A Falling‐Film Microreactor for Enzymatic Oxidation of Glucose

Abstract

Nothing ROMP with that: Unsymmetrical double‐stranded ladderphanes are obtained by sequential ring‐opening metathesis polymerization and Glaser oxidation of norbornene appended with bisalkyne moieties. Hydrolysis of these ladderphanes gives substituted poly(m‐phenylene butadiynylene)s with narrow polymer dispersity index (PDI) and well‐controlled degree of polymerization.

Liquid phase oxidation chemistry in continuous-flow microreactors

“…222 FFMR utilizes gravity to establish a thin liquid film which is brough inot contact with the gas phase. The FFMR ensures permanent oxygen saturation, even at high reaction rates.…”

“…Aerobic oxidation of ß-D-glucose catalyzed by glucose oxidase in a FFMR. 222 With the use of a sequential tube-in-tube reactor setup, Buehler et al were able to produce 3-phenylcatechol on a preparative scale (1 gram) with a STY of 14.5 g.L -1 .h -1 (Scheme 22). 224 Heterogeneous catalysis.…”

Catalytic Transformation of Biomass Derivatives to Value‐Added Chemicals and Fuels in Continuous Flow Microreactors

“…Due to the strong shear force generated by centrifugal forces in the CCCS, liquid-liquid mixing is enhanced considerably, accelerating reactions with fast kinetics that are limited by mass transfer. [134] Typically, microreactors have been used for single liquid phase and biphasic (gas-liquid or liquid-liquid) catalytic transformation of biomass derivatives to valuable products using homogeneous or heterogeneous catalysts (e. g., the (biphasic) synthesis of furans from sugars, [135][136][137][138][139][140][141][142][143][144] (aerobic) oxidation, [144][145][146][147][148][149] and hydrogenation of biomass derivatives [144,[150][151][152][153] ). [126] Another intensified reactor configuration for multiphase (gasliquid or liquid-liquid) catalytic biomass transformation is the spinning disc reactor, consisting of a rotating disc around which fluids are fed.…”

“…[265,266] Microreactors have potential for the aerobic oxidation of glucose as it can significantly increase the reaction rate by the enhancement of oxygen supply. [145] In this reactor system, the reaction took place along three vertical reaction plates (consisting of 16 channels, width × height (W × H) = 1200 × 400 μm; 32 channels, 600 × 200 μm; 64 channels, 300 × 100 μm). The reaction was performed in a falling film microreactor using glucose oxidase as a homogeneous enzymatic catalyst dissolved in the aqueous phase ( Table 5, entry 1).…”

“…So far, oxidation of glucose to gluconic acid, HMF to DFF, FFCA and FDCA, lactates to pyruvates and lignin to vanillin have been shown intensified by the enhanced and more controlled heat/ mass transfer during flow operation in microreactors, particularly in multiphase gas-liquid flow or in a permeable tube-intube microreactor configuration (Table 5). [144][145][146][147]149] The benefits of performing (aerobic) oxidation reactions in microreactors (of non-biomass derivatives) has been reviewed by multiple groups. [262][263][264] Heterogeneously catalyzed oxidation reactions have been shown to benefit from microreactor operation as compared to larger scale flow reactors.…”