. 2017

Med Oral

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“…6, 7, 30-trimethoxy-3, 5, 40-trihydroxy flavone (TTF), extracted from Chrysosplenium nudicaule Ledeb. Herba, is a well known traditional Chinese medicine for digestive diseases [49]. TTF induced apoptosis on SGC-7901 cells treated at the dose of 2, 4, 8, 16, 32 μg/mL for 24, 48 and 72 h. Sun et al observed that curcumin, isolated from Curcuma longa L. Rhizoma (Zingiberaceae), induced apoptosis of SGC-7901 and BGC-823 (5, 10, 15, 20, 40 μM for 24 h) cells by up-regulating microRNA-33b (miR-33b) expression [50].…”

Section: Apoptosis-inducing Natural Molecules In Gastric Cancermentioning

confidence: 99%

Emerging Potential of Naturally Occurring Molecules against Gastric Cancer: Insights Molecular Mechanism and Therapeutic Targets

Kang¹,

Hwang²,

Shin³

et al. 2021

Preprint

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Gastric cancer, also known as stomach cancer, is a cancer which develops from the lining of the stomach. Accumulated evidences and epidemiological studies have been indicated that natural products play an important role in gastric cancer prevention and treatment, although its mechanism of action did not elucidate yet. Particularly, experimental studies have been showed that natural products displayed a protective effect against gastric cancer via numerous molecular mechanisms such as suppression of cell metastasis, anti-angiogenesis, inhibition of cell proliferation, induction of apoptosis, and modulation of autophagy. Although chemotherapy remains the standard treatment for advanced gastric cancer along with surgery, radiation therapy, hormone therapy and immunotherapy, but its adverse side effects including neutropenia, stomatitis, mucositis, diarrhea, nausea, and emesis are well documented. Additionally, intake of naturally occurring phytochemicals could increase the efficacy of gastric chemotherapy and chemotherapeutics resistance. However, natural product structural stability and powerful bioactivity are important to develop novel treatments for gastric cancer that may minimize such adverse effects. Therefore, the purpose of this review is to summarize the potential therapeutic effects of natural products on prevention and treatment of gastric cancer with intensive molecular mechanisms of action, bioavailability, and safety efficacy.

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“…Chrysosplenium is divided into two subgenera according to the leaf arrangement: Alternifolia Franchet with alternate leaves and Oppositifolia Franchet with opposite leaves [4,8,10]. Some species within the genus have been used in traditional Tibetan medicine to treat digestive system diseases [11].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Six Chloroplast Genomes Provides Insight into the Evolution of Chrysosplenium (Saxifragaceae)

Liao

Yang

et al. 2020

Preprint

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Background Chrysosplenium L. (Saxifragaceae) is a genus of plants widely distributed in China and usually found in moist, shaded valleys and mountain slopes. This genus is ideal for studying plant adaptation to low-light conditions. Although some progress has been made in the systematics and biogeography of Chrysosplenium, its chloroplast genome evolution remains to be investigated. Results To fill this gap, we sequenced the chloroplast genomes of six Chrysosplenium species and analyzed their genome structure, GC content, and nucleotide diversity. Moreover, we performed a phylogenetic analysis and calculated non-synonymous (Ka)/synonymous (Ks) substitution ratios using the combined protein-coding genes of 29 species within Saxifragales and two additional species as outgroups, as well as a pair-wise estimation for each gene within Chrysosplenium. Compared with the outgroups in Saxifragaceae, the six Chrysosplenium chloroplast genomes had lower GC contents; they also had conserved boundary regions and gene contents, as only the rpl32 gene was lost in four of the Chrysosplenium chloroplast genomes. Phylogenetic analyses suggested that the Chrysosplenium separated to two major clades (the opposite group and the alternate group). The pair-wise Ka/Ks ratios of genes in the Chrysosplenium species showed that matK and ycf2 were subjected to relatively relaxed selection. Conclusion This study provides genetic resources for exploring the phylogeny of Chrysosplenium and sheds light on plant adaptation to low-light conditions. The lower average GC content and the lacking gene of rpl32 indicating selective pressure in their unique habitats. Different from results previously reported, our selective pressure estimation suggested that the genes related to photosynthesis (such as ycf2) were under positive selection at sites in the coding region.

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A flavonoid compound fromChrysosplenium nudicauleinhibits growth and induces apoptosis of the human stomach cancer cell line SGC-7901

Cited by 18 publications

References 30 publications

Ultrasound hyperthermia induces apoptosis in head and neck squamous cell carcinoma: an in vitro study

Ultrasound hyperthermia induces apoptosis in head and neck squamous cell carcinoma: an in vitro study

Emerging Potential of Naturally Occurring Molecules against Gastric Cancer: Insights Molecular Mechanism and Therapeutic Targets

Analysis of Six Chloroplast Genomes Provides Insight into the Evolution of Chrysosplenium (Saxifragaceae)

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