A Fe3O4@Au-basedpseudo-homogeneous electrochemical immunosensor for AFP measurement using AFP antibody-GNPs-HRP as detection probe

Yuan, Yuexing; Li, Shanshan; Xue, Yewei; Liang, Jianwei; Cui, Lijie; Li, Qingbo; Zhou, Sufang; Huang, Yong; Li, Guiyin; Zhao, Yongxiang

doi:10.1016/j.ab.2017.07.015

Cited by 55 publications

(16 citation statements)

References 37 publications

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“…The limit of detection was calculated to be 1.5 pg/mL. Compared with other related reports (Jiao et al, 2016;Wei et al, 2016;Yuan et al, 2017;Li et al, 2018), this experimental result has a wider linear range and lower detection. The results show that Au nanostructures can be used as a labeling material to immobilize more antibodies and enzymes, which greatly improves the sensitivity and signal response of the electrode, so that the electrode has a wider linear range and lower detection limit.…”

Section: Resultsmentioning

confidence: 46%

An Electrochemical Sandwich Immunosensor Based on Signal Amplification Technique for the Determination of Alpha-Fetoprotein

et al. 2020

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The synthesis of Au nanocubes is used to label alpha-fetoprotein antibody (anti-AFP) and horseradish peroxidase (HRP) to form an immune complex for antibody detection. Graphene oxide-methylene blue-gold nanoparticles (GO-MB-AuNPs) nanocomposites were used as the immunosensing platform. This proposed sandwich-type immunoassay shows good performance. This method establishes a feasible amperometric immunoassay method for sensitive analysis of AFP in serum samples. Under the optimal experimental conditions, the DPV current response of the immunosensor is proportional to the logarithmic value of the AFP concentration. The linear detection range can achieve to 0.005-20 ng/mL with a detection limit of 1.5 pg/mL. The proposed immunosensor has good precision, selectivity and stability, and can be used for AFP determination in clinical tests.

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Section: Resultsmentioning

confidence: 46%

An Electrochemical Sandwich Immunosensor Based on Signal Amplification Technique for the Determination of Alpha-Fetoprotein

et al. 2020

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“…5b). The limit detection was 2.3 pg/mL, which is much lower than many of electrochemical immunosensors with intricate signal amplifying strategy based on two-dimensional (2D) electrode [33][34][35][36][37][38].…”

Section: Analytical Performancementioning

confidence: 90%

Highly sensitive and selective electrochemical immunosensors by substrate-enhanced electroless deposition of metal nanoparticles onto three-dimensional graphene@Ni foams

Zhao

et al. 2019

Science Bulletin

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“…In the second route, called also one-step route, the Fe 3− x O 4 surface is directly coated by a gold layer [ 51 , 52 ]. This implies that Au atoms are directly deposited onto Fe 3− x O 4 through the reduction of Au(III) precursors ( Figure 6 ).…”

Section: Structure and Synthesis Of Magneto-plasmonic Nanostructurmentioning

confidence: 99%

Iron Oxide and Gold Based Magneto-Plasmonic Nanostructures for Medical Applications: A Review

2018

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Iron oxide and gold-based magneto-plasmonic nanostructures exhibit remarkable optical and superparamagnetic properties originating from their two different components. As a consequence, they have improved and broadened the application potential of nanomaterials in medicine. They can be used as multifunctional nanoprobes for magneto-plasmonic heating as well as for magnetic and optical imaging. They can also be used for magnetically assisted optical biosensing, to detect extreme traces of targeted bioanalytes. This review introduces the previous work on magneto-plasmonic hetero-nanostructures including: (i) their synthesis from simple “one-step” to complex “multi-step” routes, including seed-mediated and non-seed-mediated methods; and (ii) the characterization of their multifunctional features, with a special emphasis on the relationships between their synthesis conditions, their structures and their properties. It also focuses on the most important progress made with regard to their use in nanomedicine, keeping in mind the same aim, the correlation between their morphology—namely spherical and non-spherical, core-satellite and core-shell, and the desired applications.

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A Fe3O4@Au-basedpseudo-homogeneous electrochemical immunosensor for AFP measurement using AFP antibody-GNPs-HRP as detection probe

Cited by 55 publications

References 37 publications

An Electrochemical Sandwich Immunosensor Based on Signal Amplification Technique for the Determination of Alpha-Fetoprotein

An Electrochemical Sandwich Immunosensor Based on Signal Amplification Technique for the Determination of Alpha-Fetoprotein

Highly sensitive and selective electrochemical immunosensors by substrate-enhanced electroless deposition of metal nanoparticles onto three-dimensional graphene@Ni foams

Iron Oxide and Gold Based Magneto-Plasmonic Nanostructures for Medical Applications: A Review

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