A Family Study of Obsessive-compulsive Disorder

Nestadt, Gerald; Samuels, Jack; Riddle, Mark A.; Bienvenu, O. Joseph; Liang, Kung Yee; LaBuda, Michele C.; Walkup, John T.; Grados, Marco A.; Hoehn‐Saric, Rudolf

doi:10.1001/archpsyc.57.4.358

Cited by 569 publications

(431 citation statements)

References 27 publications

Supporting

Mentioning

366

Contrasting

Unclassified

Order By: Relevance

“…Twin studies suggest OCD is heritable, with concordance rates higher in monozygotic (80-87%) than dizygotic twins (47-50%) (Carey and Gottesman, 1981). Family studies find relatives of cases affected substantially more often than relatives of controls (Pauls et al, 1995;Nestadt et al, 2000). Obsessions and compulsions are remarkably diverse and are expressed with great variability across patients with OCD (Rasmussen and Eisen, 1988).…”

Section: Introductionmentioning

confidence: 99%

Further development of YBOCS dimensions in the OCD Collaborative Genetics Study: Symptoms vs. categories

Pinto

Greenberg

Grados

et al. 2008

Psychiatry Research

Self Cite

140

115

View full text Add to dashboard Cite

Despite progress in identifying homogeneous subphenotypes of obsessive compulsive disorder (OCD) through factor analysis of the Yale-Brown Obsessive Compulsive Scale Symptom Checklist (YBOCS-SC), prior solutions have been limited by a reliance on presupposed symptom categories rather than discrete symptoms. Furthermore, there have been only limited attempts to evaluate the © 2007 Elsevier Ireland Ltd. All rights reserved. *Corresponding author: Anthony Pinto, Ph.D., Butler Hospital, 345 Blackstone Blvd., Providence, RI 02906 USA; tel: 1-401-455-6299; fax: 1-401-455-6442; e-mail: Anthony_Pinto@brown.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript familiality of OCD symptom dimensions. The purpose of this study was to extend prior work by this collaborative group in category-based dimensions by conducting the first-ever exploratory dichotomous factor analysis using individual OCD symptoms, comparing these results to a refined category-level solution, and testing the familiality of derived factors. Participants were 485 adults in the six-site OCD Collaborative Genetics Study, diagnosed with lifetime OCD using semi-structured interviews. YBOCS-SC data were factor analyzed at both the individual item and symptom category levels. Factor score intraclass correlations were calculated using a subsample of 145 independent affected sib pairs. The item-and category-level factor analyses yielded nearly identical 5-factor solutions. While significant sib-sib associations were found for 4 of the 5 factors, Hoarding and Taboo Thoughts were the most robustly familial (r ICC ≥ 0.2). This report presents considerable converging evidence for a 5-factor structural model of OCD symptoms, including separate factor analyses employing individual symptoms and symptom categories, as well as sibling concordance.The results support investigation of this multidimensional model in OCD genetic linkage studies.

show abstract

Section: Introductionmentioning

confidence: 99%

Further development of YBOCS dimensions in the OCD Collaborative Genetics Study: Symptoms vs. categories

Pinto

Greenberg

Grados

et al. 2008

Psychiatry Research

Self Cite

140

115

View full text Add to dashboard Cite

show abstract

“…OCD is a common disorder, affecting between 2 and 3% of the population (Weissman et al, 1994). Although the precise etiology of the disorder remains unknown, the results of twin studies (Jonnal et al, 2000), family genetic studies (Nestadt et al, 2000b;Pauls et al, 1995), and segregation analyses (Alsobrook et al, 1999;Nestadt et al, 2000a) have provided compelling evidence that OCD has a strong genetic component. However, like other major psychiatric disorders, OCD fails to follow Mendelian patterns of inheritance and is considered as a complex genetic disorder.…”

Section: Introductionmentioning

confidence: 99%

Platelet Serotonergic Markers as Endophenotypes for Obsessive-Compulsive Disorder

Delorme

Betancur

Crinon

et al. 2005

Neuropsychopharmacol

View full text Add to dashboard Cite

Although compelling evidence has shown that obsessive-compulsive disorder (OCD) has a strong genetic component, its genetic basis remains to be elucidated. Identifying biological abnormalities in nonaffected relatives is one of the strategies advocated to isolate genetic vulnerability factors in complex disorders. Since peripheral serotonergic disturbances are frequently observed in OCD patients, the aim of this study was to investigate if they could represent endophenotypes, by searching for similar abnormalities in the unaffected parents of OCD patients. We assessed whole blood serotonin (5-HT) concentration, platelet 5-HT transporter (5-HTT) and 5-HT 2A receptorbinding characteristics, and platelet inositol trisphosphate (IP 3 ) content in a sample of OCD probands (n ¼ 48) and their unaffected parents (n ¼ 65), and compared them with sex-and age-matched controls (n ¼ 113). Lower whole blood 5-HT concentration, fewer platelet 5-HTT-binding sites, and higher platelet IP 3 content were found in OCD probands and their unaffected parents compared to controls. Whole blood 5-HT concentration showed a strong correlation within families (po0.001). The only parameter that appeared to discriminate affected and unaffected subjects was 5-HT 2A receptor-binding characteristics, with increased receptor number and affinity in parents and no change in OCD probands. The presence of peripheral serotonergic abnormalities in OCD patients and their unaffected parents supports a familial origin of these disturbances. These alterations may serve as endophenotypic markers in OCD, and could contribute to the study of the biological mechanisms and genetic underpinnings of the disorder.

show abstract

“…[1][2][3][4][5][6] Nevertheless, molecular genetic studies failed to individuate genes with minor or major effect in the susceptibility to OCD, 7,8 or reported contrasting results. [9][10][11][12] This could be due to the paucity of genes studied to date.…”

Section: Introductionmentioning

confidence: 99%

Obsessive-Compulsive Disorder, 5-HTTLPR polymorphism and treatment response

et al. 2002

View full text Add to dashboard Cite

Recently, a role for a functional polymorphism within the promoter region of the serotonin transporter gene (5-HTTLPR) in conferring susceptibility to Obsessive Compulsive Disorder (OCD) has been suggested. The aim of this study was to test the hypothesis that allelic variation of the 5-HTTLPR could be associated with OCD susceptibility or influence the drug response in OCD. One hundred and eighty-one OCD patients were recruited; 92 patients underwent a standardized treatment with fluvoxamine. No significant differences in allele/genotype distribution of the 5-HTTLPR were found between 191 controls and OCD. No differences in fluvoxamine response in the three genotypes groups in OCD were found, considering Yale-Brown Obsessive Compulsive Scale (YBOCS) total scores. Nevertheless, a significant time per genotype interaction was found for the YBOCS subtotal compulsion scores. Considering patients without tic disorder co-diagnosis, a significant time per genotype interaction for both YBOCS total scores and compulsion scores was found

show abstract

A Family Study of Obsessive-compulsive Disorder

Abstract: Obsessive-compulsive disorder is a familial disorder. Obsessions are more specific to the phenotype than are compulsions. Age at onset of OCD is valuable in characterizing a familial subtype.

Cited by 569 publications

References 27 publications

Further development of YBOCS dimensions in the OCD Collaborative Genetics Study: Symptoms vs. categories

Further development of YBOCS dimensions in the OCD Collaborative Genetics Study: Symptoms vs. categories

Platelet Serotonergic Markers as Endophenotypes for Obsessive-Compulsive Disorder

Obsessive-Compulsive Disorder, 5-HTTLPR polymorphism and treatment response

Contact Info

Product

Resources

About