A family history of diabetes determines poorer glycaemic control and younger age of diabetes onset in immigrants from the Middle East compared with native Swedes

Bennet, Louise; Lindblad, Ulf; Franks, Paul W.

doi:10.1016/j.diabet.2014.08.003

Cited by 16 publications

(12 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We have concluded that the lower disposition index in the non-diabetic immigrant population can contribute to their higher HbA1c levels and earlier diabetes onset [9]. Here we show that BMI and waist circumference levels for the corresponding levels of disposition index are even lower than for the corresponding levels of insulin resistance reflecting that we do not overestimate the impact of BMI and waist circumference on diabetes risk in the Iraqi born population.…”

Section: Discussionmentioning

confidence: 46%

“…Dysfunctional insulin sensitivity, or insulin resistance, is dependent on ectopic fat accumulation in liver, visceral adipose tissue, and skeletal muscle [8]. Although the Iraqi immigrant population is generally more obese (BMI > 30 kg/m 2 ) than the native Swedish population (37.5% vs 23.0%, p < 0.001) [9], the reduced insulin sensitivity in this population is not fully explained by BMI or other cardiometabolic risk factors [7]. These findings are consistent with other studies reporting different fat distributions across ethnicities and consequently highlight the limitation of BMI as a measure of adiposity [10].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

BMI and waist circumference cut-offs for corresponding levels of insulin sensitivity in a Middle Eastern immigrant versus a native Swedish population – the MEDIM population based study

et al. 2016

View full text Add to dashboard Cite

BackgroundThe aim of this study was to identify corresponding body mass index (BMI) and waist circumference cut-offs for equivalent levels of insulin sensitivity in a Middle Eastern immigrant population compared with native Swedes.MethodsCitizens of Malmö, Sweden aged 30 to 75 years, who were born in Iraq or Sweden, were in 2010–2012 invited to participate in a health examination including anthropometrics, oral glucose tolerance test, fasting samples and interviews concerning sociodemographic factors and lifestyle behaviours.ResultsIn total, 1176 individuals born in Iraq and 688 born in Sweden, without previously diagnosed type 2 diabetes, participated in the study. In normal weight participants (BMI < 25 kg/m2), 21.2% of Iraqis vs 9.3% of Swedes were insulin resistant. Corresponding figures in participants without abdominal obesity (waist circumference, men < 94 cm, women < 80 cm) were 28.2% of Iraqis vs 9.4% of Swedes.The age-adjusted insulin sensitivity index (ISI) for obese Swedes (BMI 30 kg/m2) corresponded in Iraqi men with BMI of 28.5 kg/m2, and in Iraqi women with BMI of 27.5 kg/m2. The ISI level in abdominally obese Swedes corresponded with waist circumference cut-offs of 84.0 cm and 71.0 cm in Iraqi men and women, respectively.In men only, larger waist circumference (P interaction = 0.026) presented a stronger association with impaired ISI in Iraqis as compared to Swedes.ConclusionsOur data shows that the impact of BMI and waist circumference on ISI is ethnic- and gender-specific, indicating a disturbed fat metabolism in Iraqi males in particular. Our data suggests that 10 cm lower cut-off values for abdominal obesity, than is currently recommended by major organisations, should be considered when estimating diabetes risk in Middle Eastern populations.Electronic supplementary materialThe online version of this article (doi:10.1186/s12889-016-3892-1) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 46%

Section: Introductionmentioning

confidence: 99%

BMI and waist circumference cut-offs for corresponding levels of insulin sensitivity in a Middle Eastern immigrant versus a native Swedish population – the MEDIM population based study

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Nordic studies of immigrants from countries where Kurds originate have examined the prevalence of T2DM or risk factors for the disease [14,15,[56][57][58][59][60][61]. A 2013 Swedish study confirmed, as expected, that the prevalence of T2DM was higher among Iraqi immigrants than Swedish participants (8.4% vs. 3.3%) [61].…”

Section: The T2dm Situation In Norwaymentioning

confidence: 79%

Living with Diabetes: Personal Interviews with Pakistani Women in Norway

Abuelmagd

Håkonsen

Mahmood

et al. 2017

J Immigrant Minority Health

View full text Add to dashboard Cite

The prevalence of Type 2 diabetes (T2D) among Pakistani women in Norway is remarkably high. This study aims to assess how they live with the disease and their response to lifestyle and medical information. 120 Pakistani women living in Norway (mean age: 55.7 years) were personally interviewed about their T2D using a structured questionnaire (response rate: 95%). The participants were first-generation immigrants (mean residence time: 28.7 years) of whom 27% were illiterates. Poor health was reported by one-third, and 71% had developed macrovascular comorbidities. A majority reported physical inactivity and an unhealthy diet included religious fasting. One-third was not able to self-measure their blood glucose. There was a great variation in antidiabetic drug regimens and one-fourth had to use insulin in addition to tablets. Pakistani women in Norway showed suboptimal control of their T2D in terms of lifestyle habits, comorbidities and drug use. Low literacy and cultural factors seem to challenge adherence to lifestyle and medical information.

show abstract

“…Our data further suggests that the Iraqi population with NAFLD is younger than the Swedish born population. This may reflect an earlier onset of disturbed fat metabolism contributing to insulin resistance and an earlier diabetes onset in Iraqi immigrants that we have previously reported [28]. Increased knowledge of the mechanisms triggering insulin action in different populations is important for better understanding in this high risk population for type 2 diabetes.…”

Section: Nafld and Ethnic Differencesmentioning

confidence: 60%

Country of birth modifies the association of fatty liver index with insulin action in Middle Eastern immigrants to Sweden

Bennet

Groop

Franks

2015

Diabetes Research and Clinical Practice

View full text Add to dashboard Cite

show abstract

A family history of diabetes determines poorer glycaemic control and younger age of diabetes onset in immigrants from the Middle East compared with native Swedes

Abstract: The study shows that the greater predisposition to diabetes in Middle Eastern immigrants may be explained by a more extensive family history of the disorder; clinical interventions tailored to Middle Eastern immigrants with such a family history are thus warranted.

Cited by 16 publications

References 29 publications

BMI and waist circumference cut-offs for corresponding levels of insulin sensitivity in a Middle Eastern immigrant versus a native Swedish population – the MEDIM population based study

BMI and waist circumference cut-offs for corresponding levels of insulin sensitivity in a Middle Eastern immigrant versus a native Swedish population – the MEDIM population based study

Living with Diabetes: Personal Interviews with Pakistani Women in Norway

Country of birth modifies the association of fatty liver index with insulin action in Middle Eastern immigrants to Sweden

Contact Info

Product

Resources

About