A first study of antibacterial activity of diterpenes isolated from some Salvia species (Lamiaceae)

González, Antonio G.; Abad, Teresa; Jiménez, Ignacio A.; Ravelo, Ángel G.; Aguiar, Javier G. Luis Zahira; Andrés, Lucía S.; Plasencia, Mercedes; Herrera, Juan R.; Moujir, Laila

doi:10.1016/0305-1978(89)90005-7

Cited by 50 publications

(30 citation statements)

References 11 publications

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“…There has been comparatively little investigation on the effects of essential oils on marine bacteria that have the potential to cause disease in important aquaculture industries (Rattanachaikunsopon and Phumkhachorn 2007;Asha et al 2008). Some studies on the antimicrobial activities of essential oils and herbal extracts for controlling aquatic animal diseases have been reported (Bailey 1984;Gonzales et al 1989;Cooper et al 1997;Lilley and Inglis 1997;Rattanachaikunsopon and Phumkhachorn 2007;Asha et al 2008). However, only a few reports have tested combinations of these products for their synergistic antimicrobial activities (Lee et al 2007).…”

Section: Introductionmentioning

confidence: 97%

Antibacterial activities of a new combination of essential oils against marine bacteria

et al. 2010

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The antibacterial activities of essential oils and herbal extracts have been demonstrated against a range of bacterial species. In this study, the antibacterial effects of a new combination of essential oils from the herbs Thymus vulgaris, Salvia officinalis, Eucalyptus globulus and Mentha piperita were assayed against common bacterial isolates (Staphylococcus aureus, Escherichia coli and Pseudomonas aeroginosa) and fifteen novel marine bacteria isolates. The sensitivity of different isolates to antibacterial activity of the essential oils was determined using well diffusion assays. Minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) were quantified by micro dilution assays. The data demonstrate that the combination of essential oils had potent antibacterial effects and marine bacteria were more sensitive to growth inhibition (P \ 0.05). MIC rates were 0.77-6.18 mg/ml, and MBC rates were 1.67-12.30 mg/ml. This indicates that the combined essential oils (CEO) can be a new source of antibacterial agents for use in marine aquaculture.

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Section: Introductionmentioning

confidence: 97%

Antibacterial activities of a new combination of essential oils against marine bacteria

et al. 2010

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“…The genus Salvia belongs to the Lamiaceae family, comprises numerous species and shows diverse biological activities manifested by the different components, that allow for the many medicinal and pharmaceutical applications of the plant materials and/or extracts. In fact, many diterpenes, isolated from plants of several species of the genus Salvia, have been demonstrated to have interesting pharmacological properties, such as antioxidant (Lima et al, 2005), antimicrobic (Gonzales et al, 1987), antiinflammatory, analgesic (Hosseinzadeh et al, 2003), antipyretic, hemostatic (Hernandez-Perez et al, 1995), hypoglycemic (Alarcon-Aguilar et al, 2002) and antitumor (Liu et al, 2000). Indeed, Salvia miltiorrhiza Bunge, commonly used in traditional Chinese herbal medicine to treat cardiovascular and hepatic disorders, has been shown recently to have a significant antitumoral property (Chang et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

In vitro antiproliferative effect of six Salvia species on human tumor cell lines

Fiore

Nencini

Cavallo

et al. 2006

Phytotherapy Research

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This study was designed to examine the in vitro antiproliferative activity of the methanol crude extracts of six Salvia species: Salvia dominica L. leaves, Salvia lanigera Desf. aerial parts, Salvia menthaefolia Ten. roots, Salvia palaestina Benth. aerial parts, Salvia sclarea L. roots and Salvia spinosa L. aerial parts. Extracts were screened for their possible antitumoral activity by MTT test on nine human cancer cell lines: glioblastoma (DBTRG-05MG, T98G, U-87MG), colorectal adenocarcinoma (WiDr and HT-29), prostate adenocarcinoma (MDA Pca2b), choriocarcinoma (JEG-3), endometrium adenocarcinoma (HEC-1A) and B lymphoblast (CIR). IC(50) values were determined for only five extracts and ranged from 90 to 400 microg/mL approximately. Salvia menthaefolia extract exhibited marked antiproliferative activity against all tumor cell lines showing lower IC(50) values, while S. spinosa, S. sclarea and S. dominica extracts showed a degree cytotoxic activity dependent on the cell line type. Finally S. palaestina extract revealed a moderate antiproliferative effect only against three cell lines. Salvia lanigera extract displayed toxic activity at all concentrations tested. The results strengthen the evidence that the genus Salvia could be considered a natural resource of potential antitumor agents.

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“…The genus Salvia includes more than 900 species and is now being intensively studied in view of the antioxidant, antibacterial and antifungal properties that many exudation products, mainly containing ursolic and oleanolic acids, have been shown to posses [22][23][24][25].…”

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confidence: 99%

Effects of demethylfruticuline A and fruticuline A from Salvia corrugata Vahl. on biofilm production in vitro by multiresistant strains of Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis

Schito

Piatti

Stauder

et al. 2011

International Journal of Antimicrobial Agents

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In this study, demethylfruticuline A (dfA) and fruticuline A (fA), two quinones representing the mayor diterpenoid components of the exudate produced by the aerial parts of Salvia corrugata, were assessed for their ability to modify surface characteristics, such as hydrophobicity, and to inhibit synthesis of biofilm in vitro by multiresistant Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis. Five strains of S. aureus (three meticillin-resistant and two meticillinsusceptible), five strains of S. epidermidis (four meticillin-resistant and one meticillinsusceptible) and eight vancomycin-resistant E. faecalis, all recently isolated from clinical specimens and capable of slime production, were studied. fA decrease by at least two-fold the hydrophobic properties of the S. aureus cell membrane but did not affect S. epidermidis or E. faecalis. Biofilm formation on polystyrene plates was quantified spectrophotometrically by established methodologies. Inhibition of biofilm formation was also confirmed by the Congo red agar plate assay. dfA and fA were more effective against S. aureus strains (>70% effect at subinhibitory concentrations) than against S. epidermidis in inhibiting slime synthesis. Against E. faecalis, dfA at subinhibitory concentration induced an inhibition of biofilm production of ca. 60%; fA was less active and more strain-dependent. Moreover, the two compounds were shown to posses chelating activity on divalent and trivalent metal cations.Interactions of fA and dfA with bacteria could be very complex, possibly being species-specific, and could depend not only on inhibition of exopolysaccharide synthesis but also on their chelating activity and on changes in the microorganism's surface, including cell hydrophobicity.

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A first study of antibacterial activity of diterpenes isolated from some Salvia species (Lamiaceae)

Cited by 50 publications

References 11 publications

Antibacterial activities of a new combination of essential oils against marine bacteria

Antibacterial activities of a new combination of essential oils against marine bacteria

In vitro antiproliferative effect of six Salvia species on human tumor cell lines

Effects of demethylfruticuline A and fruticuline A from Salvia corrugata Vahl. on biofilm production in vitro by multiresistant strains of Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis

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