A family-based association study of PLP1 and schizophrenia

The myelin-pathogenesis puzzle in schizophrenia: a literature review

“…Further evidence for the downregulation of PLP1 in schizophrenic individuals comes from a family-based association study in 487 Chinese Han family trios. 125 Myelin oligodendrocyte glycoprotein (MOG), which is both a target antigen for myelin-destructive antibodies in autoimmune CNS demyelization disorders and a cellsurface marker for oligodendrocyte maturation, was also shown to be downregulated in the study by Tkachev et al 118 and in Han Chinese samples. 126 However, no evidence for association with schizophrenia was reported for MOG in Caucasian samples.…”

No association between the oligodendrocyte-related gene PLP1 and schizophrenia in the Japanese population

“…In other words, regarding our sample, to detect association when minor allele frequency was set to population-based data (rs475827), in order to achieve 80% of power, GRR has to be more than 1.8 (for gender-stratified data). On the other hand, regarding the schizophrenia-associated SNP rs475827, sample (N male trios = 253) in the original report (Qin et al 2005), the same minor allele frequency and GRR had only 51% of power for detecting association.…”

“…However, our study, based on adequate statistical power, did not support association between schizophrenia and the PLP1 locus. As lack of replication may also be falsely negative, possibly due to the lack of adequately powered sample sizes, we performed a power analysis of the sample from the initial report (Qin et al 2005). This analysis showed that the sample used in our research had a higher level of power.…”

“…Based on the aforementioned criteria, three SNPs (rs471416, rs2233696, and rs10521502) were selected for genotyping. The SNP from the initial report (Qin et al 2005) that had been shown to be associated with schizophrenia (rs475827) failed to met tagging SNP criteria due to low minor allele frequency in the Japanese population (4.7%). However this SNP was included as well, as it is the SNP that was shown to be associated with schizophrenia.…”

“…One study examined the hypothesis of PLP1 as candidate gene (Qin et al 2005), and data provided evidence for genetic association with schizophrenia. As PLP1 is indeed an attractive candidate gene for schizophrenia, we performed a gene-centric (Neale and Sham 2004) association study using a large Japanese sample to replicate previous findings.…”